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Elektrophysiologische Messungen zur Strophanthinwirkung am Herzmuskel

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Summary

1. The action potential of the papillary muscle is prolonged in the first minutes of Strophanthin application, later it is shortened: ‘plateau loss’. The force of contraction increases throughout the experiment.

2. The Strophanthin intoxication of the Purkinje fibre is characterized by the appearance of extrasystoles and a higher rate of slow diastolic depolarisations.

3. The membrane resistance increases (up to 200%) with Strophanthin, but in extreme intoxication it is reduced.

4. In the presence of Strophanthin the rate of rise of the action potential is reduced.

5. The results of 3. and 4. suggest, that Strophanthin reduces the potassium and sodium permeability of the cardiac muscle fibre. This agrees with direct measurements on erythrocytes and sceletal muscle fibres.

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Authors and Affiliations

  1. Aus dem Physiologischen Institut der Universität Heidelberg, Germany

    J. Dudel & W. Trautwein

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  1. J. Dudel
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  2. W. Trautwein
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Mit 7 Textabbildungen

Ausgeführt mit Hilfe der Rockefeller Foundation und der Deutschen Forschungsgemeinschaft.

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Dudel, J., Trautwein, W. Elektrophysiologische Messungen zur Strophanthinwirkung am Herzmuskel. Naunyn - Schmiedebergs Arch 232, 393–407 (1957). https://doi.org/10.1007/BF00246356

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  • DOI: https://doi.org/10.1007/BF00246356

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