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Specific effect of zinc ions on DNA polymerase activity of avian myeloblastosis virus

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Summary

The effect of selected cations on DNA synthesis by DNA-polymerase of avian myeloblastosis virus (AMV) was studied. Zinc ions at low concentration (0.2 mm) in the assay system enhanced the activity about 2 × fold and at higher concentration (2.0 mm) inhibited the activity completely. In contrast, addition of lithium and potassium salts produced inhibitory effects in this ionic concentration range. Replacement of K+ ion had an inhibitory effect on the activity.

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Author notes

  1. Prabhudas R. Palan

    Present address: Dept. of Gynecology and Obstetrics, Albert Einstein College of Medicine, 10461, Bronx, New York

Authors and Affiliations

  1. Department of Chemistry, Queens College of the C U.N. Y. Flushing, 11367, New York

    Prabhudas R. Palan & Maxwell L. Eidinoff

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  1. Prabhudas R. Palan
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  2. Maxwell L. Eidinoff
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Palan, P.R., Eidinoff, M.L. Specific effect of zinc ions on DNA polymerase activity of avian myeloblastosis virus. Mol Cell Biochem 21, 67–69 (1978). https://doi.org/10.1007/BF00240277

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  • DOI: https://doi.org/10.1007/BF00240277

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