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A randomised trial of tamoxifen versus tamoxifen with aminoglutethimide in post-menopausal women with advanced breast cancer

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  • Tamoxifen Aminoglutethimide, Breast Cancer
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Summary

Sixty-six post-menopausal women with metastatic breast cancer were randomised to receive tamoxifen or tamoxifen with aminoglutethimide. The women in the tamoxifen group were virtually free of toxicity, whilst 45% of patients in the aminoglutethimide group had toxicity and 13% discontinued the drug because of this. Responses were seen in 19% of patients receiving tamoxifen alone and 23% of those receiving both drugs. There is no indication that the increased toxicity seen with the addition of aminoglutethimide to tamoxifen in this situation is justified by an increased response rate.

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References

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Author notes

  1. R. Milsted

    Present address: C. R. C. Oncology Unit, Southampton General Hospital, Southampton, UK

Authors and Affiliations

  1. Department of Clinical Oncology, Gartnavel General Hospital, 1053 Great Western Road, Glasgow, Scotland

    R. Milsted, S. Kaye, G. Sangster & K. Calman

  2. Department of Radiotherapeutics and Oncology, Western Infirmary, Glasgow, Scotland

    T. Habeshaw

  3. Heathfield Hospital, Ayrshire

    J. Campbell-Ferguson

  4. Victoria Infirmary, Glasgow, Scotland

    D. Smith

  5. C. R. C. Oncology Unit, Southampton General Hospital, Southampton, UK

    F. Macbeth

Authors
  1. R. Milsted
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  2. T. Habeshaw
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  3. S. Kaye
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  4. G. Sangster
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  5. F. Macbeth
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  6. J. Campbell-Ferguson
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  7. D. Smith
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  8. K. Calman
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Milsted, R., Habeshaw, T., Kaye, S. et al. A randomised trial of tamoxifen versus tamoxifen with aminoglutethimide in post-menopausal women with advanced breast cancer. Cancer Chemother. Pharmacol. 14, 272–273 (1985). https://doi.org/10.1007/BF00258132

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  • DOI: https://doi.org/10.1007/BF00258132

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