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In vitro colony inhibition of carboplatin against stomach and lung cancer cell lines in comparison with cisplatin

  • Original Articles
  • Carboplatin, Lung Cancer, Cisplatin, Stomach Cancer
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Summary

The effects of carboplatin and cisplatin on colony formation in stomach and lung cancer cell lines were examined and compared. The colony-inhibitory activity of carboplatin against stomach and lung cancer cell lines was similar to that of cisplatin when one-tenth of the peak plasma concentration of each drug was used (r=0.80). One of the four stomach cancer cell lines was sensitive to carboplatin although all the stomach cancer cell lines were resistant to cisplatin. Of the three small cell lung cancer cell lines tested, two were sensitive to both carboplatin and cisplatin; and only one cell line (N857) was resistant to cisplatin; all the non-small cell cancer cell lines tested were resistant to both drugs. On the basis of these preliminary results, we suggest that carboplatin has potential therapeutic activity against stomach cancer and should be evaluated carefully from this aspect.

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Authors and Affiliations

  1. Department of Internal Medicine, National Cancer Center Hospital, 1-1, Tsukiji 5-chome, Chuo-ku, 104, Tokyo, Japan

    Hidenobu Takahashi, Yasutsuna Sasaki, Nagahiro Saijo, Masanori Sakurai, Hidehiko Nakano, Kazuhiko Nakagawa & Akio Hoshi

  2. Pharmacology Division, National Cancer Center Research Institute, 1-1, Tsukiji 5-chome, Chuo-ku, 104, Tokyo, Japan

    Hidenobu Takahashi, Yasutsuna Sasaki, Nagahiro Saijo, Masanori Sakurai, Hidehiko Nakano, Kazuhiko Nakagawa & Akio Hoshi

  3. Division of Thoracic Disease, Mayo Clinic, 200 First Street, 55905, S. W. Rochester, MN, USA

    James R. Jett

  4. Department of Internal Medicine, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Dobong-ku, 130-02, Seoul, Korea

    Weon-Seon Hong

Authors
  1. Hidenobu Takahashi
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  2. Yasutsuna Sasaki
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  3. Nagahiro Saijo
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  4. Masanori Sakurai
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  5. Hidehiko Nakano
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  6. Kazuhiko Nakagawa
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  7. Akio Hoshi
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  8. James R. Jett
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  9. Weon-Seon Hong
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Additional information

This work was supported in part by a grant-in-aid for cancer research from the Comprehensive Ten-Year Strategy for Cancer Control, from the Ministry of Health and Welfare, and from the Adult Disease Clinic Memorial Foundation. JRJ's and WSH's visits were supported, as part of the visiting scientist program, by the Foundation for Program of Cancer Research based on the Comprehensive Ten-Year Strategy for Cancer Control

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Takahashi, H., Sasaki, Y., Saijo, N. et al. In vitro colony inhibition of carboplatin against stomach and lung cancer cell lines in comparison with cisplatin. Cancer Chemother. Pharmacol. 19, 197–200 (1987). https://doi.org/10.1007/BF00252972

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  • DOI: https://doi.org/10.1007/BF00252972

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