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Galactolipid fatty acids in brain of pyridoxine-deficient young rats

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Summary

The non-hydroxy fatty acids of the galactolipid fraction of brain lipids of pyridoxine-deficient rats have been analyzed. The results suggest an impairment in the pathway for the synthesis of very long chain fatty acids in the brain of pyridoxine-deficient rats.

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References

  • Aeberhard, E., Grippo, J., Menkes, J.H.: Fatty acid synthesis in the developing brain. Pediat. Res. 3, 590–596 (1969)

    Google Scholar 

  • Bauman, N.A., Bourre, J.N., Jacque, C.M., Harpin, M.L.: Lipid composition of quaking mouse myelin: comparison with normal mouse myelin in the adult and during development. J. Neurochem. 20, 753–759 (1973)

    Google Scholar 

  • Bourre, J.M., Pollet, S.A., Daudu, O.L., Bauman, N.A.: Evolution in mouse brain microsomes of lipid and their constituents during myelination. Brain Res. 51, 225–239 (1973)

    Google Scholar 

  • Braun, P.E., Brady, R.N., Snell, E.E.: Biosynthesis of sphingolipid bases via α keto intermediates. Fed. Proc. 27, 458 (1968)

    Google Scholar 

  • Carey, E.M., Cantrill, R.C.: The relationship between fatty acid activation and elongation in rabbit brain microsomes. J. Neurochem. 24, 807–809 (1975)

    Google Scholar 

  • Dakshinamurti, K., Stephens, M.C.: Pyridoxine deficiency in the neonate rat. J. Neurochem. 16, 1515–1522 (1969)

    Google Scholar 

  • Dakshinamurti, K., Stephens, M.C.: Myelin lipids in pyridoxine deficiency. III. Int. Meet. Int. Soc. Neurochem. Budapest (Abst.) 347 (1971)

  • Dakshinamurti, K., Stephens, M.C., Mokashi, S.: Cerebral fatty acids in pyridoxine deficient young rats. IV. Int. Meet. Int. Soc. Neurochem. Tokyo (Abst.) 347 (1973)

  • Gerstl, B., Malamud, N., Eng, L.F., Hayman, R.B.: Lipid alterations in human brain in phenylketonuria. Neurology 17, 51–57 (1967)

    Google Scholar 

  • Goldberg, L, Shecter, I., Bloch, K.: Fatty acyl coenzyme A elongation in brain of normal and quaking mice. Science 182, 497–499 (1973)

    Google Scholar 

  • Joseph, K.C., Druse, M.J., Neel, L.R., Hogen, E.L.: Fatty acid composition of cerebrosides, sulfatides and ceramides in murine leucodystrophy: The quaking mutant. J. Neurochem. 19, 307–312 (1972)

    Google Scholar 

  • Kishimoto, Y., Radin, N.S.: Metabolism of brain glycolipid fatty acids. Lipids 1, 47–61 (1966)

    Google Scholar 

  • Kurtz, D.J., Kanfer, J.N.: Composition of myelin lipids and synthesis of 3-keto dihydrosphingosine in the vitamin B6 deficient developing rat. J. Neurochem. 20, 963–968 (1973)

    Google Scholar 

  • Morrison, W.R., Smith, L.M.: Preparation of fatty acid methyl esters and dimethyl acetals from lipids with boron fluoride-methanol. J. Lipid Res. 5, 600–608 (1964)

    Google Scholar 

  • Neskovic, N.M., Kostic, D.M.: Quantitative analysis of rat liver phospholipids by a two-step thinlayer chromatographic procedure. J. Chromatog. 35, 297–300 (1968)

    Google Scholar 

  • Nussbaum, J.L., Neskovic, N.M.: The fatty acid composition of phospholipids and glycolipids in Jimpy mouse brain. J. Neurochem. 18, 1529–1543 (1971)

    Google Scholar 

  • Radin, N.: Preparation of lipid extracts. Meth. Enzymol. 14, 245–272 (1969)

    Google Scholar 

  • Siakotos, A.N., Rouser, G.: Analytical separation of non lipid water soluble substances and gangliosides from other lipids by dextran gel column chromatography. J.A.O.C.S. 42, 913–919 (1965)

    Google Scholar 

  • Stephens, M.C., Dakshinamurti, K.: Brain lipids in pyridoxine-deficient young rats. Neurobiology 5, 262–270 (1975)

    Google Scholar 

  • Stephens, M.C., Havlicek, V., Dakshinamurti, K.: Pyridoxine deficiency and the development of CNS in the rat. J. Neurochem. 18, 2407–2416 (1971)

    Google Scholar 

  • Sun, G.Y., Horrocks, L.A.: The metabolism of palmitic acid in the phospholipid, neutral glycerides and galactolipids of mouse brain. J. Neurochem. 16, 181–189 (1969)

    Google Scholar 

  • Williamson, B., Coniglio, J.G.: The effect of pyridoxine deficiency and of caloric restriction on lipids in the developing brain. J. Neurochem. 18, 267–276 (1971)

    Google Scholar 

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Stephens, M.C., Dakshinamurti, K. Galactolipid fatty acids in brain of pyridoxine-deficient young rats. Exp Brain Res 25, 465–468 (1976). https://doi.org/10.1007/BF00239781

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  • DOI: https://doi.org/10.1007/BF00239781

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