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Reduction of vincristine toxicity by Cronassial

  • Original Articles
  • Vincristine, Cronassial
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Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

A mixture of gangliosides (Cronassial) protects against the chronic but not the acute lethal toxicity of vincristine in mice and affords some protection against the acute lethal toxicity of vincristine in chicks. The protective effect of Cronassial appears to be greatest near the LD50 of vincristine and then diminishes as the dose of vincristine increases further. Cronassial does not, however, reduce the vincristine antitumour activity, so that the net effect is an improvement in the vincristine therapeutic index. Clinical trials are underway to examine the effect of the combination on the development of neurotoxicity in cancer patients.

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Authors and Affiliations

  1. Radiotherapy and Oncology Department, Westminster Hospital, SW1 P2AP, London, UK

    K. Hellmann

  2. Cancer Chemotherapy Department, Imperial Cancer Research Fund, WC2 A3PX, London, UK

    G. E. Hutchinson

  3. Charing Cross and Westminster Hospital Medical Schools, SW1 P2AP, London, UK

    K. Henry

Authors
  1. K. Hellmann
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  2. G. E. Hutchinson
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  3. K. Henry
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Hellmann, K., Hutchinson, G.E. & Henry, K. Reduction of vincristine toxicity by Cronassial. Cancer Chemother. Pharmacol. 20, 21–25 (1987). https://doi.org/10.1007/BF00252954

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  • DOI: https://doi.org/10.1007/BF00252954

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