Skip to main content
SpringerLink
Log in

A phase II study of vincristine in malignant mesothelioma — a negative report

  • Short Communication
  • Vincristine, Malignant Mesothelioma
  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

A total of 23 consecutive, previously untreated patients with radiographically evaluable, malignant pleural mesothelioma were treated in a phase II study with vincristine. Vincristine was given i.v. at a dose of 1.3 mg/m2 once weekly for 4 weeks, then every 2 weeks. No response was observed. The result suggests that vincristine has little or no therapeutic value in the treatment of malignant mesothelioma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Butchart EG, Ashcroft T, Barnsley WC, Holden MP (1976) Pleuro-pneumonectomy in the management of diffuse malignant mesothelioma of the pleura. Thorax 31: 15–24

    Google Scholar 

  2. Cantwell BMJ, Franks CR, Harris AL (1986) A phase II study of the platinum analogues JM8 and JM9 in malignant pleural mesothelioma. Cancer Chemother Pharmacol 18: 286–288

    Google Scholar 

  3. Chahinian AP, Holland JF (1978) Treatment of diffuse malignant mesothelioma: a review. M Sinai J Med 45: 45–67

    Google Scholar 

  4. Gordon W, Antman KH, Greenberger (1982) Radiation therapy in the management of patients with mesothelioma. Int J Radiat Oncol Biol Phys 8: 19–25

    Google Scholar 

  5. Gottlieb JA, Bodey GP, Sinkovics JG (1975) An effective new four drug combination regimen (CY-VA-DIC) for metastatic sarcomas. Am Assoc Cancer Res/Am Soc Clin Oncol 15: 162

    Google Scholar 

  6. Karakousis CP, Seddiq M, Moore R (1980) Malignant mesotheliom and chemotherapy. J Surg Oncol 15: 181–185

    Google Scholar 

  7. Larsson S, Philipson BM, Dernevik L, Zettergren L (1988) Clinicopathological studies on mesothelioma of the pleura: different approach to treatment. Scand J Thorac Cardiovasc Surg 22: 65–72

    Google Scholar 

  8. Law MR, Gregor A, Hodson M (1984) Malignant mesothelioma of the pleura: a study of 52-treated and 64 untreated patients. Thorax 39: 255–259

    Google Scholar 

  9. Lerner HJ, Schoenfeld DA, Martin A (1983) Malignant mesothelioma: the Eastern Cooperative Oncology Group (ECOG) experience. Cancer 52: 1981–1985

    Google Scholar 

  10. Mårtensson G, Hagmar B, Zettergren L (1984) Diagnosis and prognosis in malignant pleural mesothelioma: a prospective study. Eur J Respir Dis 65: 169–178

    Google Scholar 

  11. Mbidde EK, Harland SJ, Calvert AH, Smith IE (1986) Phase II trial of carboplatin (JM8) in treatment of patients with malignant mesothelioma. Cancer Chemother Pharmacol 18: 284–285

    Google Scholar 

  12. Sørensen PG, Bach F, Bork E, Hansen HH (1985) Randomized trial of doxorubicin versus cyclophosphamide in diffuse malignant pleural mesothelioma. Cancer Treat Rep 69 (12): 1431–1432

    Google Scholar 

  13. Solheim O (1987) High-dose methotrexate in the treatment of malignant mesothelioma of the pleura: a preliminary report. 15th International Congress of Chemotherapy, Istanbul, Turkey,

  14. Voss AC, Vollgens P, Untucht HJ (1974) Das Pleuramesotheliom aus strahlentherapeutischer Sicht. Strahlentherapie 148: 328–332

    Google Scholar 

  15. World Health Organisation (1979) WHO handbook for reporting results of cancer treatment. Offset publication 48. WHO, Geneva

    Google Scholar 

  16. World Health Organsisation (1981) Histological typing of lung tumours, 2nd edn. In: International histological classification of tumours I. WHO, Geneva

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pulmonary Medicine, Renströmska Hospital, University of Göteborg, Göteborg, Sweden

    Gunnar Mårtensson & Sverre Sörenson

Authors
  1. Gunnar Mårtensson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sverre Sörenson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mårtensson, G., Sörenson, S. A phase II study of vincristine in malignant mesothelioma — a negative report. Cancer Chemother. Pharmacol. 24, 133–134 (1989). https://doi.org/10.1007/BF00263135

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00263135

Keywords

Search

Navigation