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The activated hypothalamic magnocellular neurosecretory system and the one neuron -one neurohypophysial hormone concept

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Summary

The activated hypothalamic magnocellular neurosecretory system of the rat was studied in tissue sections, double stained with the unlabeled antibody peroxidase-antiperoxidase complex (PAP) technique. The results indicate that in animals with an activated hypothalamic magnocellular neuroendocrine system, as well as in normal animals, vasopressin and oxytocin are exclusively synthesized in separate vasopressinergic and oxytocinergic neurons.

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References

  • Boudier, J.-A., Detieux, Y., Dutillet, B., Luciani, J.: Effets de la colchicine sur le noyau supra-optique du Rat réhydraté après privation d'eau. C.R. Acad. Sc. Paris, 274, 1051–1054 (1972)

    Google Scholar 

  • Brimble, M.J., Dyball, R.E.J., Forsling, M.L.: Oxytocin release following osmotic activation of oxytocin neurones in the paraventricular and supraoptic nuclei. J. Physiol. 278, 69–78 (1978)

    Google Scholar 

  • Dierickx, K., Vandesande, F., Goossens, N.: The one neuron-one neurohypophysial hormone hypothesis and the hypothalamic magnocellular neurosecretory system of the vertebrates. In: Coll. Int. du C.N.R.S. N∘ 280 (J.-D. Vincent and C. Kordon, eds.), pp. 391–398. Paris: Edit. Centre Nat. Rech. Sci. 1978

    Google Scholar 

  • George, J.M.: Vasopressin and oxytocin are depleted from rat hypothalamic nuclei after oral hypertonic saline. Science, 193, 146–148 (1976)

    Google Scholar 

  • Jones, C.W., Pickering, B.T.: Comparison of the effects of water deprivation and sodium chloride imbibition on the hormone content of the neurohypophysis of the rat. J. Physiol. 203, 449–458 (1969)

    Google Scholar 

  • Paterson, J.A., Leblond, C.P.: Increased proliferation of neuroglia and endothelial cells in the supraoptic nucleus and hypophysial neural lobe of young rats drinking hypertonic sodium chloride solution. J. Comp. Neurol., 175, 373–390 (1977)

    Google Scholar 

  • Robinson, A.G.: Neurophysins, an aid to understanding the structure and function of the neurohypophysis. In: Frontiers in neuroendocrinology. Vol. 5. (W.F. Ganong and L. Martini, eds.), pp. 35–59. New York: Raven Press 1978

    Google Scholar 

  • Sachs, H.: Neurosecretion. In: Handbook of neurochemistry. (A. Lajtha ed.), pp. 373–428. New York-London: Plenum Press 1970

    Google Scholar 

  • Stutinsky, F.S.: Hypothalamic neurosecretion. In: The hypothalamus. (L. Martini, M. Motta and F. Fraschini, eds.), pp. 45–67. New York-London: Academic Press 1970

    Google Scholar 

  • Vandesande, F.: A critical review of immunocytochemical methods for light microscopy. J. Neurosci. Methods, 1, 3–23 (1979)

    Google Scholar 

  • Vandesande, F., Dierickx, K.: Immunocytochemical demonstration of separate vasotocinergic and mesotocinergic neurons in the amphibian hypothalamic magnocellular neurosecretory system. Cell Tissue Res. 175, 289–296 (1976)

    Google Scholar 

  • Vandesande, F., Dierickx, K., De Mey, J.: The origin of the vasopressinergic and oxytocinergic fibres of the external region of the median eminence of the rat hypophysis. Cell Tissue Res. 180, 443–452 (1977)

    Google Scholar 

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This investigation was supported by a grant from the Belgian Nationaal Fonds voor Geneeskundig Wetenschappelijk Onderzoek

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Vandesande, F., Dierickx, K. The activated hypothalamic magnocellular neurosecretory system and the one neuron -one neurohypophysial hormone concept. Cell Tissue Res. 200, 29–33 (1979). https://doi.org/10.1007/BF00236884

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