Summary
Urine cytology was evaluated in 8,406 male workers of 8 petrochemical factories in western and northern Germany during the routine medical check-up performed by the department of industrial medicine of the respective factory. All relevant data referring to possible private and occupational risk factors were registered and evaluated. Four percent (n=358) of the 8,406 workers examined exhibited Pap 3/4 cytology. Urological examination did not reveal any bladder tumor in those workers with either a single Pap 4 or a repeated Pap 3 finding on cytology. Our study showed that deterioration of cell differentiation correlated significantly with age and cigarette smoking. Furthermore, a risk group (males above 40 years of age exposed to occupational chemicals, smokers, and coffee drinkers) differed from a non-risk group. Age and cigarette smoking seemed to be the determinant factors. No correlation could be adduced between any kind of industrial exposure and urine cytology.
Similar content being viewed by others
References
Adolphs H-D, Thiele J, Vahlensieck W (1980) Epidemiologie und Pathogenese der Harnblasenkarzinome. Onkologie 5:214
Berndt H, Berndt R (1982) Inzidenz und Mortalität an bösartigen Neubildungen der Harnorgane und der männlichen Geschlechtsorgane in der DDR. Urologe (A) 21:185
Cartwright RA, Adib R, Glashan R, Gray BK (1981) The epidemiology of bladder cancer in West Yorkshire. A preliminary report on nonoccupational aetiologies. Carcinogenesis 2:343
Case RAM, Hosker ME, McDonald DB, Pearson JT (1954) Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the british chemical industry. Br J Industr Med 11:75
Clemmesen J, Nielsen A (1956) Cancer incidence in Denmark 1943 to 1953. II. Tumors of the urinary system and prostate. Dan Med Bull 3:36
Cohen SM, Wittenberg JF, Bryan GT (1976) Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide. Cancer Res 36:2334
Cohen SM, Arai M, Jacobs JB, Friedell GH (1979) Promoting effect of saccharin and DL-Tryptophan in urinary bladder carcinogenesis. Cancer Res 39:1207
Cole P, Monson RR, Haning H, Friedel GH (1971) Smoking and cancer of the lower urinary tract. N Engl J Med 284:129
Cole P (1973) Population based study of bladder cancer. In: Doll R, Vodopija I (eds) Host environment interactions in the etiology of cancer in man. 83. Lyon, France: International Agency for Research on Cancer
Coon JS, Pauli BU, Weinstein RS (1983) Precancer of the urinary bladder. Cancer Surveys 2:479
Davies JM, Sommerville M, Wallace DM (1976) Occupational bladder tumor cases identified during ten years interviewing of patients. Br J Urol 48:561
El-Bokainy MN (1980) Cytology of bladder carcinoma. J Urol 124:20
Glashan RW, Wijesinghe DP, Riley A (1981) The early changes in the development of bladder cancer in patients exposed to know industrial carcinogens. Br J Urol 53:571
Glashan RW, Cartwright RA (1981) Occupational bladder cancer and cigarette smoking in West Yorshire. Br J Urol 53:602
Goerttler K, Loehrke H, Schweizer J, Hesse B (1979) Systemic twostage carcinogenesis in the epithelium of the forestomach of mice using 7,12-dimentylbenz (a) anthracence as initiator and the phorbolester 12-0-tetradecanoyl-phorbol-13-acetate as promoter. Cancer Res 39:1293
Hammond EC, Horn D (1958) Smoking and death rates. Report on forty-four months of follow-up of 187,183 men. II. Death rates by cause. J Am Med Ass 166:1294
Hartege P, Hoover R, West DW, Lyon JL (1983) Coffee drinking and the risk of bladder cancer. J Natl Cancer Inst 70:1021
Hicks RM, Wakefield JSt, Chowaniec J (1975) Evaluation of a new model to detect bladder carcinogens of co-carcinogens; results obtained with saccharin, cyclamate and cyclophosamide. Chem Biol Interact 11:225
Hicks RM (1980) Multistage carcinogenesis in the rat urinary bladder-further investigation of the promotion phase. Tox Res Proj Direc 5:8801
Hoffmann D, Wynder EL (1976) Smoking and occupational cancers. Prev Med 5:245
Inoue T, Yoshimoto T, Ogura T, Hirao F (1981) Effect of nocardia rubra cell-wall skeleton treatment on tumor in two-stage chemical carcinogenesis of mouse skin. Cancer Immun 11:207
Kahn HA (1966) The Dorn study of smoking and mortality among United Staates veterans. Report on 8 1/2 years of observation. In: Epidemiological approaches to the study of cancer and other chronic diseases. Nat Cancer Inst Monogr 19:1 (Government Printing Office, Washington DC)
Kakizoe T, Esumi H, Kawachi T, Sugimura T, Takeuchi T, Umezawa H (1977) Further studies on the effect of leupeptin, a protease inhibitor, on induction of bladder tumors in rats by N-Butyl-N-(4-hydroxybutyl) nitrosamine. J Nat Cancer Inst 59:1503
Lopez-Abente G (1983) Bladder cancer in spain. Cancer 51:2367
Lower GM (1982) Concepts in causality: chemically induced human urinary bladder cancer. Cancer 49:1056
Matsushima M (1977) The role of L-tryptophan's promoting factor on tumorgenesis in the urinary bladder. II: Urinary bladder carcinogenicity of FANFT (initiating factor) and L-tryptophan (promoting factor) in mice. Nippon Hinyokika Gakkai Zasshi 68:731
Miyata Y, Bagaya K, Oyasu R (1981) Carcinogenesis in heterotopically-transplanted urinary bladder N-methyl-N-nitrosourea: a model for initiation and promotion. Carcinogeneses 2:495
Morrison AS, Cole P (1976) Epidemiology of bladder cancer. Urol Clin North Am 3:13
Morrison AS (1978) Cancer of the urinary bladder, epidemiology and aetiology. Urol Res 6:183
Muir CS, Wagner G (1980) Directory of on-going researchs in cancer epidemiology 1980. IARC (International agency for research on cancer), Lyon
Najem GR, Louria DB, Seebode JJ, Thind IS, Prusakowski JM, Ambrose RB, Fernicola AR (1985) Life time occupation, smoking, caffeine, saccharine, hair dey and bladder carcinogenesis. J Urol (in press)
Nakanishi K, Hirose M, Ogiso T, Hasegawa R, Arai MM, Ito N (1980) Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with n-butyl-n-(4-hydroxybutyl) nitrosamine. Gann 71:490
Okajima E, Hiramatsu T, Motomiya Y, Kondo T, Hirao J (1973) Effects of foreign bodies on development of urinary bladder tumors in tats treated with n-tutyl-n-(3-hydroxybutyl) nitrosamine. Urol Res 1:77
Oyasu R, Kitajima T, Hopp LM, Sumie H (1972) Enhancement of urinary bladder tumorgenesis in hamsters by coadministration of o-acetylaminofluorene and indole. Cancer Res 32:2027
Schubert GE, Steinert M (1978) Das Harnblasenkarzinom im Biopsiegut der vergangenen 50 Jahre. Urologe A 17:361
Stenbaeck F (1980) Characteristics of neoplastic progression and tumor behaviour in skin carcinogenesis by different methods: an experimental study. Oncology 37:163
Voogt PJ de, Rahert P, Beyer-Boon MB (1979) Praxis der Urinzytologie. Springer, Berlin Heidelberg New York
Vutuc C, Kunze M (1979) Rauchgewohnheiten von Blasenkrebspatienten, Versuch zur Quantifizierung der Schadstoff-exposition. Aktuel Urol 10:159
Vutuc C, Kunze M (1981) Quantitative Bestimmung der Zigarettenrauch-Kondensat-Exposition bei männlichen Blasenkarzinompatienten. Aktuel Urol 12:114
Wagle DG, Lee L (1973) Experimental bladder carcinogenesis using cigarette smoke condensate in the rate bladder. J Surg Oncol 5:197
Wang CY, Hayashida S, Pamukcu AM, Bryan GT (1976) Enhancing effect of allopurinol on the induction of bladder cancer in rats by N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide. Cancer Res 36:1551
Weinberg DM, Ross RK, Mack TM, Paganini-Hill A, Henderson BE (1983) Bladder cancer etiology, a different perspective. Cancer 51:675
Weir JM, Dunn JE Jr (1970) Smoking and mortality. A prospective study. Cancer 25:105
Wynder EL, Glodsmith R (1977) The epidemiology of bladder cancer. A second look. Cancer 40:1246
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Adolphs, H.D., Hildenbrand, G., Schwabe, H.W. et al. Urinary cytology in workmen engaged in the petrochemical industry with reference to non-industrial risk factors. Urol. Res. 13, 61–65 (1985). https://doi.org/10.1007/BF00261567
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00261567