Summary
Lipoperoxidation appears to play a role in inducing aflatoxin biosynthesis. In vitro, synthetic lipoperoxides greatly stimulate aflatoxin production when added to cultures of toxigenic strains of Aspergillus parasiticus or A. flavus. In vivo, the amount of toxin formed in sunflower seeds of different ages inoculated with A. parasiticus is directly related to the peroxide number of their oil content: the higher the peroxide number, the higher the aflatoxin production. In cultures of A. parasiticus carbon tetrachloride (CCl4) greatly stimulates aflatoxin biosynthesis. This effect might be due to the peroxidation of lipids of the endoplasmic reticulum of Aspergillus by the highly reactive CCl 3. radicals formed by interaction with the NADPH-cytochrome P-450 system.
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References
Anonimous (1976) Norme italiane per il controllo dei grassi e derivati (III edn). Stazione sperimentale per le Industrie degli oli e grassi ed
Bhatnagar RK, Ahmad S, Kohli KK, Mukerji KG, Venkitasubramanian TA (1982) Induction of polysubstrate monoxygenase and aflatoxin production by phenobarbitone in Aspergillus parasiticus. Biochem Biophys Res Commun 104:1287–1292
Cortesi R, Privett OS (1972) Toxicity of fatty ozonides and peroxides. Lipids 7:715–719
Del Maestro RF (1980) An approach to free radicals in medicine and biology. Acta Physiol Scand [Suppl] 492:153–168
Fabbri AA, Fanelli C, Serafini M (1980) Aflatoxin production on cereals, oil seeds and some organic fractions extracted from sunflower. Rendiconti Accademia Nazionale delle Scienze detta dei XL 98:219–228
Fanelli C, Fabbri AA, Passi S (1980) Growth requirements and lipid metabolism of Aspergillus flavus. Trans Br Mycol Soc 75:371–375
Fanelli C, Fabbri AA, Finotti E, Bellincampi D, Gualandi G, Passi S (1982) Induction of the biosynthesis of aflatoxins in Aspergillus parasiticus by Cerulenin. Proceedings of Vth International IUPAC Symposium on Mycotoxins and Phycotoxins, Vienna, September 1–3, 1982, pp 166–169
Fanelli C, Fabbri AA, Finotti E, Passi S (1983a) Stimulation of aflatoxin biosynthesis by lipophilic epoxides. J Gen Microbiol 129:1721–1723
Fanelli C, Fabbri AA, Finotti E, Panfili G, Passi S (1983b) Cerulenin and tetrahydrocerulenin: stimulating factors of aflatoxin biosynthesis. Trans Br Mycol Soc 8:201–204
Frankel EN (1980) Lipid oxidation. Proc Lipid Res 19:1–22
Hamberg M, Samuelsson B (1965) On the specificity of the lipoxidase catalyzed oxygenation of unsaturated fatty acids. Biochem Biophys Res Commun 21:531–536
Jenner S, Netter KJ (1972) On the inhibition of microsomal drug metabolism by SKF-A. Biochem Pharmacol 21:1921–1930
Lee IP, Yamamura HI, Dixon RL (1968) The effects of β-diethylaminoethyldiphenil propylacetate (SKF 525 A) on biological membranes I. Biochem Pharmacol 17:1671–1681
Orrenius S, Ernster L (1964) Phenobarbital-induced synthesis of the oxidative demethylating enzymes of rat liver microsomes. Biochem Biophys Res Commun 16:60–64
Recknagel RO, Glende Jr, EA, Hruszkewycz AM (1977) Chemical mechanisms in carbontetrachloride toxicity. In: Pryor AA (ed) Free radicals in biology, vol 3. Academic Press, New York, pp 97–132
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Passi, S., Nazzaro-Porro, M., Fanelli, C. et al. Role of lipoperoxidation in aflatoxin production. Appl Microbiol Biotechnol 19, 186–190 (1984). https://doi.org/10.1007/BF00256452
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DOI: https://doi.org/10.1007/BF00256452