Abstract
A six-compartment model is proposed for the study of early iodine kinetics (150 min) in the human thyroid gland including three compartments for extrathyroidal spaces. The results were compared with those obtained with an open two-compartment thyroidal model.
In six euthyroid subjects the values of the unidirectional thyroid clearance R41=86±25 ml/min and of the irreversible clearance R65=22±9 ml/min were consistent with those generally accepted. With TSH stimulation a clear increase in the thyroidal pump effectiveness was found without an increase in the irreversible clearance.
In four untreated thyrotoxic patients a tenfold increase in the unidirectional thyroid clearance was found (P<0.01). The binding rate was much less increased and overlapped with the normal values; a large increase in the iodide compartment volumes was found. The unidirectional clearance remained elevated in seven patients after Carbimazole treatment and the binding rates were reduced. The six-compartment model demonstrated a rapid exit from the bound iodine compartment.
In three of four goitrous patients studied, the thyroid unidirectional clearance was significantly increased (P<0.001). The volumes of the iodide compartments were much higher than those observed in the other groups.
The method was applied to analyse the kinetics of different parts of the thyroid.
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References
Akerman M, Di Paola R, Tubiana M (1967) Estimation of the absolute thyroid uptake of stable 127I using a simplified method and comparison of the results with two classic methods. J Clin Endocrinol Metab 27:1309–1320
Alexander WD, Shimmins J, Robertson JWK, Horton PW, McLarty DG, Harden RMcG (1971) Radioisotope studies of thyroid function and thyroid hormone metabolism. In: Dynamic studies with radioisotopes in clinical medicine and research. IAEA Vienna, pp 179–190
Bazin JP, Marchadier B, Lafuma J (1971) Traitement mathématique de données métaboliques liées à la théorie des compartiments. In: Premier Congrès Européen de Radioprotection, Menton 1968, CEA Saclay, pp 374–380
Belshaw BE, Barandes M, Becker DV, Berman M (1974) A model of iodine kinetics in the dog. Endocrinology 95:1078–1093
Berman M, Hoff E, Barandes M, Becker DV, Sonenberg M, Benua R, Koutras DA (1968) Iodine kinetics in man — A model. J Clin Endocrinol Metab 28:1–14
Decostre Ph, Brooke Ph, Dobbeleir A, Erbsmann F (1976) Earlythyroidal iodide and pertechnetate kinetics: New approach with a scintillation camera and a computer. In: Robbins J, Braverman LE (eds) Thyroid research. Amsterdam and New York, Excerpta Med and Amer Elsevier Publ co, pp 590–593
De Crombrugghe B, Beckers C, De Visscher M (1964) Bilan du cycle de l'iode chez des sujets euthyroidiens non goîtreux. Rev Franç Etudes Clin et Biol 9:307–313
Demeester-Mirkine N, Van Sande J, Corvilain J, Dumont JE (1975) Benign thyroid nodule with normal iodide trap and defective organification. J Clin Endocrinol Metab 41:1169–1171
Di Paola R, Bazin JP, Di Paola M (1973) Improvement of gamma camera data processing due to sequential acquisition. In: Metz CE, Pizer SM, Brownell GL (eds) Information processing in scintigraphy. USERDA Technical Information Center, Oak Ridge, pp 115–124
Dumont JE (1971) The action of thyrotropin on thyroid metabolism. Vitam Horm 29:287–412
Ermans AM, Dumont JE, Bastenie PA (1963) Thyroid function in a goitrous endemic: II nonhormonal iodine escape from the goitrous gland. J Clin Endocrinol Metab 23:550–560
Field JB, Larsen PR, Yamashita K, Mashiter K, Dekker A (1973) Demonstration of iodide transport defect but normal iodide organification in non functioning nodules of human thyroid glands. J Clin Invest 52:2404–2410
Fisher DA, Oddie TH, Thompson CS (1971) Thyroidal thyronine and non-thyronine iodine secretion in euthyroid subjects. J Clin Endocrinol Metab 33:647–652
Fragu P, Regard E, Ben Othman S, Beaumont A, Nataf BM (1977) Correlation of thyroid peroxidase activity and its localization in sporadic goiter and in a case of congenital goiter. 8th Meeting of European Thyroid Association (ETA), Lyon 1977. Ann Endocr (Paris) 38:142 (abstract)
Hays MT (1978) Kinetics of the human thyroid trap: A compartmental Model: J Nucl Med 19:789–795
Hays MT (1979a) Kinetics of the human thyroid trap: Experience in normal subjects and in thyroid disease. J Nucl Med 20:219–223
Hays MT (1979b) Kinetics of the human thyroid trap: Effects of iodide, thyrotropin and propylthirouracil. J Nucl Med 20:944–949
Ingbar SH (1972) Autoregulation of the thyroid. Response to iodide excess and depletion. In: Second F, Raymond Keating JR (eds) Memorial Symposium Mayo Clinic Proceedings, pp. 814–823
Olsson DM (1974) A sequential simplex program for solving minimization problems. J Quality Technol 6:53–57
Robertson JWK, Lazarus JH, Shimmins J, Alexander WD, Horton PW (1971) Determination of the rates of accumulation and loss of iodide and of protein binding of iodine in the human thyroid gland. In Dynamic studies with radioisotopes in clinical medicine and research, pp 199–209, Vienna, IAEA
Savoie JC, Vallee G, Massin JP (1970) Cinetique de l'iodure chez l'homme. Analyse par ordinateur et modèle tricompartimental. I. Application à l'athyroïdie et au goître simple. Ann Endocr (Paris) 31:688–698
Simmins J, Hilditch J, Harden RMcG, Alexander WD (1968) Thyroidal uptake and turnover of the pertechnetate ion in normal and hyperthyroid subjects: J Clin Endocr Metab 28:575–581
Slingerland DW, Burrows BA (1962) A probable abnormality in intrathyroidal iodine metabolism in hyperthyroidism. J Clin Endocr Metab 22:368–376
Taurog A (1976) The mechanism of action of the thioureylene antithyroid drugs. Endocrinology 98:1031–1046
Thomas-Morvan C, Nataf BM, Tubiana M (1973) Thyroid proteins and hormone synthesis in various benign thyroid diseases: in vivo and organ culture studies. Acta Endocr. (KBH) 73:22–34
Thomas-Morvan C, Nataf BM, Tubiana M (1974) Thyroid proteins and hormone synthesis in human thyroid cancer. Acta Endocr (KBH) 76:651–669
Tubiana M, Fragu P, de Tovar G, Bazin JP (1971) The radioactive iodine uptake and the absolute iodine uptake in euthyroid subjects with and without sporadic goiter. Rev Europ Etudes Clin Biol 16:250–255
Tubiana M, Morvan C, Nataf BM (1973) Concentration intrathyroïdienne de l'iode et hormongénèse dans divers types d'affection thyroïdienne. Ann Endocr (Paris) 34:563–577
Vignal A, Nataf BM, Tubiana M (1978) Iodoamino-acid composition of poorly iodinated human thyroglobulin fractionated by isopycnic centrifugation. Acta Endocr (KBH) 87:320–329
Wollmann SH, Reed FE (1959) Transport of radioiodide between thyroid gland and blood in mice and rats. Am J Physiol 196:113–120
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Research supported by DGRST (Contract 7371600) and INSERM (CRL 7750943 B)
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Bazin, J.P., Fragu, P., Di Paola, R. et al. Early kinetics of thyroid trap in normal human patients and in thyroid diseases. Eur J Nucl Med 6, 317–326 (1981). https://doi.org/10.1007/BF00262526
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DOI: https://doi.org/10.1007/BF00262526