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Quality control of colloid and particulate 99mTc-labeled radiopharmaceuticals

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Abstract

A procedure for the radiochemical purity control of colloid and particulate 99mTc-labeled radiopharmaceuticals is described. The proposed technique is based on the use of two chromatograms, using in both, 15% H3PO4 as solvent and impregnated glass fiber media (Gelman ITLC type SG) as stationary phase. A pretreatment of the radiopharmaceutical with 6 N NaOH is involved prior to one chromatographic run. The procedure is fast and the different species (free pertechnetate, 99mTc-Sn-colloid and labeled 99mTc) in a 99mTc-labeled radiopharmaceutical can be determined accurately and with reliability.

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Authors and Affiliations

  1. Isotopes Division, Nuclear Research Center “Demokritos”, Athens, Greece

    Elias P. Belkas & Spyridon Archimandritis

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  1. Elias P. Belkas
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  2. Spyridon Archimandritis
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Belkas, E.P., Archimandritis, S. Quality control of colloid and particulate 99mTc-labeled radiopharmaceuticals. Eur J Nucl Med 4, 375–377 (1979). https://doi.org/10.1007/BF00263307

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  • DOI: https://doi.org/10.1007/BF00263307

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