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Role of antecedent mumps and reovirus infections on the development of type 1 (insuling-dependent) diabetes

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Abstract

Type 1 diabetes mellitus is thought to derive from organ-specific autoimmune reactions, probably triggered by environmental factors. In view of the possible involvement of mumps virus and reoviruses in the pathogenesis of autoimmune endocrine disease, serum antibody levels to these viruses were measured in newly-diagnosed diabetic patients aged 5 to 25 years and in matched control subjects. Diabetic patients showed a significantly lower prevalence and reduced titers of antibodies to mumps and reoviruses. By contrast, the antibody response to measles virus (a non-diabetogenic agent) was remarkably similar in the two groups. It is suggested that individuals with an impaired humoral response to some viral agents are at increased risk of developing diabetes when exposed to pancreotropic viruses.

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References

  1. AndersenO.O., ChristyM., ArnungK., BuschardA.K., ChristanB., KromannH., NerupJ., PlatzP., RyderL.P., SvejigaardA., Thomsen M. (1977): Viruses and diabetes. In: Diabetes, Proceedings of the IX Congress of the International Diabetes Federation. Edited by J.S. Bajaj; pp. 294–298. Excerpta Medica, Amsterdam.

    Google Scholar 

  2. BodanskyH.J., LittlewoodJ.M., BottazzoG.F., DeanB.M., HamblingM.H. (1984): Which virus causes the initial lesion in type 1 diabetes? - Lancet, 1: 401–402.

    Google Scholar 

  3. Calvet M.A., Aymard M. (1983): Apport du diagnostic sérologique a la connaissance de l'épidémiologie des Reovirus. Résumé de la Reunion de la Societé Francaise de Microbiologie du 3 Février 1983.

  4. CavenderD.E., WagenerD.K., OrchardT.J., LaPorteR.E., BeckerD.J., KullerL.H. (1984): Multivariate analysis of the risk of insulin-dependent diabetes mellitus for siblings of insulin-dependent diabetic patients - Am. J. Epidemiol., 120: 315–327.

    Google Scholar 

  5. CraigheadJ.E. (1980): Viral diabetes mellitus in man and experimental animals. - Am. J. Med., 70: 127–135.

    Google Scholar 

  6. EnglandW.L., RobertsS.D. (1981): Immunization to prevent insulin~dependent diabetes mellitus?- Ann. Int. Med., 94: 395–400.

    Google Scholar 

  7. EpsteinR.L., FinbergR., PowersM.L., WeinerH.L. (1984): Interaction of Reovirus with cell surface receptors. IV. The Reovirus type 3 receptor is expressed predominantly on murine Lyt-2;3+ and human T8+ cells. - J. Immunol., 133: 1614–1617.

    Google Scholar 

  8. EvansA.S. (1984): Viral infections of humans. Epidemiology and control. 2nd edition. Plenum Publishing Co., New York.

    Google Scholar 

  9. GambleD.R. (1980): The epidemiology of insulin-dependent diabetes with particular reference to the relationship of virus infection to its etiology.- Epidemiol. Rev., 2: 49–70.

    CAS  PubMed  Google Scholar 

  10. GambleD.R. (1980): Relation of antecedent illness to development of diabetes in children. - Br. Med. J., 2: 99–101.

    Google Scholar 

  11. GambleD.R., KinsleyM.L., FitzgeraldM.G., BoltonR., TaylorK.W. (1969): Viral antibodies in diabetes mellitus. - Br. Med. J., 3: 627–630.

    Google Scholar 

  12. Gundersen E. (1927): Is diabetes of infectious origin?- J. Infect. Dis., 4: 197–202.

    Google Scholar 

  13. HaspelM.V., OnoderaT., PrabhakarB.S., HoritaM., SuzukiH., NotkinsA.L. (1983): Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues. - Science, 220: 304–306.

    Google Scholar 

  14. HaspelM.V., OnoderaT., PrabhakarB.S., Mc ClintockP.R., EssaniK., RayU.R., YagihashiS., NotkinsA.L. (1983): Multiple organ-reactive monoclonal autoantibodies. - Nature, 303: 73–76.

    Google Scholar 

  15. HayesE.C., LeeP.W.K., MillerS.E., JoklikW.K. (1981): The interaction of a series of hybridoma IgGs with Reovirus particles. - Virology, 108: 147–155.

    Google Scholar 

  16. HelmkeK., OttenA., WillemsW. (1980): Islet-cell antibodies in children with mumps infection. -Lancet 2: 401–402.

    Google Scholar 

  17. HenleG., HenleW. (1976): Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. - Int. J. Cancer, 17: 1–7.

    Google Scholar 

  18. KingR.C. (1962): Mumps followed by diabetes. -Lancet, 2: 1055.

    Google Scholar 

  19. MarxJ.L. (1984): Diabetes - A possible autoimmune disease. - Science, 225: 1381–1383.

    Google Scholar 

  20. MessaritakisJ., KarabulaC., KattamisC., MatsaniotisN. (1971): Diabetes following mumps in sibs.- Arch. Dis. Child., 46: 561–562.

    Google Scholar 

  21. National Diabetes Data Group (1979): Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. - Diabetes, 28: 1039–1057.

    Google Scholar 

  22. NotkinsA.L. (1979): The causes of diabetes. - Sci. Am., 241: 62–73.

    Google Scholar 

  23. OnoderaT., JensonA.B., YoonJ.W., NotkinsA.L. (1978): Virus-induced diabetes mellitus: Reo-virus infection of pancreatic B cells in mice. - Science, 201: 529–531.

    Google Scholar 

  24. OnoderaT., RayU.R., MelezK.A., SuzukiH., TonioloA., NotkinsA.L. (1982): Virus-induced diabetes mellitus: Autoimmunity and polyendocrine disease prevented by immunosuppression. - Nature, 297: 66–68.

    Google Scholar 

  25. OnoderaT., TonioloA., RayU.R., JensonA.B., KnazekA., NotkinsA.L.. (1981): Virus-induced diabetes mellitus. XX. Polyendocrinopathy and autoimmunity.- J. Exp. Med. 153: 1457–1473.

    Google Scholar 

  26. PalmerJ.P., CooneyM.K., WardR.H., HansenJ.A., BrodskyJ.B., RayC.G., CrossleyJ.R., AsplinC.M., WilliamsR.H. (1982): Reduced Coxsackie antibody titres in type 1 (insulin-dependent) diabetic patients presenting during an outbreak of Coxsackie 133 and 134 infection. - Diabetologia, 22: 426–429.

    Google Scholar 

  27. PrinceG.A., JensonA.B., BillupsL.C., NotkinsA.L. (1978): Infection of human pancreatic beta cell cultures with mumps virus. - Nature, 271: 158–161.

    Google Scholar 

  28. RatzmannK.P., StreseJ., RjasanowskiL, WittS., KeilackerH. (1984): Prevalence of islet cell antibodies (ICA) and islet cell surface antibodies (ICSA) in children and adolescents with antecedent mumps infection. - Clin. Exp. Endocrinol., 83: 199–202.

    Google Scholar 

  29. RayfieldE.J., SetoY. (1981): Viruses. In: Handbook of Diabetes Mellitus. Edited by M. Brownlee; Vol. 1, pp. 95–120. Garland STPM press, New York.

    Google Scholar 

  30. RichensE.R., JonesW.G.(1981): Islet cell antibodies and mumps. - Lancet 1: 507–508.

    Google Scholar 

  31. SchmidtN.J. (1980): Enteroviruses and Reoviruses. In: Manual of Clinical Immunology. Edited by N.R. Rose, H. Friedman; 2nd edition, pp. 672–677. Am. Soc. Microbiol. Washington, D.C..

    Google Scholar 

  32. StanleyN.F. (1977): Diagnosis of Reovirus infections: comparative aspects. In: Comparative Diagnosis of Viral Diseases. Edited by E. Kurstak, C. Kurstak; pp. 385–421. Academic Press, New York.

    Google Scholar 

  33. SultzH.A., HartB.A., ZieleznyM., SchlesingerE.R. (1975): Is mumps virus an aetiological factor in juvenile diabetes mellitus? - J. Pediatr., 86: 654–656.

    Google Scholar 

  34. TardieuM., PowersM.L., HaflesD.A., HansenS.L., WeinerH.L. (1984): Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with Reovirus and demonstration of shared antigenicity between virus and lymphocytes. - Eur. J. Immunol., 14: 561–565.

    Google Scholar 

  35. Toniolo A., Conaldi P.G., Ruschi M.A., Federspil G. (1985): Ridotta risposta anticorpale verso i Reovirus in pazienti con diabete tipo 1 in fase iniziale.- Ig. Mod., in press.

  36. TonioloA., OnoderaT. (1984): Viruses and diabetes. In: Immunology in Diabetes. Edited by D. Andreani, U. Di Mario, K.F. Federlin, L.G. Heding; pp. 71–93. Kimpton Med. Publ., London.

    Google Scholar 

  37. TrioloG., GiardinoE., ZarconeM.R., Giordano C., RinaldiA., BompianiG.D. (1984): Contribution of secretory IgA, polymeric IgA and IgA/secretory component-containing circulating immune complexes to the serum hyper-IgA in diabetes mellitus- Diabetologia, 27: 157–159.

    Google Scholar 

  38. TuokkoH. (1984): Comparison of nonspecific reactivity in indirect and reverse immunoassays for measles and mumps immunoglobulin M antibodies.- J. Clin. Microbiol., 20: 972–976.

    Google Scholar 

  39. VandvikB., NorrbyE., NordalH.J., DegréM. (1977): Oligoclonal measles virus-specific IgA antibodies isolated from sera of patients with subacute sclerosing panencephalitis. - Scand. J. Immunol., 6: 641–648.

    Google Scholar 

  40. VaughanJ.G., CarsonD.A., FoxR.I. (1983): The Epstein-Barr virus and rheumatoid arthritis. - Clin. Exp. Rheumatol. I: 265–272.

    Google Scholar 

  41. YoonJ.W., SelvaggioS., OnoderaT., WheelerJ., JepsonA.B. (1981): Infection of cultured human pancreatic B cells with Reovirus type 3. - Diabetologia, 20: 462–467.

    Google Scholar 

  42. ZierK.S., LeoM.M., SpielmanR.S., BakerL. (1984): Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus. - Diabetes, 33: 552–555.

    Google Scholar 

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Authors and Affiliations

  1. Istituto di Microbiologia, University of Pisa, Pisa

    A. Toniolo, P.G. Conalpi, C. Garzelli & G. Benedettini

  2. Istituto di Clinica Pediatrica, University of Pisa, Pisa

    G. Federico & G. Saggese

  3. Istituto di Semeiotica Afedica, University of Padova, Padova

    R. Vettor & G. Federspil

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  1. A. Toniolo
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  2. P.G. Conalpi
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  3. C. Garzelli
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  4. G. Benedettini
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  5. G. Federico
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  6. G. Saggese
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  7. R. Vettor
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  8. G. Federspil
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Toniolo, A., Conalpi, P., Garzelli, C. et al. Role of antecedent mumps and reovirus infections on the development of type 1 (insuling-dependent) diabetes. Eur J Epidemiol 1, 172–179 (1985). https://doi.org/10.1007/BF00234091

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