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Time of origin and distribution of a new cell type in the rat cerebellar cortex

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Summary

A new cell type was identified in the granular layer of the rat cerebellum. It has a lightly staining nucleus with a nucleolus, it is spherical in shape and is larger than granule cells and smaller than Golgi cells. These pale cells are preferentially concentrated in the nodulus, the ventral uvula, the lingula, the flocculus, and parts of the paraflocculus. According to autoradiographic (3H-thymidine) evidence, over 60% of these pale cells are formed on embryonic days 19 and 20, and their production comes to an end soon after birth, prior to the differentiation of granule cells. The possible relation of pale cells to vestibular afferents of the cerebellar cortex is discussed.

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References

  • Altman, J.: The use of fine-resolution autoradiography in neurological and psychobiological research. In: Response of the Nervous System to Ionizing Radiation (eds. T.J. Haley and R.S. Snider), pp. 336–359. Boston: Little, Brown 1964

    Google Scholar 

  • Altman, J.: Autoradiographic and histological studies of postnatal neurogenesis. II. J. comp. Neurol. 128, 431–474 (1966)

    Google Scholar 

  • Altman, J.: Autoradiographic and histological studies of postnatal neurogenesis. III. J. comp. Neurol. 136, 269–294 (1969)

    Google Scholar 

  • Altman, J., Das, G.D.: Autoradiographic and histological studies of postnatal neurogenesis. I. J. Comp. Neurol. 126, 337–390 (1966)

    Google Scholar 

  • Bayer, S.A., Altman, J.: Hippocampal development in the rat: Cytogenesis and morphogenesis examined with autoradiography and low-level X-irradiation. J. comp. Neurol. 158, 55–80 (1974)

    Google Scholar 

  • Brodal, A.: Vestibulocerebellar input in the cat: anatomy. Progr. Brain Res. 37, 315–327 (1972)

    Google Scholar 

  • Brodal, A., Drabløs, P.A.: Two types of mossy fiber terminals in the cerebellum and their regional distribution. J. Comp. Neurol. 121, 173–187 (1963)

    Google Scholar 

  • Brodal, A., Høivik, B.: Site and mode of termination of primary vestibulo-cerebellar fibers in the cat. An experimental study with silver impregnation methods. Arch. ital. Biol. 102, 1–21 (1964)

    Google Scholar 

  • Carpenter, M.B., Stein, B.M., Peter, P.: Primary Vestibulocerebellar fibers in the monkey: Distribution of fibers arising from distinctive cell groups of the vestibular ganglia. Amer. J. Anat. 135, 221–250 (1972)

    Google Scholar 

  • Das, G.D., Nornes, H.O.: Neurogenesis in the cerebellum of the rat: an autoradiographic study. Z. Anat. Entwickl.-Gesch. 138, 155–165 (1972)

    Google Scholar 

  • Dow, R.S.: Cerebellar action potentials in response to stimulation of various afferent connections. J. Neurophysiol. 2, 543–555 (1939)

    Google Scholar 

  • Larsell, O.: The morphogenesis and adult pattern of the lobules and fissures of the cerebellum of the white rat. J. Comp. Neurol. 97, 281–356 (1952)

    Google Scholar 

  • Larsell, O.: The Comparative Anatomy and Histology of the Cerebellum from Mysinoids through Birds, pp. 270–273. Minneapolis: Univ. Minnesota Press 1967

    Google Scholar 

  • Llinás, R., Hillman, D.E.: Physiological and morphological organization of the cerebellar circuits in various vertebrates. In: Neurobiology of Cerebellar Evolution and Development (ed. R. Llinás), pp. 43–73. Chicago: Amer. Med. Assoc. 1969

    Google Scholar 

  • Llinás, R., Precht, W., Clarke, M.: Cerebellar Purkinje cell responses to physiological stimulation of the vestibular system in the frog. Exp. Brain Res. 13, 408–431 (1971)

    Google Scholar 

  • Palay, S.L., Chan-Palay, V.: Cerebellar Cortex: Cytology and Organization, pp. 121–123. Berlin: Springer 1974

    Google Scholar 

  • Precht, W., Llinás, R.: Functional organization of the vestibular afferents to the cerebellar cortex of frog and cat. Exp. Brain Res. 9, 30–52 (1969)

    Google Scholar 

  • Ramón y Cajal, S.: Histologie du Système Nerveux de l'Homme des Vertébrés. Vol. 2, pp. 1–54. Paris: Maloine 1911

    Google Scholar 

  • Schultze, B., Nowak, B., Maurer, W.: Cycle times of the neural epithelial cells of various types of neuron in the rat. An autoradiographic study. J. comp. Neurol. 158, 207–218 (1974)

    Google Scholar 

  • Shinoda, Y., Yoshida, K.: Neural pathways from the vestibular labyrinths to the flocculus in the cat. Exp. Brain Res. 22, 97–111 (1975)

    Google Scholar 

  • Wilson, V.J., Anderson, J.A., Felix, D.: Semicircular canal input to pigeon vestibulocerebellum. Brain Res. 45, 230–235 (1972)

    Google Scholar 

  • Wilson, V.J., Anderson, J.A., Felix, D.: Unit and field potential activity evoked in the pigeon vestibulocerebellum by stimulation of individual semicircular canals. Exp. Brain Res. 19, 142–157 (1974)

    Google Scholar 

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Altman, J., Bayer, S.A. Time of origin and distribution of a new cell type in the rat cerebellar cortex. Exp Brain Res 29, 265–274 (1977). https://doi.org/10.1007/BF00237046

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