Summary
Thalamic neurons projecting to the arm area of the motor cortex were identified by their antidromic response to stimulation of that area in two awake monkeys. Neurons were further identified as receiving inputs from the cerebellar nuclei or the internal segment of the globus pallidus by excitatory or inhibitory response to stimulation of these nuclei. Most (33/34) of the thalamic neurons in the cerebello-thalamo-cortical projection and more than half (12/18) of those in the pallido-thalamocortical projection changed their firing rate on the leverlifting hand movement in the reaction-time task. A considerable number of neurons of both groups (14/23 and 3/10) changed their firing rate prior to the onset of the earliest EMG. These findings agree with the model that activities of pallidal as well as cerebellar nuclear neurons related to motor control are transmitted to the motor cortex through the thalamus.
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References
Crutcher MD, DeLong MR (1984) Single cell studies of the primate putamen. I. Functional organization. Exp Brain Res 53: 233–243
DeLong MR, Crutcher MD, Georgopoulos AP (1985) Primate globus pallidus and subthalamic nucleus: functional organization. J Neurophysiol 53: 530–543
Evarts EV (1974) Precentral and postcentral cortical activity in association with visually triggered movement. J Neurophysiol 37: 373–381
Fetz EE, Cheney PD (1980) Postspike facilitation of forelimb muscle activity by primate corticomotoneuronal cells. J Neurophysiol 44: 751–772
Georgopoulos AP, DeLong MR, Crutcher MD (1983) Relations between parameters of step-tracking movements and single cell discharge in the globus pallidus and subthalamic nucleus of the behaving monkey. J Neurosci 3: 1586–1598
Horne MK, Porter R (1980) The discharges during movement of cells in the ventrolateral thalamus of the conscious monkey. J Physiol (Lond) 304: 349–372
Kim R, Nakano K, Jayaraman A, Carpenter MB (1976) Projections of the globus pallidus and adjacent structures: an autoradiographic study in the monkey. J Comp Neurol 169: 263–290
Macpherson JM, Rasmussen DD, Murphy JT (1980) Activities of neurons in “motor” thalamus during control of limb movement in the primate. J Neurophysiol 44: 11–28
Nambu A, Yoshida S, Jinnai K (1988) Projection on the motor cortex of thalamic neurons with pallidal input in the monkey. Exp Brain Res 71: 658–662
Nambu A, Yoshida S, Jinnai K (1990) Discharge patterns of pallidal neurons with input from various cortical areas during movement in the monkey. Brain Res 519: 183–191
Olszewski J (1952) The thalamus of the Macaca mulatta: an atlas for use with the stereotaxic instrument. S Karger, Basel New York
Schell GR, Strick PL (1984) The origin of thalamic inputs to the arcuate premotor and supplementary motor areas. J Neurosci 4: 539–560
Strick PL (1976) Activity of ventrolateral thalamic neurons during arm movement. J Neurophysiol 39: 1032–1044
Thach WT (1978) Correlation of neural discharge with pattern and force of muscular activity, joint position and direction of intended next movement in motor cortex and cerebellum. J Neurophysiol 41: 654–676
Tsumoto T, Creutzfeldt OD, Legedy CR (1978) Functional organization of corticofugal system from visual cortex to lateral geniculate nucleus in the cat (with an appendix on geniculo-cortical mono-synaptic connections). Exp Brain Res 32: 345–364
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Nambu, A., Yoshida, S. & Jinnai, K. Movement-related activity of thalamic neurons with input from the globus pallidus and projection to the motor cortex in the monkey. Exp Brain Res 84, 279–284 (1991). https://doi.org/10.1007/BF00231447
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DOI: https://doi.org/10.1007/BF00231447