Abstract
Deconvolution analysis of radionuclide angiocardiography time-activity curves (TAC) in the cases of fragmented bolus injections was studied by using a new deconvolution technique based on the maximum a posteriori estimator. This method was first tested by simulation studies which showed its capability for accurate handling of deconvolution both for single and double peak input functions. These simulations have proved this technique to have advantages over a Fourier transform division method used with a low-pass filter. In patient studies, deconvolution of pulmonary TAC by superior vena caval TAC produced poor results in double peak (fragmented) bolus injections, compared with single peak bolus injections (SPBI). This discrepancy seems to be due to the fact that the postulates of linearity and invariance, on which deconvolution analysis is based, do not hold for the ‘cardiopulmonary system’ which extends from the superior vena cava to the lung. The differences between the model and the real system appear unimportant for SPBI. However, differences become apparent for fragmented bolus injections. Deconvolution analysis should be avoided with this type of input function in this cardiopulmonary system.
Similar content being viewed by others
References
Alderson PO, Douglass KH, Mendenhall KG, Guadini VA, Watson DC, Links JM, Wagner HN (1979) Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts. J Nucl Med 20:502–506
Alderson PO, Douglass KH, Roland JM, Links JM, Foard PM, Leitl GP, Wagner HN (1980) Routine deconvolution analysis of pulmonary transit curves in patients with suspected left-right cardiac shunts. J Nucl Med 21: Proceedings of the 27th annual meeting, p8
Beck JV, Arnold KJ (1977) Parameter estimation in engineering and science. John Wiley, New York, p 271–274
Brendel AJ, Commenges D, San Galli F, Salamon R, Ducassou D (1981) Deconvolution des courbes de transit pulmonaire de gamma-angiocardiographie pour le calcul des shunts cardiaques: étude d'une nouvelle méthode — limitations d'ordre théorique. Proceedings 22th Colloque de Médecine Nucléaire de Langue Française, Toulouse, p 59–60
Commenges D (1982) A new deconvolution technique and its application to the study of vascular systems. Proceedings 6th IFAC symposium on Identification and System Parameter Estimation, Washington, p 1272–1275
Commenges D, Brendel AJ (1982) A deconvolution program for processing radiotracer dilution curves. Comput Progr Biomed 14:271–276
Crump ND (1974) A Kalman filter approach to the deconvolution of seismic signals. Geophysics 39:1–13
De Graaf CN, Van Rijk PP, Harinck E (1976) A non invasive technique for quantitative detection of cardiac left-to-right shunts by least-squares gamma variate fitting of deconvoluted radioisotope dilution curves. Proceedings Conference Computers in Cardiology, St Louis, MO, IEEE 76 CH 1160-1C, p 275–280
Ham HR, Dobbeleir A, Viart P, Piepsz A, Lenaers A (1981) Radionuclide quantitation of left-to-right cardiac shunts using deconvolution analysis. J Nucl Med 22:688–692
Maltz DL, Treves S (1973) Quantitative radionuclide angiocardiography. Determination of QP:QS in children. Circulation 47:1049–1056
Papoulis A (1977) Signal analysis. Mc Graw-Hill, New York, p 12–25
Snedecor GW, Cochran WG (1980) Statistical methods, 7th edition. Iowa State University Press, Ames, Iowa, p 141–145
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brendel, A.J., Commenges, D., Salamon, R. et al. Deconvolution analysis of radionuclide angiocardiography curves: Problems arising from fragmented bolus injections. Eur J Nucl Med 8, 93–98 (1983). https://doi.org/10.1007/BF00256729
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00256729