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Human α2macroglobulin

Primary amines and the molecular mechanisms of endoprotease inhibition and receptor-mediated endocytosis

  • Transglutaminase
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Summary

Human α2macroglobulin combines two unique features: the non-active site directed inhibition of virtually all endoproteases and the selective clearance of α2M-endoprotease complexes by receptor-mediated endocytosis. To study the molecular details of the mechanisms involved, primary amines were found to be worthwhile probes at three specific levels: the inactivation of native α2M, the derivatization by factor XIII and the cellular process of receptor-recycling. In this paper published data are supplemented with recently obtained evidence to discuss and speculate on the possible action or involvement of transglutaminase activities, indicated by the effects of the primary amines.

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Authors and Affiliations

  1. Division of Human Genetics, Department of Human Biology, University of Leuven, Minderbroedersstraat 12, B-3000, Leuven, Belgium

    F. van Leuven

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  1. F. van Leuven
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van Leuven, F. Human α2macroglobulin. Mol Cell Biochem 58, 121–128 (1984). https://doi.org/10.1007/BF00240611

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  • DOI: https://doi.org/10.1007/BF00240611

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