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Trans glutaminase-mediated cross-linking in mammalian epidermis

  • Transglutaminase
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Summary

The ε-(γ-glutamyl)lysine isopeptide bond has been identified in certain structural proteins of the hair fibre and the epidermis. The major cross-linked proteins are not keratins and generally have little or no cysteine, but have a high glutamic acid/ glutamine residue content. In the hair fibre the cross-link appears in the citrulline-containing proteins of the medulla and the inner root sheath of the follicle. In the epidermis the cross-linked proteins are involved in the formation of the cornified envelope of the stratum corneum cells. In both cases, the cross-linked proteins contribute the characteristic property of chemical resistance to their b biological structures.

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Authors and Affiliations

  1. Department of Biochemistry, University of Adelaide, 5001, Adelaide, South Australia, Australia

    Joseph A. Rothnagel & George E. Rogers

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  1. Joseph A. Rothnagel
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  2. George E. Rogers
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Rothnagel, J.A., Rogers, G.E. Trans glutaminase-mediated cross-linking in mammalian epidermis. Mol Cell Biochem 58, 113–119 (1984). https://doi.org/10.1007/BF00240610

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  • DOI: https://doi.org/10.1007/BF00240610

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