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Regulation of calcium handling by rat parotid acinar cells

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Summary

Salivary gland fluid secretion following neurotransmitter stimulation is Ca2+-dependent. We have studied the control of cellular Ca2+ following secretory stimuli in rat parotid gland acinar cells. After muscarinic-cholinergic receptor activation, cytosolic Ca2+ is elevated 4–5 fold, due to both intracellular Ca2+ pool mobilization and extracellular Ca2+ entry. Fluid movement ensues due to the Ca2+-activated enhancement of membrane permeability to K+ and Cl−. Basal cytosolic Ca2+ levels are tightly controlled at ∼150–200 nM through the action of high affinity and high capacity ATP-dependent Ca2+ transporters in the basolateral and endoplasmic reticulum membranes. Activity of these Ca2+ transporters can be modulated to facilitate rapid responsiveness and a sustained fluid secretory response necessary for alimentary function.

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Authors and Affiliations

  1. Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Building 10, Room 1A-05, 20892, Bethesda, Maryland, USA

    Bruce J. Baum & Indu S. Ambudkar

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  1. Bruce J. Baum
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  2. Indu S. Ambudkar
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Baum, B.J., Ambudkar, I.S. Regulation of calcium handling by rat parotid acinar cells. Mol Cell Biochem 82, 67–73 (1988). https://doi.org/10.1007/BF00242518

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