Summary
In anesthetized and paralyzed cats, the normal alignment of the visual axes is disturbed by paralysis of the eye muscles. Thus, the separation between paired receptive fields of binocular cells in visual cortex is increased (paralysis squint). This increased separation is normally tolerated by the majority of visuocortical cells, about 80% of them being binocularly driven (Hubel and Wiesel 1962). It was shown previously that neuronal plasticity in visual cortex can be enhanced in both normal adult cats (Kasamatsu et al. 1979) and kittens (Kuppermann and Kasamatsu 1984) by intracortical microinfusion of noradrenaline (NA). In the present study we tested whether the usual range of disparity produced by the paralysis squint is sufficient to induce ocular dominance changes in visual cortex of adult cats when the neuronal plasticity is enhanced by NA. NA was continuously infused into visual cortex throughout the experiments. The period of the paralysis squint varied from experiment to experiment between 9 and 47 h. We found: (1) These short periods were sufficient to produce a marked reduction in the proportion of binocular cells. (2) The proportion decreased linearly with increasing the duration of the squint period at a rate of 0.17 per 10 h up to about 22 h. (3) At longer durations the average binocularity remained at about 0.30 and could not be further reduced in the present paradigm. (4) The binocularity seemed to decrease with increasing separation of paired receptive fields. (5) Binocularity increased again toward the normal value after optical correction of the squint. (6) The amount of increased binocularity was linearly correlated with the duration of the period after the squint correction. (7) The binocularity increased at a rate of 0.18 per 10 h, reaching the normal value in less than 30 h. We thus concluded that if visuocortical plasticity is maintained at a high level through the continuous infusion of NA it is possible to change the ocular dominance distribution in the mature visual cortex by manipulations of the alignment of the visual axes even in the acutely anesthetized and paralyzed condition.
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References
Barlow HB, Blakemore C, Pettigrew JD (1967) The neural mechanism of binocular depth discrimination. J Physiol (Lond) 193: 327–342
Bear MF, Singer W (1986) Modulation of visual cortical plasticity by acetylcholine and noradrenaline. Nature 320: 172–176
Blakemore C, Pettigrew JD (1970) Eye dominance in the visual cortex. Nature 225: 426–429
Cynader M (1979) Interocular alignment following visual deprivation in the cat. Invest Ophthalmol Visual Sci 18: 726–741
Fiorentini A, Maffei L (1974) Changes of binocular properties of the simple cells of the cortex of adult cats following immobilization of one eye. Vision Res 14: 217–218
Freeman RD, Bonds AB (1979) Cortical plasticity in monocularly deprived immobilized kittens depends on eye movement. Science 206: 1093–1095
Heggelund P, Kasamatsu T (1981) Exogeneous noradrenaline increases the neuronal plasticity in cat visual cortex: localized, continuous microperfusion and iontophoresis. In: Fehér O, Joó F (eds) Advances in physiological sciences, Vol 36. Cellular analogues of conditioning and neural plasticity. Pergamon, Oxford, pp 233–242
Hubel DH, Wiesel TN (1962) Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. J Physiol (Lond) 160: 106–154
Hubel DH, Wiesel TN (1965) Binocular interaction in striate cortex of kittens reared with artificial squint. J Neurophysiol 28: 1041–1059
Hubel DH, Wiesel TN (1970) The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J Physiol (Lond) 206: 419–436
Imamura K, Kasamatsu T (1986) Noradrenergic and cholinergic interaction in ocular dominance plasticity. Soc Neurosci Abstr 12: 1372
Jonsson G, Kasamatsu T (1983) Maturation of monoamine neurotransmitters and receptors in cat occipital cortex during postnatal critical period. Exp Brain Res 50: 449–458
Kasamatsu T (1983) Neuronal plasticity maintained by the central norepinephrine system in the cat visual cortex. In: Sprague JM, Epstein AN (eds) Progress in psychobiol physiol psychol, Vol 10. Academic Press, New York, pp 1–112
Kasamatsu T (1987) Norepinephrine hypothesis for visual cortical plasticity: thesis, antithesis, and recent development. In: Hunt RK, Moscona AA, Monroy A (eds) Current topics in developmental biology, Vol 21. Academic Press, New York, pp 367–389
Kasamatsu T, Heggelund P (1981) Norepinephrine iontophoresis in cat visual cortex: a quick change in ocular dominance. Soc Neurosci Abstr 7: 142
Kasamatsu T, Itakura T, Jonsson G (1981) Intracortical spread of exogeneous catecholamines: effective concentration for modifying cortical plasticity. J Pharmacol Exp Ther 217: 841–850
Kasamatsu T, Itakura T, Jonsson G, Heggelund P, Pettigrew JD, Nakai K, Watabe K, Kuppermann BD, Ary M (1984) Neuronal plasticity in cat visual cortex: a proposed role for the central norepinephrine system. In: Descarries L, Reader TA, Jasper HH (eds) Monamine innervation of cerebral cortex. Alan R Liss, New York, pp 301–319
Kasamatsu T, Pettigrew JD (1976) Depletion of brain catecholamine: failure of ocular dominance shift after monocular occlusion in kittens. Science 194: 206–209
Kasamatsu T, Pettigrew JD, Ary M (1979) Restoration of visual cortical plasticity by local microperfusion of norepinephrine. J Comp Neurol 185: 163–182
Kasamatsu T, Watabe K, Heggelund P, Schöller E (1985) Plasticity in cat visual cortex restored by electrical stimulation of the locus coeruleus. Neurosci Res 2: 365–386
Kuppermann BK, Kasamatsu T (1984) Enhanced binocular interaction in the visual cortex of normal kittens subjected to intracortical norepinephrine perfusion. Brain Res 320: 91–99
Levick WR (1972) Another tungsten microelectrode. Med Biol Eng 10: 510–515
Maffei L, Bisti S (1976) Binocular interaction in strabismic kittens deprived of vision. Science 191: 579–580
Maffei L, Fiorentini A (1976) Asymmetry of motility of the eyes and change of binocular properties of cortical cells in adult cats. Brain Res 105: 73–78
Olson CR, Freeman RD (1978) Eye alignment in kittens. J Neurophysiol 41: 848–859
Pettigrew JD, Kasamatsu T (1978) Local perfusion of noradrenaline maintains visual cortical plasticity. Nature 271: 761–763
Singer W, Tretter F, Yinon U (1979a) Inverted monocular vision prevents ocular dominance shift in kittens and impairs the functional state of visual cortex in adult cats. Brain Res 164: 294–299
Singer W, v Gruenau, Rauschecker J (1979b) Requirements for the disruption of binocularity in the visual cortex of strabismic kittens. Brain Res 171: 536–540
Tsumoto T, Freeman RD (1981) Ocular dominance in kitten cortex: induced changes of single cells while they are recorded. Exp Brain Res 44: 347–351
Van Sluyters RC, Levitt FB (1980) Experimental strabismus in the kitten. J Neurophysiol 43: 686–699
Wiesel TN, Hubel DH (1963) Single-cell responses in striate cortex of kittens deprived of vision in one eye. J Neurophysiol 26: 1003–1017
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Heggelund, P., Imamura, K. & Kasamatsu, T. Reduced binocularity in the noradrenaline-infused striate cortex of acutely anesthetized and paralyzed, otherwise normal cats. Exp Brain Res 68, 593–605 (1987). https://doi.org/10.1007/BF00249802
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DOI: https://doi.org/10.1007/BF00249802