Summary
The remarkable discovery of alloxan diabetes came about between a Professor of Pathology and an apprentice who was foisted on him. The Professor (J. Shaw Dunn) had a lifetime behind him largely dedicated to studies on the kidney and particularly reno-tubular necrosis. The apprentice (McLetchie), despite overburdening duties and discouragement against endocrine research in wartime, developed a passion for endocrine investigation. A Colonel Sheehan (later to be enshrined in Sheehan's syndrome) in a brief wartime collaboration with the apprentice left him with a vivid description of hypoglycaemia associated with post-partum pituitary necrosis. The apprentice saw this behaviour paralleled in rabbits which had been given alloxan in a vague belief that it would further wartime research on the Crush Kidney syndrome. And so, alloxan diabetes was born. Shaw Dunn achieved some posthumous recognition and World War 2 closed over the other actors in the scene.
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References
McLetchie NGB (1944) On staining the basophil cells of the human hypophysis. J Endocrinol 3: 323–331
McLetchie NGB (1944) The pituitary basophilism syndrome of Harvey Cushing. J Endocrinol 3: 332–346
McLetchie NGB, Scott LDW (1944) Carcinoma of an adreno-cortical rest associated with hypophyseal abnormality. J Endocrinol 3: 347–355
McLetchie NGB (1944) Adrenal virilism, Br J Surg 32: 90–98
Sheehan HL, McLetchie NGB (1945) Simmond's disease due to post-partum necrosis of the anterior pituitary. J Ob Gyn of B.E. 50: 27–30
Dunn JS, Gillespie M, Niven JSF (1941) Renal lesions in the Crush Syndrome. Lancet 2: 549–552
McLetchie NGB (1943) Renal lesions in a case of excessive vomiting. J Path Bact 45: 17–22
Dunn J Shaw, Sheehan HL, McLetchie NGB (1943) Necrosis of the islets of Langerhans produced experimentally. Lancet 1: 484–487
Dunn J Shaw, McLetchie NGB (1943) Experimental alloxan diabetes in the rat. Lancet 2: 384–386
Dunn J Shaw, Kirkpatrick J, McLetchie NGB, Telfer SV (1943) Necrosis of the islets of Langerhans produced experimentally. J Path Bact 45: 245–257
Dunn J Shaw, Duffy E, Gilmour MK, Kirkpatrick J, McLetchie NGB (1944) Further observations on the effects of alloxan on the pancreatic islets. J Physiol 103: 233–243
McLetchie NGB (1942) Studies on the relationship of the basophil cells of the hypophysis to the adrenal cortex. MD Thesis: University of Glasgow
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McLetchie, N.G.B. Alloxan diabetes: The sorcerer and his apprentice. Diabetologia 23, 72–75 (1982). https://doi.org/10.1007/BF00257736
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DOI: https://doi.org/10.1007/BF00257736