Summary
Electromyograms have been recorded from the human tibialis anterior muscle during voluntary contraction. The accessibility of the nerve to this muscle (common peroneal) has permitted a comparison of reflex responses to low threshold electrical stimulation of the nerve with those to stretch of the muscle itself. Nerve stimulation elicited a reflex at monosynaptic latency (V1 at 28–29 ms) and a second response (V2 at 50–52 ms). A tendon tap induced two responses (m1 at 29 ms and M2 at 50 ms). The responses to a ‘ramp’ stretch were similar. The homology of V1 with M1, and of V2 with M2 is discussed. V2 and M2 probably correspond to the ‘transcortical’ reflexes described from other muscles.
Neither V1 V2, M1 nor M2 were influenced by anaesthesia of the foot. m1 and M2 were both reduced in amplitude by a selective γ-efferent block produced by local anaesthetic in the common peroneal nerve. It is concluded, that muscle spindles are the receptors predominantly responsible for M2 (‘transcortical’) responses.
The amplitudes of M1 and M2, but not V1 and V2 were augmented by prior instruction to ‘resist’ the stimulus. This is interpreted as evidence for voluntary modulation of γ-efferent activity at a constant force of contraction.
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Adam, J., Marsden, C.D., Merton, P.A., Morton, H.B.: The effect of lesions in the internal capsule and the sensorimotor cortex on servo action in the human thumb. J. Physiol. (Lond.) 254, 27–28P (1975)
Allum, J.H.J.: Responses to load disturbances in human shoulder muscles: the hypothesis that one component is a pulse test information signal. Exp. Brain Res. 22, 307–326 (1975)
Ashworth, B., Grimby, L., Kugelberg, E.: Comparison of voluntary and reflex activation of motor units. J. Neurol. Neurosurg. Psychiat. 30, 91–98 (1967)
Burke, D., Andrews, C., Ashby, P.: Autogenic effects of static muscle stretch in spastic man. Arch. Neurol. (Chic.) 25, 367–372 (1971)
Burke, D., Hagbarth., K.-E., Lofstedt, L., Wallin, B.G.: The responses of human muscle spindle endings to vibration during isometric contraction. J. Physiol. (Lond.) 261, 695–711 (1976)
Conrad, D., Aschoff, J.C.: Effects of voluntary isometric and isotonic activity on late transcortical reflex components in normal subjects and hemiparetic patients. Electroenceph. clin. Neurophysiol. 42, 107–116 (1977)
Dawson, G.D., Merton, P.A.: ‘Recurrent’ discharges from motoneurones, pp. 221–222. XX. Congr. Int. Physiol., Bruxelles, Abstr. Comm. 1956
Deschuytere, J., Rosselle, N.: Identification of certain EMG patterns of the spinal cord reflexive activity in man. Electrophysiological study of discharges from spinal origin in the anterolateral muscles of the leg in normal adults. Electromyography 11, 331–363 (1971)
Desmedt, J.E. ed.: New developments in electromyography and clinical neurophysiology, Vol. 3, pp. 773–780. Basel: Karger 1973
Eccles, J.C., Eccles, R.M., Lundberg, A.: The convergence of monosynaptic excitatory afferents on to many different species of alpha motoneurones. J. Physiol. (Lond.) 137, 22–50 (1957)
Evarts, E.V., Granit, R.: Relations of reflexes and intended movements. Progr. Brain Res. 44, 1–10 (1976)
Evarts, E.V., Tanji, J.: Gating of motor cortex reflexes by prior instruction. Brain Res. 71, 479–494 (1974)
Feinstein, B., Lindegaard, B., Nyman, E., Wohlfart, G.: Morphologic studies of motor units in normal human muscles. Acta anat. (Basel) 23, 127–142 (1955)
Gottlieb, G.L., Agarwal, G.C.: The role of the myotatic reflex in the voluntary control of movements. Brain Res. 40, 139–143 (1972)
Gottlieb, G.L., Agarwal, G.C.: Extinction of the Hoffman reflex by antidromic conduction. Electroenceph. clin. Neurophysiol. 41, 19–24 (1976)
Hagbarth, K.E.: Spinal withdrawal reflexes in the human lower limbs. J. Neurol. Neurosurg. Psychiat. 23, 222–237 (1960)
Hagbarth, K.E.: EMG studies of stretch reflexes in man. Electroenceph. clin. Neurophysiol. Suppl. 25, 74–79 (1967)
Hammond, P.H.: An experimental study of servo action in human muscular control, pp. 190–199. Proc. 3rd. int. Conf. med. Electr. 1960
Hannerz, J.: Discharge properties of motor units in relation to recruitment order in voluntary contraction. Acta physiol. scand. 91, 374–384 (1974)
Herman, R.: Electromyographic evidence of some control factors involved in the acquisition of skilled performance. Amer. J. phys. Med. 49, 177–191 (1970)
Hohman, T.C., Goodgold, J.: A study of abnormal reflex patterns in spasticity. Amer. J. phys. Med. 40, 52–55 (1960)
Iles, J.F.: Reflex responses in human pretibial muscles. J. Physiol. (Lond.) 260, 54–55P (1976)
Kernell, D.: Effects of synapses on dendrites and soma on the repetitive impulse firing of a compartmental neuron model. Brain Res. 35, 551–555 (1971)
Kolb, H.: Morphologische und funktionelle Analyse des M. tibialis anterior. Z. Anat. Entwickl.-Gesch. 106, 770–781 (1937)
Lamarre, Y., Lund, J.P.: Load compensation in human masseter muscles. J. Physiol. (Lond.) 253, 21–35 (1975)
Lee, R.G., Tatton, W.G.: Motor responses to sudden limb displacements in primates with specific CNS lesions and in human patients with motor system disorders. Canad. J. Neurol. Sci. 2, 285–293 (1975)
Lloyd, D.P.C.: Stimulation of peripheral nerve terminations by active muscle. J. Neurophysiol. 5, 153–165 (1942)
MacLennan, C.R.: The behaviour of receptors of extramuscular and muscular origin with afferent fibres contributing to the group I and group II of the cat tibialis anterior muscle nerve. J. Physiol. (Lond.) 222, 90–91P (1972)
Magladery, J.W.: Some observations on spinal reflexes in man. Pflügers Arch. ges. Physiol. 261, 302–321 (1955)
Marsden, C.D., Merton, P.A., Morton, H.B.: Is the human stretch reflex cortical rather than spinal? Lancet I, 759–761 (1973)
Marsden, C.D., Merton, P.A., Morton, H.B.: Servo action in the human thumb. J. Physiol. (Lond.) 257, 1–44 (1976a)
Marsden, C.D., Merton, P.A., Morton, H.B.: Stretch reflexes and servo action in a variety of human muscles. J. Physiol. (Lond.) 259, 531–560 (1976b)
Marsden, C.D., Merton, P.A., Morton, H.B.: The sensory mechanism of servo action in human muscle. J. Physiol. (Lond.) 265, 521–536 (1977)
Matthews, P.B.C., Rushworth, G.: The selective effect of procaine on the stretch reflex and tendon jerk of soleus muscle when applied to its nerve. J. Physiol. (Lond.) 135, 245–262 (1957a)
Matthews, P.B.C., Rushworth, G.: The relative sensitivity of muscle nerve fibres to procaine. J. Physiol. (Lond.) 135, 263–269 (1957b)
Matthews, P.B.C., Rushworth, G.: The discharge from muscle spindles as an indicator of γ-efferent paralysis by procaine. J. Physiol. (Lond.) 140, 421–426 (1958)
Mayer, R.F., Mawdsley, C.: Studies in man and the cat of the significance of the H wave. J. Neurol. Neurosurg. Psychiat. 28, 201–211 (1965)
Meier-Ewart, K., Humme, U., Dahm, H.: New evidence favouring long loop reflexes in man. Arch. Psychiat. Nervenkr. 215, 121–128 (1972)
Melvill-Jones, G.M., Watt, D.G.D.: Observations on the control of stepping and hopping movements in man. J. Physiol. (Lond.) 219, 709–727 (1971)
Milner-Brown, H.S., Stein, R.B., Lee, R.G.: Synchronization of human motor units: possible roles of exercise and supraspinal reflexes. Electroenceph. clin. Neurophysiol. 38, 245–254 (1975)
Nashner, L.M.: Adapting reflexes controlling the human posture. Exp. Brain Res. 26, 59–72 (1976)
Paillard, J.: Réflèxes et régulations d'origine proprioceptive chez l'homme. Paris: Librairie Arnette 1955
Rushworth, G.: Spasticity and rigidity: an experimental study and review. J. Neurol. Neurosurg. Psychiat. 23, 99–118 (1960)
Shahani, B.T.: Flexor reflex afferent nerve fibres in man. J. Neurol. Neurosurg. Psychiat. 33, 786–791 (1970)
Shimamura, M., Mori, S., Matsushima, S., Fujimori, B.: On the spino-bulbo-spinal reflex in dogs, monkeys and man. Jap. J. Physiol. 14, 411–421 (1964)
Stephens, J.A., Usherwood, T.P., Garnett, R.: Technique for studying synaptic connections of single motoneurons in man. Nature (Lond.) 263, 343–344 (1976)
Tanaka, R.: Reciprocal la inhibition during voluntary movements in man. Exp. Brain Res. 21, 529–540 (1974)
Tanji, J.: Selective activation of neurons in cortical area 3a associated with accurate maintenance of limb position. Brain Res. 115, 328–332 (1976)
Tatton, W.G., Lee, R.G.: Evidence for abnormal long loop reflexes in rigid Parkinsonian patients. Brain Res. 100, 671–676 (1975)
Tatton, W.G., Forner, S.D., Gerstein, G.L., Chambers, W.W., Liu, C.N.: The effect of postcentral cortical lesions on motor responses to sudden upper limb displacements in monkeys. Brain Res. 96, 108–113 (1975)
Teasdall, R.D., Park, A.M., Porter, W.E., Magladery, J.W.: Electrophysiological studies of nerve and reflex activity in normal man. VI. Excitation and inhibition of two neurone reflexes by impulses in other nerves. Johns Hopk. Hosp. Bull. 88, 538–548 (1951)
Teasdall, R.D., Park, A.M., Languth, H.W., Magladery, J.W.: Electrophysiological studies of reflex activity in patients with lesions of the nervous system. II. Disclosure of normally suppressed monosynaptic discharge of spinal motoneurones by lesions of lower brain stem and spinal cord. Johns Hopk. Hosp. Bull. 91, 245–256 (1952)
Upton, A.R.M., McComas, A.J., Sica, R.E.P.: Potentiation of ‘late’ responses evoked in muscles during effort. J. Neurol. Neurosurg. Psychiat. 34, 699–711 (1971)
Vallbo, Å.B.: Human muscle spindle discharge during isometric voluntary contractions. Amplitude relations between spindle frequency and torque. Acta physiol. scand. 90, 319–336 (1974)
Vilis, T., Cooke, J.D.: Modulation of the functional stretch reflex by the segmental reflex pathway. Exp. Brain Res. 25, 247–254 (1976)
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Iles, J.F. Responses in human pretibial muscles to sudden stretch and to nerve stimulation. Exp Brain Res 30, 451–470 (1977). https://doi.org/10.1007/BF00237637
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DOI: https://doi.org/10.1007/BF00237637