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Facile synthesis of L-Dopa esters by the combined use of tyrosinase and α-chymotrypsin

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Summary

A novel method for the preparative scale synthesis of L-Dopa esters using tyrosinase-catalysed ortho-hydroxylation and proteinase-catalysed transesterification is described. Several L-Dopa esters have been prepared by the combined use of these two enzymes and fully characterised.

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Authors and Affiliations

  1. Department of Biotechnology & Enzymology, AFRC Institute of Food Research, Earley Gate, Whiteknights Road, RG6 2EF, Reading, UK

    Ghulam Ahmed & Evgeny N Vulfson

Authors
  1. Ghulam Ahmed
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  2. Evgeny N Vulfson
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Ahmed, G., Vulfson, E.N. Facile synthesis of L-Dopa esters by the combined use of tyrosinase and α-chymotrypsin. Biotechnol Lett 16, 367–372 (1994). https://doi.org/10.1007/BF00245053

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