Abstract
It has been suggested that the tunica vasculosa lentis of newborn mice undergoes vasoproliferation after oxygen exposure and might be used as an experimental model for intraocular neovascularization. A scanning electron microscopic technique which provides visualization of the entire hyaloid vascular system was used to study its response in mice exposed to various gas mixtures (70% O2/30% N2, 10% CO2/90% air, 10% CO2/70% O2/20% N2). Marked differences were found between hyaloid regression in gas exposed mice compared to air control mice, but no evidence of neovascularization was found in any group. The data support the possibility that changes in the hyaloid may be the consequence of the hydrostatic coupling which exists between this atrophic, possibly flow-resistant vasculature and the developing retinal vasculature whose blood flow characteristics are significantly altered by exposure to CO2 and O2.
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References
Ashton N (1968) Some aspects of the comparative pathology of oxygen toxicity in the retina. Br J Ophthalmol 52:505–531
Flower RW (1983) A mechanism for oxygen damage to the immature retinal vasculature. In: Lübbers DW, Acker H, Leniger-Follert E, Goldstick TK (eds) Oxygen transport to tissue, Vol. V. Plenum Press, New York, NY, in press
Gloor BP (1973) Zur Entwicklung des Glaskörpers und des Zonula: I. Überblick und chronologischer Ablauf der Glaskörper und Zonulaentwicklung bei Kaninchen und Maus. Graefe's Arch Clin Exp Ophthalmol 186:299–309
Gyllensten LJ, Hellström BE (1954) Experimental approach to the pathogenesis of retrolental fibroplasia: I. Changes of the eye induced by exposure of newborn mice to concentrated oxygen. Acta Paediatr Scand 43:131–148
Hollenberg MJ, Dickson DH (1971) Scanning electron microscopy of the tunica vasculosa lentis of the rat. Can J Ophthalmol 6:301–310
Patz A, Eastham A, Higginbotham DH, Kleh T (1953) Oxygen studies in retrolental fibroplasia: II. The production of the microscopic changes of retrolental fibroplasia in experimental animals. Am J Ophthalmol 36:1511–1522
Patz A (1982) Clinical and experimental studies on retinal neovascularization (XXXIX Edward Jackson Memorial Lecture). Am J Ophthalmol 94:715–743
Pollock WBI (1923) Case of pseudo-glioma due to persistence and thickening of the posterior fibro-vascular sheath of the lens. Trans Ophthalmol Soc UK 43:263–271
Reese AB, Payne F (1946) Persistence and hyperplasia of the primary vitreous (tunica vasculosa lentis or retrolental fibroplasia). Am J Ophthalmol 29:1–19
Szewczyk TS (1952) Retrolental fibroplasia: Etiology and Prophylaxis. Am J Ophthalmol 35:301–311
Terry TL (1942) Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens. I. Preliminary report. Am J Ophthalmol 25:203–204
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This work was supported in part by the Florian Verrey Foundation, Switzerland, and NIH Grant EY-02482
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Bischoff, P.M., Wajer, S.D. & Flower, R.W. Scanning electron microscopic studies of the hyaloid vascular system in newborn mice exposed to O2 and CO2 . Graefe's Arch Clin Exp Ophthalmol 220, 257–263 (1983). https://doi.org/10.1007/BF00231352
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DOI: https://doi.org/10.1007/BF00231352