Summary
The renal function was studied 24 h after a 2 h thrombin infusion in rats with inhibition of the fibrinolytic system. The functional changes found were decreased osmolar and negative free water clearances, increased serum osmolarity, increased rejection of Na and elevated Na/K quotient in the urine. The glomerular filtration rate was markedly reduced.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Beller, F. K., Graeff, H., Gorstein, F.: Disseminated intravascular coagulation during the continous infusion of endotoxin in rabbits. Morphologic and physiologic studies. Amer. J. Obstet. Gynec. 103, 544 (1969)
Brain, M. C., Dacie, J. V., Hourikane, D. O. B.: Microangiopathic haemolytic anemia: The possible role of vascular lesions in the pathogenesis. Brit. J. Haemat. 8, 358 (1962)
Busch, G. J., Braun, W. E., Carpenter, C. B., Corson, J. M., Galvanek, E.R., Reynolds, E. S., Merrill, J. P., Dammin, G. J.: Intravascular coagulation in human renal allograft rejection. Transpl. Proc. 1, 267 (1969)
Clarkson, A. R., MacDonald, M. K., Fuster, V., Casch, J. D., Robson, J. S.: Glomerular coagulation in acute ischaemic renal failure. Quart. J. Med. 39, 585 (1970)
Høie, J. and Schenck, W. C.: Experimental intravascular coagulation: Impairment of renal blood flow following thrombin infusion in the dog. J. Trauma 12, 302 (1972)
Kincaid-Smith, P., Laver, M. C., Fairly, K. F., Mathews, D. C.: Dipyridamole and anticoagulants in renal disease due to glomerular and vascular lesions. A new approach to therapy. Med. J. Aust. 145 (1970)
Larsson, S. O., Hedner, U., Nilsson, I. M.: On fibrinolytic split products in serum and urine in uraemia. Scand. J. Urol. Nephrol. 5, 234 (1971)
Margaretten, W., Zunker, H. O., McKay, D. G.: Production of the generalized Shwartzman reaction inpregnant rats by intravenous infusion of thrombin. I. Lab. Invest. 13, 552 (1964)
Morris, R. H., Vassalli, P., Beller, F. K., McCluskey, R. T.: Immunofluorescent studies of renal biopsies in the diagnosis of toxemia of pregancy. Obstet. and Gynec. 24, 32 (1964)
Rådegran, K., Cronestrand, R., Olsson, P.: The effect of regional thrombin infusion on the renal vascular resistance. Europ. Surg. Res. 2, 460 (1970)
Rammer, L.: Intravascular coagulation, fibrinolysis inhibition and posttraumatic renal failure. A study in burned rats. Acta Universitatis Upsaliensis, 116 (1972)
Rammer, L., Busch, C., Diffang, C., Saldeen, T.: Amount of intravascular fibrin in various organs of the rat after intravenous infusion of thrombin. Forens. Sci. 1, 115 (1972)
Thiess, W., Graeff, H., Bleyl, U., Immich, H., Kuhn, W.: Reversible stadien intravasculären Gerinnung und ihre Auswirkungen auf Nierenfunktion und Urokinaseausscheidung. Thrombos. Diathes. haemorrh. (Stuttg.) 23, 369 (1970)
Thurau, K., Schneerman, J.: Die Natriumkoncentration an den Maculadensazellen als regulierender Faktor für das Glomerulumfiltrat (Mikropunktionsversuche). Klin. Wschr. 43, 410 (1965)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rammer, L. Renal function after intravascular coagulation in the rat kidney. Urol. Res. 1, 166–169 (1973). https://doi.org/10.1007/BF00256618
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00256618