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Combined therapeutic effects of an immunomodulator, PSK, and chemotherapy with carboquone on rat bladder carcinoma

  • Original Articles
  • Antitumor Activity, PSK, Carboquone
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Summary

Responses of bladder cancer in ACI rats to combination therapy with an immunomodulator, PSK, and an alkylating agent, carboquone, are reported. PSK is a protein-bound polysaccharide isolated from Basidiomycetes, and carboquone is the alkylating agent 2,5-bis(1-aziridinyl)-3-(2-hydroxy-1-methanoxyethyl)-6-methyl-p-benzoquinone carbornate molecular weight 3,214.

The immunomodulator, PSK, was shown to enhance the effectiveness of the chemotherapeutic agent, carboquone. The therapeutic effect of combination tratment was monitored by measuring growth rates of tumors transplanted SC and by measuring decreases in metastatic spread to lungs in tumor-bearing animals. Effects of PSK on host immunity were monitored by measuring serum levels of immunosuppressive substance.

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  1. Division of Urology, Department of Surgery, The University of North Carolina at Chapel Hill, 428 Burnett-Womack Bldg, 27514, Chapel Hill, NC, USA

    Don D. Mickey

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  1. Don D. Mickey
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Mickey, D.D. Combined therapeutic effects of an immunomodulator, PSK, and chemotherapy with carboquone on rat bladder carcinoma. Cancer Chemother. Pharmacol. 15, 54–58 (1985). https://doi.org/10.1007/BF00257295

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  • DOI: https://doi.org/10.1007/BF00257295

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