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Platinum disposition after intraarterial and intravenous infusion of cisplatin for osteosarcoma

  • Original Articles
  • Cisplatin, Platinum Disposition, Osteosarcoma, Intraarterial, Intravenous
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Summary

Preoperative chemotherapy according to the COSS 86 protocol, including two courses of cisplatin, was used for high-risk osteosarcoma. Patients were randomised to receive either intraarterial (i.a.) or intravenous (i.v.) cisplatin infusions. As measured by flameless atomic absorption spectroscopy (FAAS), platinum (Pt) levels in serum, ultrafiltrate, and urine did not show a decrease in systemic drug availability with i.a. administration. Turmors were surgically removed 3 weeks after the last cisplatin dose and analysed for Pt content and response to chemotherapy. A correlation could not be demonstrated between Pt levels in tumor tissue samples and the mode of CDDP application or extent of tumor cell destruction.

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Authors and Affiliations

  1. Abteilung für pädiatrische Hämatologie und Onkologie, Universitäts-Kinderklinik Hamburg-Eppendorf, Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany

    Stefan S. Bielack, Rudolf Erttmann, Guido Looft, Christine Purfürst, Kurt Winkler & Günther Landbeck

  2. Pathologisches Institut, Universitäts-Krankenhaus Hamburg-Eppendorf, Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany

    Günther Delling

Authors
  1. Stefan S. Bielack
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  2. Rudolf Erttmann
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  3. Guido Looft
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  4. Christine Purfürst
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  5. Günther Delling
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  6. Kurt Winkler
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  7. Günther Landbeck
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Cooperative Osteosarcoma Study Group COSS)

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This work was supported by the “Hamburger Krebsgesellschaft” and the “Bundesministerium für Forschung und Technologie”

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Bielack, S.S., Erttmann, R., Looft, G. et al. Platinum disposition after intraarterial and intravenous infusion of cisplatin for osteosarcoma. Cancer Chemother. Pharmacol. 24, 376–380 (1989). https://doi.org/10.1007/BF00257446

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  • DOI: https://doi.org/10.1007/BF00257446

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