Abstract
The labelling of o-iodo-hippuric acid (hippuran) with 123I by several methods was investigated with a view to producing a simple one-step kit preparation. The requirements for the final product are high labelling efficiency and high radiochemical purity. A method which incorporates CuSO4·5H2O as a catalyst was found which gave promising preliminary results. Such variables as pH, mass of CuSO4·5H2O, volume of 0.02 N NaOH containing the 123I, reaction temperature and time were investigated in detail and optimum values obtained. The results have led to the production of a kit which can be stored for up to 3 months in liquid form and up to 9 months if freeze-dried. The kit has been used in several thousand patients and has yielded consistently good clinical results.
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References
Barker F (1978) 123I-Hippuran: A study of radioiodination techniques and radiochemical impurities. M.Sc. Thesis, University of London
Britton KE (1980) Advances in dynamic renal imaging—invited review International Symposium on Medical Radionuclide Imaging, Heidelberg, 1–5 September
Britton KE, Brown NJC (1971) Clinical Renography. Lloyd-Luke, London
Cunninghame JG, Hill JIS, Nichols AL, Taylor NK (1978) The production of iodine-123 on the Harwell Variable Energy Cyclotron, A.E.R.E., Harwell. H.M. Stationery Office
Elias H, Arnold CH, Kloss G (1973) Preparation of 131I-labelled m-iodo-hippuric acid and its behaviour in kidney function studies compared to o-iodo-hippuric acid. Int J Appl Radiat Isot 24:463–469
Elliott AT, Britton KE (1978) A review of the physiological parameters in the dosimetry of 123I and 131I-labelled hippuran. Int J Appl Radiat Isot 29:571–573
Gillet R, Cogneau M, Malhy C (1976) The preparation of 123I-labelled sodium ortho-iodo hippurate for medical research. Int J Appl Radiat Isot 27:61–62
Hinkle CH, Basmadjian CP, Kirschner AS, Ice RD (1980) A radiopharmaceutical kit preparation of 123I-iodo-hippuran. Nucl Med Commun 1:302–306
Hoey CN, Peckels DR, Wiegert PE (1974) Catalyzed radioiodine exchange. United States Patent Office 3:814–769
O'Reilly PH, Herman KJ, Lawson RS, Shields RA, Testa HJ (1977) 123Iodine, a new isotope for functional renal scanning. Br J Urol 49:15–21
O'Reilly PJ, Shields RA, Testa HJ (1979) Nuclear medicine in urology and nephrology. Butterworths, London p 11
Thakur ML, Chauser BM, Hudson, RF (1975) The preparation of iodine-123 labelled ortho-iodo hippurate and its clearance by the rat kidneys. Int J Appl Radiat Isot 26:319–320
Wanek PM, Hupf HB, O'Brien Jr HA (1977) Rapid quantitative radioiodination of o-iodo-hippuric acid. (Abstract). J Nucl Med 18:638
Zielinski F, Robinson GD, Bocksrucker AV, Easton M, Lee AV (1976) First international Symposium on radiopharmaceutical chemistry
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Hawkins, L., Elliott, A., Shields, R. et al. A rapid quantitative method for the preparation of 123I-iodo-hippuric acid. Eur J Nucl Med 7, 58–61 (1982). https://doi.org/10.1007/BF00251643
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DOI: https://doi.org/10.1007/BF00251643