Summary
The nephrotoxic interation between cis-diamminedichloroplatinum (CDDP) and amikacin (AMI) was studied in rats. Following a single dose of CDDP (5 mg/kg i. v.), AMI (60 mg/kg s. c.) was given for 14 days. When given alone CDDP caused a 40% fall in the glomerular filtration rate (GFR), whereas AMI alone had no effect on GFR. This nonnephrotoxic course of AMI potentiated the CDDP-induced fall in GFR. Only a limited recovery of renal function was observed during a 15-week follow-up period.
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This study was supported by a grant from the Dutch Cancer Foundation (Koningin Wilhelmina Fonds)
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Jongejan, H.T.M., Provoost, A.P. & Molenaar, J.C. Potentiation of cis-diamminedichloroplatinum nephrotoxicity by amikacin in rats. Cancer Chemother. Pharmacol. 22, 178–180 (1988). https://doi.org/10.1007/BF00257319
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DOI: https://doi.org/10.1007/BF00257319