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The use of sodium bicarbonate in the therapy of organic acidosis

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References

  1. Ostrea EM, Odell GF (1972) The influence of bicarbonate administration on blood pH in a “closed system”: clinical implications. Fetal Neonat Med 80:671

    Google Scholar 

  2. Assal J, Aoki TT, Manzano FM, Kozak GP (1974) Metabolic effects of sodium bicarbonate in management of diabetic ketoacidosis. Diabetes 23:405

    Google Scholar 

  3. Ohmann JL, Marlis EB, Aoki TT, Munichoodappa CS, Khanna VV, Kozak GP (1971) The cerebrospinal fluid in diabetic ketoacidosis. N Engl J Med 284:283

    Google Scholar 

  4. Posner JB, Plum F (1967) Spinal-fluid pH and neurologic symptoms in systemic acidosis. N Engl J Med 277:605

    Google Scholar 

  5. Lever E, Jaspan JB (1983) Sodium bicarbonate therapy in severe diabetic ketoacidosis. Am J Med 75:263

    Google Scholar 

  6. Bureau MA, Begin R, Berthiaune Y, Shappcott D, Khoury K, Gagnonn N (1980) Cerebral hypoxia from bicarbonate infusion in diabetic acidosis. J Pediatr 96:968

    Google Scholar 

  7. Bishop RL, Weisfeldt ML (1976) Sodium bicarbonate administration during cardiac arrest. Effect on arterial pH, pCO2, and osmolality. JAMA 235:506

    Google Scholar 

  8. Mattar JA, Weil MH, Shubin H, Stein L (1974) Cardiac arrest in the critically ill. II: hyperosmolal states following cardiac arrest. Am J Med 56:162

    Google Scholar 

  9. Ng ML, Levy MN, Zieske HA (1967) Effects of changes of pH and of carbon dioxide tension on left ventricular performance. Am J Physiol 213:115

    Google Scholar 

  10. Downing SE, Talner NS, Gardner TH (1965) Cardiovascular responses to metabolic acidosis. Am J Physiol 208:H237

    Google Scholar 

  11. Downing SE, Lee JC, Werner JC (1981) Effects of insulin on ventricular function in diabetic lambs with acidosis. Am J Physiol 241:H401

    Google Scholar 

  12. Steenbergen C, Deleuw G, Rich T, Williamson JR (1977) Effects of acidosis and ischemia on contractility and intracellular pH of rat heart. Circ Res 41:849

    Google Scholar 

  13. Arieff AI, Gertz EW, Park R, Leach W, Lazarowitz VC (1983) Lactic acidosis and the cardiovascular system in the dog. Clin Sci (Oxford) 64:573

    Google Scholar 

  14. Graf H, Leach W, Arieff AI (1985) Evidence for a detrimental effect of bicarbonate therapy in hypoxic lactic acidosis. Science 227:754

    Google Scholar 

  15. Waters WC, Hall JD, Schwartz WB (1963) Spontaneous lactic acidosis. Am J Med 35:781

    Google Scholar 

  16. Narins RG, Jones ER Townsend R, Goodkin DA, Shay RJ (1985) Metabolic acid base disorders; pathophysiology, classification and treatment. In: Arieff AI, DeFronzo RA (eds) Fluid, electrolyte and acid base disorders. Churchill Livingstone, New York, pp 281–335

    Google Scholar 

  17. Park R, Arieff AI (1983) Pathogenesis and treatment of lactic acidosis. In: Clinics in endocrinology and metabolism 12:339; WB Saunders, Philadelphia

    Google Scholar 

  18. Minot AS, Dodd K, Saunders JM (1934) The acidosis of guanidine intoxication. J Clin Invest 13:917

    Google Scholar 

  19. Arieff AI, Park R, Leach W, Lazarowitz VC (1982) Systemic effects of NaHCO3 in experimental lactic acidosis in dogs. Am J Physiol 242:F586

    Google Scholar 

  20. Graf H, Leach W, Arieff AI (1986) Metabolic effects of sodium bicarbonate in hypoxic lactic acidosis in dogs. Am J Physiol (in press)

  21. Stacpoole PW, Harmen EW, Curry SH, Baumgartner TG, Misbin RI (1983) Treatment of lactic acidosis with dichloroacetate. N Engl J Med 309:390

    Google Scholar 

  22. Graf H, Leach W, Arieff AI (1985) Effects of dichloroacetate in the treatment of hypoxic lactic acidosis in dogs. J Clin Invest 76:919

    Google Scholar 

  23. Bersin R, Chatterjee K, Arieff AI (1986) Metabolic and systemic effects of bicarbonate in hypoxic patients with heart failure. Kidney Int 29

  24. Arieff AI, Park R, Leach W, Lazarowitz VC (1980) Pathophysiology of experimental lactic acidosis in dogs. Am J Physiol 239:F135

    Google Scholar 

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Author notes

  1. H. Graf

    Present address: Department of Internal Medicine, University of Vienna, Austria

Authors and Affiliations

  1. Nephrology Research, Veterans Administration Medical Center, San Francisco, California, USA

    H. Graf & A. I. Arieff

  2. University of California, San Francisco, California, USA

    H. Graf & A. I. Arieff

Authors
  1. H. Graf
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  2. A. I. Arieff
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Graf, H., Arieff, A.I. The use of sodium bicarbonate in the therapy of organic acidosis. Intensive Care Med 12, 285–288 (1986). https://doi.org/10.1007/BF00261737

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  • DOI: https://doi.org/10.1007/BF00261737

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