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Glutamate and aspartate mimic the afferent transmitter in the cochlea

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Summary

Glutamate (50 mM) and aspartate (50 mM) applied intracochlearly increase the spontaneous activity of ganglion cells of the auditory nerve. This activity may account for the decreased magnitude of the compound action potential observed with these substances in previous studies, and also may be additional evidence that these substances have a role in synaptic transmission between the hair cells and primary auditory afferent nerve cells.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Louisiana State University Medical Center, Kresge Hearing Research Laboratory of the South, Building 164, 1100 Florida Avenue, 70119, New Orleans, LA, USA

    R. P. Bobbin

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  1. R. P. Bobbin
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Bobbin, R.P. Glutamate and aspartate mimic the afferent transmitter in the cochlea. Exp Brain Res 34, 389–393 (1979). https://doi.org/10.1007/BF00235683

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  • DOI: https://doi.org/10.1007/BF00235683

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