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Alkylphosphatvergiftung und 5-Hydroxytryptamin-Stoffwechsel des Zentralnervensystems

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Zusammenfassung

Unter Vergiftung mit Alkylphosphaten bei verschiedenen Dosierungs-bedingungen wurde der 5-HT-Gehalt des Rattengehirns spektrofluorometrisch bestimmt. Außerdem wurde die MAO-Aktivität von Hirnhomogenaten nach Alkylphosphatvergiftung in vitro und in vivo manometrisch gemessen. Es ergaben sich keine signifikanten Unterschiede gegenüber den Kontrolltieren.

Nach diesen Ergebnissen ist bei der Alkylphosphatvergiftung eine Änderung des 5-HT-Stoffwechsels im Gehirn nicht beteiligt.

Summary

The 5-HT content of the brain of rats being intoxicated with organophosphates was determined fluorometrically. The MAO activity was measured manometrically in brain homogenates after in vitro and in vivo poisoning with organophosphates. No significant differences to control animals were found.

These results suggest that the organophosphate intoxication has no effect on the 5-HT metabolism of the brain.

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Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Universität Göttingen, Germany

    U. Schwabe, D. Heye, H. J. Hildebrandt & T. Hukuhara

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  1. U. Schwabe
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  2. D. Heye
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  3. H. J. Hildebrandt
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  4. T. Hukuhara
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Assistent am Department of Pharmacology, University of Tokyo, z. Z. Forschungsstipendiat der Schering A G.

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Schwabe, U., Heye, D., Hildebrandt, H.J. et al. Alkylphosphatvergiftung und 5-Hydroxytryptamin-Stoffwechsel des Zentralnervensystems. Naunyn - Schmiedebergs Arch 241, 254–259 (1961). https://doi.org/10.1007/BF00246591

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  • DOI: https://doi.org/10.1007/BF00246591

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