Summary
Peritumoural inflammation consisting of lymphocytes, plasma cells and lymph follicles is present in two thirds of invasive urothelial bladder carcinomas. This type of inflammation is significantly rarer in advanced tumour stages (P3, P4) and its presence is a favourable prognostic factor. The mean survival time in patients with this type of inflammation is 26.1 months compared to only 14.8 months in patients without. All other forms of inflammation e. g. eosinophilic or polymorphonuclear leukocytes have no relation with prognosis. The significant prognostic value of lympho-plasmocytic inflammation may be considered as local expression of immunological host resistance.
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Bean, M. A., Bloom, B. R., Herberman, R. B., Old, L. J., Oettgen, H. F., Klein, G., Terry, W. D.: Cell mediated cytotoxicity for bladder carcinoma: Evaluation of a workshop. Cancer Research 35, 2902 (1975)
Bean, M. A., Pees, H., Fogh, J. E., Grabstald, H., Oettgen, H. F.: Cytotoxicity of lymphocytes from patients with cancer of the urinary bladder: Detection by a H3-proline microcytotoxicity test. International Journal of Cancer 14, 186 (1976)
Berg, J.: Inflammation and prognosis in breast cancer. A search for host resistance. Cancer 12, 714 (1963)
Black, M. M.: Human breast carcinoma. New York State Journal of Medicine 70, 962 (1970)
Black, M. M., Asire, A. J.: Palpable axillary lymph nodes in cancer of the breast: Structural and biological considerations. Cancer 23, 251 (1969)
Black, M. M., Speer, F. D.: Structural representation of tumor-host relationship in gastric carcinoma. Surgery, Gynecology and Obstetrics 102, 599 (1956)
Bubenik, J., Perlmann, P., Helmstein, K., Moberger, G.: Cellular and humoral immune response to human urinary bladder carcinomes. International Journal of Cancer 5, 310 (1970)
Catalona, W. J., Torpley, J. L., Chretien, B. P., Castle, J. R.: Lymphocyte stimulation in urologic cancer patients. Journal of Urology 112, 373 (1974)
Chretien, P. B., Crowder, W. L., Gartner, H. R., Sample, W. F., Catalona, W. J.: Correlation of preoperative lymphocyte reactivity with the clinical course of cancer patients. Surgery, Gynecology and Obstetrics 136, 380 (1973)
Cutler, S. J., Black, M. M., Mark, J.: Further observations on prognostic factors in cancer of the female breast. Cancer 24, 653 (1969)
Cutler, S. J., Ederer, F.: Maximum utilization of the life table method in analyzing survival. Journal of Chronic Diseases 8, 699 (1958)
Decenzo, J. M., Howard, P., Irish, C. E.: Antigenic deletion and prognosis of patients with stage A transitional cell bladder carcinoma. Journal of Urology 114, 874 (1975)
Dayan, A. G.: Spontaneous regression of cancer. Lancet 2, 1083 (1966)
Eilber, F. R., Morton, D. L.: Impaired immunologic reactivity and recurrence following cancer surgery. Cancer 25, 362 (1970)
Good, R. A.: The lymphoid system, immunodificiency and malignancy. In: Advances in Biosciences, Vol. 12, p. 123. Schering-Symposium on Immunopathology. Braunschweig: Vieweg 1974
Hakala, T. R., Lange, P. H., Castro, A. E., Elliott, A. Y., Fraley, E. E.: Antibody induction of lymphocyte-mediated cytotoxicity against human transitional-cell carcinomas of the urinary bladder. New England Journal of Medicine 291, 637 (1974)
Hellström, J., Hellström, K. E., Evans, C. A., Heppner, G., Pierce, G. E., Yang, J. P. S.: Serum mediated protection of neoplastic cells from inhibition by lymphocytes immune to their tumor specific antigens. Proceedings of the National Academy of Science 62, 263 (1969)
Hellström, J., Hellström, K. E.: Cell mediated immune reactions to tumor antigens with particular emphasis on immunity to human neoplasms. Cancer (Suppl.) 34, 1461 (1974)
Herr, H. W.: Immunobiology of human bladder cancer. Journal of Urology 115, 147 (1976)
Johansson, B., Ljungqvist, A.: Localization of immunoglobulins in urinary bladder tumours. Acta Pathologica et Microbiologica Scandinavica 82, 559 (1974)
MacCarty, W. C., Mahle, A. E.: Relation of differentiation and lymphocytic infiltration to postoperative survival in gastric carcinoma. Journal of Laboratory and Clinical Medicine 6, 473 (1971)
O'Toole, C., Perlmann, D., Unsgaard, B., Almgard, L. E., Johansson, B., Moberger, G., Edmyr, F.: Cellular immunity to human urinary bladder carcinoma. II. Effect of surgery and pre-operative irradiation. International Journal of Cancer 10, 92 (1972)
O'Toole, C., Perlmann, P., Unsgaard, B., Moberger, G., Edsmyr, F.: Cellular immunity to human urinary bladder carcinoma. I. Correlation to clinical stage and radiotherapy. International Journal of Cancer 10, 77 (1972)
Penn, J.: Malignancies in recipients of organ transplants. Johns Hopkins Medical Journal (Suppl.) 13, 211 (1974)
Sarma, K. P.: The role of lymphoid reaction in bladder cancer. Journal of Urology 104, 843 (1970)
Steiner, P. E., Moimon, S. N., Palmer, W. L., Kirzner, J. B.: Gastric cancer: morphologic features in five year survival after gastrectomy. American Journal of Pathology 24, 947 (1948)
Willis, R. A.: The Spread of Tumours in the Human Body. London: Churchill 1934
Zamcheck, N., Doos, W. G., Prudente, R., Lurie, B. B., Gottlieb, L. S.: Prognostic factors in colon carcinoma. Human Pathology 6, 31 (1975)
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Mihatsch, M.J., Rist, M., Romppanen, T. et al. Prognostic significance of peritumoural inflammation in invasive urothelial bladder carcinoma. Urol. Res. 7, 97–102 (1979). https://doi.org/10.1007/BF00254688
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DOI: https://doi.org/10.1007/BF00254688