Skip to main content
SpringerLink
Log in

Characterization of right or left ventricular contraction heterogeneity using Fourier phase analysis

Application to a group of patients with severe ventricular arrhythmias

  • Published:
European Journal of Nuclear Medicine Aims and scope Submit manuscript

Abstract

The standard deviation of the first harmonic Fourier phase histogram is an indicator of the contraction heterogeneity of the heart ventricles. This approach has been applied to analyse tomographic blood pool (99mTc) examinations in a group of 32 patients with angiographically verified mainly right (RV) but also left (LV) kinetic disorders in relation to severe ventricular arrhythmias and suspicion of arrhythmogenic right ventricular dysplasia (ARVD). The reference group consisted of ten patients with low probability of cardiac kinetic abnormalities.

Thick tomographic slices including both ventricles have been reconstructed in the horizontal long axis orientation from a series of 32 gated projections recorded over a 360° rotation. Separately for each ventricle the Fourier phase histograms have been computed and characterized by their standard deviations (PSD). Normal values (mean±standard deviation, LV=11°±5°, RV=12°±5°) were significantly lower (P<0.01 and P<0.001) than those measured in abnormal cases (LV=19°±10° and RV=31°±17°).

Detailed analysis of the data supports the hypothesis of a primary RV disease in ARVD, with secondary LV extension. PSD seems to be a good predictor of an organic cardiac disease underlying ventricular arrhythmias and may be used for screening the patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Adam WE, Tarkowska A, Bitter F (1979) Equilibrium gated radionuclide ventriculography. Cardiovasc Radiol 2:161–173

    Google Scholar 

  • Adam WE, Bitter F (1981) Advances in heart imaging. In: IAEA (ed) Medical Radionuclide Imaging, vol. II. Vienna, 1981, pp 195–218

  • Bacharach ST, Green MV, Bonow RO, de Graaf CN, Johnston GS (1982) A method for objective evaluation of functional images. J Nucl Med 23:285–290

    Google Scholar 

  • Baran A, Nanda NC, Falkoff M (1982) Two dimensional echocardiographic detection of arrhythmogenic right ventricular dysplasia. Am Heart J 103:1066–1067

    Google Scholar 

  • Barat JL, Brendel J, Colle JP, Magimel-Pelonnier V, Ohayon J, Wynchank S, Leccia F, Besse P, Ducassou D (1984) Quantitative analysis of left-ventricular function using gated single photon emission tomography. J Nucl Med 25:1167–1174

    Google Scholar 

  • Bigger JT (1983) Definition of benign versus malignant ventricular arrythmias: targets for treatment. Am J Cardiol 52:47C-54C

    Google Scholar 

  • Botvinick E, Frais MA, Shosa D, O'Connel JW, Pacheco-Alvarez JA, Scheinman MM, Hattner RS, Morady F, Faulkner DW (1982) An accurate means of detecting and characterizing abnormal patterns of ventricular activation by phase image analysis. Am J Cardiol 50:289–298

    Google Scholar 

  • Botvinick E, Frais MA, O'Connell W, Faulkner DW, Scheinman MM, Morady F, Sung R, Shosa DW, Dae M (1984) Phase image evaluation of patients with ventricular pre-excitation syndromes. J Am Coll Cardiol 3:799–814

    Google Scholar 

  • Bourguignon MH, Sebag C, Le Guludec O, Davy JM, Laine JF, Slama M, Motte G, Syrota A (1986) Arrhythmogenic right ventricular dysplasia demonstrated by phase mapping of gated equilibrium radioventriculography. Am Heart J 111:997–1000

    Google Scholar 

  • Corbett JR, Jansen DE, Lewis SE (1985) Tomographic gated blood pool radionuclide ventriculography: Analysis of wall motion and left ventricular volumes in patients with coronary artery disease. J Am Coll Cardiol 6:349–358

    Google Scholar 

  • Deconinck F, Bossuyt A, Hermanne A (1979) A cyclic color scale as an essential requirement in functional imaging of periodic phenomena. Med Phys 6:331

    Google Scholar 

  • Dodge HT, Sandler D, Ballew DW, Lord JP (1960) The use of biplane angiocardiography for measurement of left ventricular volume in man. Am Heart J 60:762–768

    Google Scholar 

  • Drobinski G, Verdiere C, Fontaine GH (1985) Diagnostic angiographique des dysplasies ventriculaires droites. Arch Mal Coeur 78:544–551

    Google Scholar 

  • Fauchier JP, Desvaux B, Cosnay P, Raynaud Ph, Phillippe L, Itti R (1985) Troubles du rythme ventriculaire complexes du sujet apparemment sain. Arch Mal Coeur 78:1333–1343

    Google Scholar 

  • Ferlinz J (1977) Measurements of right ventricular volumes in man from single plane cineangiograms. Am Heart J 94:87–90

    Google Scholar 

  • Fontaine G, Guiraudon G, Frank R, Tereau Y, Fillette F, Marcus Fl, Chomette G, Grosgogeat Y (1982) Dysplasie ventriculaire droite arythmogène et maladie de UHL. Arch Mal Coeur 75:361–372

    Google Scholar 

  • Frais MA, Botvinick E, Shosa D, O'Connell JW, Scheinman MM, Hattner RS, Morady F (1982) Phase image characterization of ventricular contraction in left and right bundle branch block. Am J Cardiol 50:95–105

    Google Scholar 

  • Frank R, Fontaine GT, Vedel J, Mialet G, Sol G, Guiraudon G, Guiraudon Y (1978) Electrocardiologie de quatre cas de dysplasie ventriculaire droite arythmogène. Arch Mal Coeur 71:963–972

    Google Scholar 

  • Halphen CH, Beaufils PH, Azancot I, Boudouy P, Manne B, Slama R (1981) Tachycardies ventriculaires récidivantes par dysplasie ventriculaire droite. Arch Mal Coeur 74:1113–1118

    Google Scholar 

  • Kennedy HL, Pescarmona JE, Bouchard RJ, Goldberg RJ, Caralis DG (1982) Objective evidence of occult myocardial dysfunction in patient with frequent ventricular ectopy without clinically apparent heart disease. Am Heart J 104:57–65

    Google Scholar 

  • Legrand V, Rigo P, Smeets JP, Dumuolin JC, Collignon P, Kulbertus HE (1983) Right ventricular myocardial infarction diagnosed by 99m technetium pyrophosphate scintigraphy: clinical course and follow-up. Eur Heart J 4:9–19

    Google Scholar 

  • Lisbona R, Sniderman A, Derbekyan V (1983) Phase and amplitude imaging in the diagnosis of acute right ventricular damage in inferior infarction. Clin Nucl Med 8:517–520

    Google Scholar 

  • Lergeron JM, Itti R, Philippe L, Tauxe N, Charbonnier B, Raynaud P, Brochier M (1984) Apports de la tomographie radioisotopique pour l'etude fonctionnelle cardiaque. Arch Mal Coeur 77:292–300

    Google Scholar 

  • Lown B, Calvert AF, Armington R (1975) Monitoring for serious arrhythmias and high risk of sudden death. Circulation [Suppl III] 51:189–198

    Google Scholar 

  • Manyari D, Klein GJ, Gulamhusein S (1983) Arrhythmogenic right ventricular dysplasia: a generalized cardiomyopathy? Circulation 68:251–257

    Google Scholar 

  • Manyari D, Duff HJ, Kostuk WJ, Belenkie I, Klein GJ, Wyse DG, Mitchell LB, Bougliner D, Guiraudon G, Smith ER (1986) Usefulness of noninvasive studies for diagnosis of right ventricular dysplasia. Am J Cardiol 57:1147–1153

    Google Scholar 

  • Marcus IF, Fontaine GH, Guiraudon G, Frank R, Laurenceau JL, Malergue C, Grosgogeat Y (1982) Right ventricular dysplasia: a report of 24 adult cases. Circulation 65:384–398

    CAS  PubMed  Google Scholar 

  • Marmor A, Geltman EM, Biello DR, Sobel BE, Siegel BA, Roberts R (1981) Functional response of the right ventricle to myocardial infarction: dependence on the site of left ventricular infarction. Circulation 64:1005–1011

    Google Scholar 

  • Nakajima K, Bunko H, Tada A (1985) Nuclear tomographic phase analysis: localization of accessory conduction pathway in patients with Wolff-Parkinson-White syndrome. Am Heart J 109:809–815

    Google Scholar 

  • Nakajima K, Bunko H, Tonami N, Taki J, Nanbu I, Shiire Y, Hisada K, Misaki T, Iwa T (1986) Length-based Fourier analysis in the pre-excitation syndrome. J Nucl Med 27:1131–1137

    Google Scholar 

  • Pavel DG, Zimmer MA, Patterson VN (1977) In vivo labelling of red blood cells with 99mTC: a new approach to blood pool visualisation. J Nucl Med 18:305–308

    Google Scholar 

  • Pavel DG, Briandet PA (1983) Quo Vadis phase analysis. Clin Nucl Med 8:564–575

    Google Scholar 

  • Pavel D, Byrom E, Law W, Meyer-Pavel C, Swiryn S, Pietras R (1983) Detection and quantification of regional wall motion abnormalities using phase analysis of equilibrium gated cardiac studies. Clin Nucl Med 8:315–320

    Google Scholar 

  • Philippe L, Itti R (1981) Premiers resultats de gammatomographie dynamique des cavités cardiaques. C R Acad Sci Paris 292 (serie III):673–676

    Google Scholar 

  • PhilippeL, IttiR, LorgeronJM (1982) Thick slice emission tomography for quantitative assessment of cardiac function. J Nucl Med 23:P 61 (abstr)

    Google Scholar 

  • Pietras RJ, Lam W, Bauernfeind R, Sheikh A, Palileo E, Strasberg B (1983) Chronic recurrent right ventricular tachycardia in patients without ischemic heart disease: clinical, hemodynamic and angiographic findings. Am Heart J 105:357–378

    Google Scholar 

  • Rigo P, Alderson PO, Robertson RM (1978) Measurement of valvular regurgitation by gated cardiac blood pool scans. Circulation [Suppl II] 58:5 (abstr)

    Google Scholar 

  • Robertson JH, Bardy GH, German LD, Becker LC, Wagner HN (1985) Comparison of two-dimsional echocardiographic and angiographic findings in arrhythmogenic right ventricular dysplasia. Am J Cardiol 55:1506–1508

    Google Scholar 

  • Rossi P, Massumi A, Gillette P, Hall RJ (1982) Arrythmogenic right ventricular dysplasia: clinical features, diagnostic techniques, and current management. Am Heart J 103:415–420

    Google Scholar 

  • Stadius ML, Williams DL, Harp G, Cerqueira M, Caldwell JH, Stratton JR, Ritchie JL (1985) Left ventricular volume determination using single-photon emission computed tomography. Am J Cardiol 55:1185–1191

    Google Scholar 

  • Sugrue DD, Holmes DR, Gersh BJ (1984) Cardiac histologic findings in patients with life-threatening ventricular arrhythmias of unknown origin. JACC 4:952–957

    Google Scholar 

  • Swiryn S, Pavel D, Byrom E, Bauernfeind RA, Strasberg B, Palileo E, Lam W, Wynham CRC, Rosen KM (1981) Sequential regional phase mapping of radionuclide gated biventriculograms in patients with left bundle branch block. Am Heart J 102:1000–1010

    Google Scholar 

  • Vos P, Vossepoel A, Beekhuis H (1980) Characterisation of a ventricular function by temporal Fourier transform of gated blood pool studies. Nucl Med Comm 1:10–18

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Trousseau University Hospital, F-37044, Tours Cedex, France

    Roland Itti, Danielle Casset, Laurent Philippe, Jean-Paul Fauchier, Pierre Cosnay & René Huguet

  2. Department of Cardiology, Trousseau University Hospital, F-37044, Tours Cedex, France

    Roland Itti, Danielle Casset, Laurent Philippe, Jean-Paul Fauchier, Pierre Cosnay & René Huguet

Authors
  1. Roland Itti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Danielle Casset
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Laurent Philippe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jean-Paul Fauchier
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Pierre Cosnay
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. René Huguet
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work has been supported by a contract of the National Health Insurance Office of France (Caisse Nationale d'Assurance Maladie des Travailleurs Salariés)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Itti, R., Casset, D., Philippe, L. et al. Characterization of right or left ventricular contraction heterogeneity using Fourier phase analysis. Eur J Nucl Med 14, 196–202 (1988). https://doi.org/10.1007/BF00257327

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00257327

Key words

Search

Navigation