Summary
Cynomolgus monkeys with complete bilateral destruction of the medial mamillary nucleus exhibited little, if any, deficit in object recognition, although they did show evidence of impairment in spatial memory. The pattern of effects thus resembled that found previously after either hippocampal ablations or transections of the fornix and suggests that, like such damage, mamillary-body damage alone is insufficient to produce the global amnesia attributed to it in clinical cases.
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References
Aggleton JP, Mishkin M (1983a) Visual recognition impairment following medial thalamic lesions in monkeys. Neuropsychologia 21: 189–197
Aggleton JP, Mishkin M (1983b) Memory impairments following restricted medial thalamic lesions in monkeys. Exp Brain Res 52: 199–209
Aggleton JP, Passingham RE (1981) Stereotaxic surgery under X-ray guidance in the rhesus monkey, with special reference to the amygdala. Exp Brain Res 44: 271–276
Angerlergues R (1969) Memory disorders in neurological disease. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, Vol 3. American Elsevier, New York, pp 268–292
Bachevalier J, Parkinson JK, Mishkin M (1984) Visual recognition in monkeys: effects of separate vs. combined transections of amygdalofugal pathways and fornix. Exp Brain Res 57: 554–561
Brierley JB (1977) Neuropathology of amnesic states. In: Whitty CWM, Zangwill OL (eds) Amnesia. Butterworths, London, pp 199–223
Delay J, Brion S (1969) Le syndrome de Korsakoff. Masson and Cie, Paris
Gaffan D (1974) Recognition impaired and association intact in the memory of monkeys after transection of the fornix. J Comp Physiol Psychol 86: 1100–1109
Holmes EJ, Butters N, Jacobson S, Stein BM (1983a) An examination of mammillary-body lesions on reversal learning sets in monkeys. Physiol Psychol 11: 159–165
Holmes EJ, Jacobson S, Stein BM, Butters N (1983b) Ablations of the mammillary nuclei in monkeys: effects on postoperative memory. Exp Neurol 81: 97–113
Jones B, Mishkin M (1972) Limbic lesions and the problem of stimulus-reinforcement associations. Exp Neurol 36: 362–377
Mahut H (1971) Spatial and object reversal learning in monkeys with partial temporal lobe ablations. Neuropsychologia 9: 409–424
Mahut H (1972) A selective spatial deficit in monkeys after transection of the fornix. Neuropsychologia 10: 65–74
Mahut H (1973) A non-modality specific impairment in spatial learning after fornix lesions in monkeys. Neuropsychologia 11: 255–269
Mahut H, Zola-Morgan S, Moss M (1982) Hippocampal resections impair associative learning and recognition memory in the monkey. J Neurosci 2: 1214–1229
Mair WGP, Warrington EK, Weiskrantz L (1979) Memory disorder in Korsakoffs psychosis. A neuropathlogical and neuropsychological investigation of two cases. Brain 102: 749–783
Malamud N, Skillicorn SA (1956) Relationship between the Wernicke and Korsakoff syndrome: a clinicopathologic study of seventy cases. AMA Arch Neurol Psychiat 76: 585–596
McEntee WJ, Biber MP, Perl DP, Benson DF (1976) Diencephalic amnesia: a reappraisal. J Neurol Neurosurg Psychiat 39: 436–441
Mishkin M (1978) Memory in monkeys severely impaired by combined but not by separate removals of the amygdala and hippocampus. Nature 273: 297–298
Mishkin M, Spiegler BJ, Saunders RC, Malamut BL (1982) An animal model of global amnesia. In: Corkin S, Davis KL, Crowdon JH, Usdin E, Wurtman RJ (eds) Alzheimers disease: a report of progress in research. Raven Press, New York, pp 235–247
Murray EA, Mishkin M (1983) A further examination of the medial temporal-lobe structures involved in recognition memory in the monkey. Soc Neurosci Abstr 9: 27
Rigges HE, Boles RS (1944) Wernicke's encephalopathy: clinical and pathological studies of 42 cases. Q J Stud Alcohol 5: 361–370
Saunders RC (1983) Impairment in recognition memory after mamillary body lesions in monkeys. Soc Neurosci Abstr 9: 28
Veazey RB, Amaral DG (1982) The morphology and connections of the posterior hypothalamus in the cynomolgus monkey (Macaca fascicularis). I. Cytoarchitectonic organization. J Comp Neurol 207: 114–134
Victor M, Adams RD, Collins GH (1971) The Wernicke-Korsakoff syndrome. Blackwell, Oxford
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Aggleton, J.P., Mishkin, M. Mamillary-body lesions and visual recognition in monkeys. Exp Brain Res 58, 190–197 (1985). https://doi.org/10.1007/BF00238967
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DOI: https://doi.org/10.1007/BF00238967