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Riboflavin operon of Bacillus subtilis: unusual symmetric arrangement of the regulatory region

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Summary

Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were localized to the region between nucleotides + 37 and + 159 relative to the transcription initiation site of the riboflavin operon. This region displays an unusual structure for regulatory sequences. The main part of it represents clusters of A/T and G/Grich sequences that symmetrically blank a short inverted repeat.

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Authors and Affiliations

  1. Department of Molecular and Radiation Biophysics, Leningrad Nuclear Physics Institute of the Academy of Sciences of the USSR, 188350, Gatchina, Leningrad District, USSR

    Yuri V. Kil, Vladimir N. Mironovi, Igor Yu. Gorishin, Rimma A. Kreneva & Daniel A. Perumov

  2. Centre of Bioengineering, Institute of Molecular Biology of the Academy of Sciences of the USSR, 117984, Moscow, USSR

    Vladimir N. Mironovi

Authors
  1. Yuri V. Kil
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  2. Vladimir N. Mironovi
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  3. Igor Yu. Gorishin
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  4. Rimma A. Kreneva
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  5. Daniel A. Perumov
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Communicated by H. Hennecke

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Kil, Y.V., Mironovi, V.N., Gorishin, I.Y. et al. Riboflavin operon of Bacillus subtilis: unusual symmetric arrangement of the regulatory region. Molec. Gen. Genet. 233, 483–486 (1992). https://doi.org/10.1007/BF00265448

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