Abstract
We used a combination of bone and bone-marrow scintigraphy to study 25 patients with prostatic cancer. Of the 18 cases whose 99mTc-methylene diphosphonate (MDP) bone scans showed hot spots in the lower lumbar region of the spine and/or the pelvic bone, 8 had normal bone-marrow scintigrams. These 8 patients were subsequently shown to have senile, degenerative changes of the spine. On the other hand, in 9 of the 10 patients whose bone-marrow scintigrams showed accumulation defects, follow-up study and characteristic X-ray findings confirmed the presence of metastases. In all 6 cases with extensive bone metastases shown by 99mTc-MDP bone scintigraphy, 99mTc-sulphur-colloid bone-marrow scintigraphy showed multiple accumulation defects. In conclusion, bone-marrow scintigraphy was found to be useful in distinguishing metastatic lesions from benign degenerative changes in the cases with suspected bone involvement, as well as in evaluating equivocal lesions in the pelvis.
Similar content being viewed by others
References
Borak J (1942) Relationship between the clinical and roentgenological findings in bone metastasis. Surg Gynecol Obstet 75:599–604
Corcoran RJ, Thrall JH, Kyle RW, Kaminski RJ, Johnson MC (1976) Solitary abnormalities in bone scan of patients with extraosseous malignancies. Radiology 121:663–667
Francis MD, Russel RGG, Fleisch H (1969) Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo. Science 165:1264–1266
Guillemart A, Besnard JC, Pape AL, Galy G, Fetissoff F (1978) Skeletal uptake of pyrophosphate labeled with technetium-95 m and technetium-96, as evaluated by autoradiography. J Nucl Med 19:895–899
Ito Y, Okuyama S, Suzuki M, Sakurai M, Sato T, Takagi H (1973) Bone marrow scintigraphy in the early diagnosis of experimental metastatic bone carcinoma. Cancer 31:1222–1230
Ito Y, Muranaka A, Nagai K, Otsuka N, Nishishita S, Uchida M, Kaji K (1980) 99mTc-Colloid kits from the viewpoint of the accretion in the bone marrow with special reference to comparison with 198Au-colloid. Eur J Nucl Med 5:319–326
Osmond JD, Pendergrass HP, Potsaid MS (1975) Accuracy of 99mTc-diphosphonate bone scans and roentgenograms in the detection of prostate, breast and lung carcinoma metastases. Am J Roentgenol Radium Ther Nucl Med 125:972–977
Sy WM, Patel K, Faunce H (1975) Significance of absent or faint kidney sign on bone scan. J Nucl Med 16:454–456
Thrupkaew AK, Henkin RE, Quinn JL (1974) False negative bone scans in disseminated metastatic disease. Radiology 113:383–386
Tofe AJ, Francis MD, Harvey WJ (1975) Correlation of neoplasms with incidence and localization of skeletal metastases: An analysis of 1,355 diphosphonate bone scans. J Nucl Med 16:986–989
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Otsuka, N., Fukunaga, M., Sone, T. et al. The usefulness of bone-marrow scintigraphy in the detection of bone metastasis from prostatic cancer. Eur J Nucl Med 11, 319–322 (1985). https://doi.org/10.1007/BF00252345
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00252345