Abstract
We analysed the case histories of 22 patients with life threatening asthma retrospectively. Fifteen patients needed mechanical ventilation. Three patients, all of them in cardiac arrest before or at the moment of admission, died. In five patients, halothane therapy was successfully used as a last resort. No major complications occurred. Two case-reports are presented.
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Ambiavagar M, Jones ES (1967) Resuscitation of the moribund asthmatic. Anaesthesia 22:375
Aviado DM (1975) Regulation of bronchomotor tone during anesthesia. Anesthesiology 42:68
Bjertnaes LJ (1977) Hypoxia induced vasoconstriction in isolated perfuses lungs exposed to injectable or inhalation anaesthetics. Acta Anaesth Scand 21:133
Brakensiek AL, Bergman NA (1970) The effects of halothane and atropine on total pulmonary resistance in anesthesized men. Anesthesiology 33:341
Bromage PR (1978) Epidural analgesia. WB Saunders, Philadelphia London Toronto
Cascorbi MF, Redford JE (1983) Toxicity of inhalation anesthetics. Semin Anesth II(2):135
Colaco CM, Crago RR, Weisbert A (1978) Halothane for status asthmaticus in the intensive care unit — a case report. Canad Anesth Soc J 25(4):329
Colgan FJ (1965) Performance of lungs and bronchi during inhalation anesthesia. Anesthesiology 26:778
Coon RL, Kampine JP (1975) Hypocapnic bronchoconstriction and inhalation anesthetics. Anesthesiology 43:635
Crompton GK, Grant IW, Bloomfield P (1979) Edinburgh emergency asthma Admission Service: Report on a ten year experience. Br Med J 2(6199):1199
Cullen DJ, Eger EJ (1977) The effects of halothane in respiratory and cardiovascular responses to hypoxia in dogs. Anesthesiology 33:487
Darioli R, Domenighetti G, Perret C (1981) Ventilation mécanique dans le traitement de l'insuffisance respiratoire aigue de l'état de mal asthmatique. Schweiz Med Wochenschr 111(6):194
D'Athis F (1980) Les effets immunologiques des anesthésiques. Encyclopédie Médico Chriurgicale: Anesthésie-Réanimation 46:1–36840 G-30
Fletcher SW, Flacke W, Alper MH (1968) The action of general anesthetic agents on tracheal smooth muscle. Anesthesiology 29:517
Gold MI, Helrich M (1979) Pulmonary mechanics during general anesthesia: V. Status Asthmaticus. Anesthesiology 32(5):422
Gold MI (1970) Anesthesia for the asthmatic patient. Anesth Analg 49(6):881
Gomez GM, Aguilar GI, Barrales MA, Trevino PJL (1980) Halothane: un recurso mas en el paciente en estado de mal astmatico. Bol Med Hosp Infant Mex 37(2):355
Halttunen PK, Luomanmäki K, Takkunen O, Viljanen AA (1980) Management of severe bronchial asthma in an intensive care unit. Ann Clin Res 12:109
Helm WH, Barran KM, Mukersee SC (1972) Bronchial lavage in asthma and bronchitis. Ann Allergy 30:518
Hickey RF, Graf PD, Nadel JA, Larson CP (1969) The effects of halothane and cyclopropane on total pulmonary resistance in the dog. Anesthesiology 31:334
Hirshman CA, Bergman NA (1978) Halothane and enflurane protect against bronchospasm in asthma dog model. Anesth Analg 57:629
Hirshman CA, Downes H, Farbood DA, Bergman NA (1979) Ketamine block of bronchospasm in experimental canine asthma. Br J Anesth 51(8):713
Hoang PTD, Pourriat JL, Rathat C, Cupa M (1981) L'état de mal asthmatique. Ventilation assistée à l'aide de l'association gamma-hydroxy-butyrate et sodium bromure de pancuronium. Anesth Analg Réan 38:43
Klide AM, Aviado DM (1967) Mechanism for the reduction in pulmonary resistance induced by halothane. J Pharmacol Exp Ther 158:28
Horowitz LN, Spear JF, Moore EN, Rogers R (1975) Effects of aminophylline in the treshold for initiating ventricular fibrillation during respiratory failure. Am J Cardiol 35:376
Mallampati R (1981) Bronchospasm during spinal anesthesia. Anesth Analg 60(11):839
Manawadu BR, Laforce FM (1979) Impairment of pulmonary antibacterial defense mechanisms by halothane anesthesia. Chest 75:242
Mather SJ, Edbrooke DL, Newby DM (1982) Status asthmaticus; management of status asthmaticus complicated by surgical emphysema. Anesthesia 37:738
Merin RG, Kumazawa T, Luka NL (1976) Myocardial function and metabolism in the conscious dog and during halothane anesthesia. Anesthesiology 44(5):402
O'Rourke PP, Crome RK (1982) Halothane in status asthmaticus. Crit Care Med 10:341
Raine JM, Palazzo MG, Herr JH, Sleight P (1981) Near-fatal bronchospasm after oral nadolol in a young asthmatic and response to ventilation with halothane. Br Med J 282:548
Roizen MF, Stevens WC (1978) Multiform ventricular tachycardia due to the interaction of aminophylline and halothane. Anesth Analg 57:738
Runovich AA, Baturin SM, Varnakov AA (1980) Prolonged peridural block in the overall treatment of the infections-allergic form of bronchial asthma. Ventr Khir 125:15
Santiago SM, Klaustermeyer WB (1980) Mortality in status asthmaticus: a nine year experience in a respiratory intensive care unit. J Asthma Res 17:75
Scoggin CH, Sahn SA, Petty TL (1977) Status asthmaticus. JAMA 238:1158
Shnider SM, Papper EM (1961) Anesthesia for the asthmatic patient. Anesthesiology 22:886
Shridiharani M, Maxson TR (1982) Pulmonary lavage in a patient in status asthmaticus receiving mechanical ventilation. Ann Allergy 49:156
Stone JG, Sullivan SF (1972) Halothane anesthesia and pulmonary shunting. Anesthesiology 37:582
Williams MH (1980) Life threatening asthma. Arch Intern Med 140:1604
Zink J, Sasyniuk B, Dresel PE (1975) Halothane-epinephrine induced cardiac arrhythmias and the role of heart rate. Anesthesiology 43:548
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Rosseel, P., Lauwers, L.F. & Baute, L. Halothane treatment in life-threatening asthma. Intensive Care Med 11, 241–246 (1985). https://doi.org/10.1007/BF00260352
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DOI: https://doi.org/10.1007/BF00260352