Skip to main content
SpringerLink
Log in

Nuclear protein kinases

  • Review
  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Summary

Nuclear protein kinases include enzymes that transfer the γ-phosphate of ATP to serine, threonine, lysine or histidine in proteins. Nuclear kinases with a preference for basic proteins are known as histone kinases; those preferring acidic protein substrates are casein kinases. Histone kinases include both cyclic AMP-independent protein kinases and cyclic AMP-dependent protein kinases. The best-characterized cyclic AMP-independent nuclear protein kinase is associated with cell proliferation and is activated (or transported to the nucleus) in G2 phase of the cell cycle. It phosphorylates specific serine and threonine residues in the non globular domains of histone H1 and appears to promote chromosome condensation. The cyclic AMP-dependent protein kinase has unknown nuclear function(s), although it may be translocated from cytoplasm to nucleus in response to specific hormonal stimuli which are also associated with changes in transcriptional activity. There is a massive peak of nuclear cyclic AM P-dependent protein kinase activity in G2 phase of the cell cycle. Nuclear casein kinases are apparently very heterogeneous. Two of these enzymes have been purified to homogeneity. They phosphorylate non-histone chromosomal proteins, including RNA polymerase and ornithine decarboxylase. Phosphorylated ornithine decarboxylase is inactive enzymatically but, in Physarum, it binds to the rDNA minichromosome and stimulates rRNA transcription. Kinases forming phosphoramidate bonds occur in a variety of rat tissues and form phosphohistide in historic H4 and phospholysine in histone H1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rosen, R. O. and Krebs, E. G., 1981. Cold Spring Harbor Conferences on Cell Proliferation 8.

  2. Weller, M., 1979. Protein Phosphorylation. Academic Press, New York.

    Google Scholar 

  3. Cohen, P., 1980. Recently Discovered Systems of Enzyme Regulation by Reversible Phosphorylation. Elsevier/ North-Holland, Amsterdam.

    Google Scholar 

  4. Meisler, M. H. and Langan, T. A., 1969. J. Biol. Chem. 244:4961–4968.

    Article  CAS  PubMed  Google Scholar 

  5. Farron-Furstenthal, F., 1980. J. Biol. Chem. 255: 4589–4594.

    Google Scholar 

  6. Farron-Furstenthal, F., 1979. Nature 280: 415–417.

    Google Scholar 

  7. Zeilig, C. E., Langan, T. A. and Glass, D. B., 1981. J. Biol. Chem. 256: 994–1001.

    Google Scholar 

  8. Walton, G. M. and Gill, G. N., 1981. J. Biol. Chem. 256: 1681–1688.

    Google Scholar 

  9. Neuman, J., Whittaker, R., Blanchard, B. and Ingram, V., 1979. Nucl. Acids Res. 5: 1675–1687.

    Google Scholar 

  10. Defers, N., Kitzis, A., Levy, F., Tichonicky, L., Sabatier, M.-M. and Kruh, J., 1978. Eur. J. Biochem. 88: 583–591.

    Google Scholar 

  11. Chan, P. K. and Liew, C. C., 1977. Can. J. Biochem. 55: 847–855.

    Google Scholar 

  12. McGhee, J. D. and Felsenfeld, G., 1980. Ann. Rev. Biochem. 49: 1115–1156.

    Google Scholar 

  13. Allan, J., Hartman, P. G., Crane-Robinson, C. and Aviles, F. X., 1980. Nature 288: 675–679.

    Google Scholar 

  14. Igo-Kemenes, T., Horz, W. and Zachau, H. G., 1982. Ann. Rev. Biochem. 51: 89–121.

    Google Scholar 

  15. Thoma, F., Koller, Th. and King, A., 1979. J. Cell. Biol. 83: 403–427.

    Google Scholar 

  16. Langan, T. A., 1978. Methods on Cell Biology (Stein, G. S. and Stein, J., eds.), Vol. 19, pp. 127–142, Academic Press, New York.

  17. Cole, R. D., 1977. Molecular Biology of the Mammalian Genetic Apparatus, Vol. I, p. 93, North-Holland, Amsterdam.

    Google Scholar 

  18. Ajiro, K., Borun, T. W., Shulman, S. D., McFadden, G. M. and Cohen, L. H., 1981. Biochemistry 20: 1454–1464.

    Google Scholar 

  19. Langan, T. A., 1982. J. Biol. Chem. 257: 14835–14846.

    Google Scholar 

  20. Kurochkin, S. N., Trakht, I. N., Severin, E. S. and Cole, R. D., 1977. FEBS Lett. 84: 163–166.

    Google Scholar 

  21. Lake, R. S., 1973. Nature New Biol. 242: 145–146.

    Google Scholar 

  22. Langan, T. A., Zeilig, C. E. and Leichtling, B., 1980. Protein Phosphorylation and Bio-regulation (Thomas, G., Podesta, E. J. and Gordon, J., eds.), pp. 70–82, S. Karger, Basel.

  23. Ajiro, K., Borun, T. W. and Cohen, L. H., 1981. Biochemistry 20: 1445–1454.

    Google Scholar 

  24. Langan, T. A., 1978. Methods in Cell Biology (Stein, G. S. and Stein, J., eds.), Vol. 19, pp. 143–152, Academic Press, New York.

  25. Phillips, I. R., Shephard, E. A., Stein, J. L., Kleinsmith, L. and Stein, G. S., 1979. Biochem. Biophys. Acta 565: 326–346.

    Google Scholar 

  26. Hardie, D. G., Matthews, H. R. and Bradbury, E. M., 1976. Eur. J. Biochem. 66: 37–42.

    Google Scholar 

  27. Chambers, T. C., Langan, T. A., Matthews, H. R. and Bradbury, E. M., 1983. Biochemistry 22: 30–37.

    Google Scholar 

  28. Trakht, N. N., Grozdova, I. D., Severin, E. S. and Gnuchev, N. V., 1980. Biokhimiya 45: 636–643.

    Google Scholar 

  29. Lake, R. S. and Salzman, N. P., 1972. Biochemistry 11: 4817–4826.

    Google Scholar 

  30. Lake, R. S., Goidl, J. A. and Salzman, N. P., 1972. Exp. Cell Res. 73: 113–121.

    Google Scholar 

  31. Lake, R. S., 1973. J. Cell Biol. 58: 317–333.

    Google Scholar 

  32. Shoemaker, C. B. and Chalkley, R., 1978. J. Biol. Chem. 253:5802–5807.

    Google Scholar 

  33. Shoemaker, C. B. and Chalkley, R., 1980. J. Biol. Chem. 255:11048–11055.

    Google Scholar 

  34. Masarachia, R. A., Kemp, B. E. and Walsh, D. A., 1977. J. Biol. Chem. 252: 7109–7117.

    Google Scholar 

  35. Halleck, M. S. and Gurley, L. R., 1980. Exp. Cell Res. 125: 377–388.

    Google Scholar 

  36. Gurley, L. R., D'Anna, J. A., Barham, S. S., Deaven, L. L. and Tobey, R. A., 1978. Eur. J. Biochem. 84: 1–16.

    Google Scholar 

  37. Paulson, J. R. and Taylor, S. S., 1982. J. Biol. Chem. 257: 6064–6072.

    Google Scholar 

  38. Whitlock, J. P., Jr., Augustine, R. and Schulman, H., 1980. Nature 287: 74–76.

    Google Scholar 

  39. Whitlock, J. P., Jr., Goleazzi, D. and Schulman, H., 1983. J. Biol. Chem. 258: 1299–1304.

    Google Scholar 

  40. Zeilig, C. E. and Langan, T. A., 1980. Biochem. Biophys. Res. Commun. 95: 1372–1379.

    Google Scholar 

  41. Masarachia, R. A., Maller, J. L. and Walsh, D. A., 1979. Arch. Biochem. Biophys. 194: 1–12.

    Google Scholar 

  42. Bradbury, E. M., Inglis, R. J. and Matthews, H. R., 1974. Nature 247: 257–261.

    Google Scholar 

  43. Schlepper, J. and Knippers, R., 1975. Eur. J. Biochem. 60: 209–220.

    Google Scholar 

  44. Quirin-Stricker, C. and Schmit, M., 1981. Eur. J. Biochem. 118:165–172.

    Google Scholar 

  45. Ashby, C. D. and Walsh, D. A., 1972. J. Biol. Chem. 247: 6637–6642.

    Google Scholar 

  46. Bustin, M. and Cole, R. D., 1969. J. Biol. Chem. 244: 5286–5289.

    Google Scholar 

  47. Bustin, M. and Cole, R. D., 1968. J. Biol. Chem. 243: 4500–4505.

    Google Scholar 

  48. Matthews, H. R., 1980. Recently Discovered Systems of Enzyme Regulation by Reversible Phosphorylation (Cohen, P., ed.), pp. 235–254, Elsevier/North- Holland.

  49. Cooper, E., Palmer, R. J. and Spaulding, S. W., 1981. Nucl. Acids Res. 9: 3389–3401.

    Google Scholar 

  50. Matthews, H. R. and Bradbury, E. M., 1978. Exp. Cell Res. 111: 343–351.

    Google Scholar 

  51. Corbett, S., Bradbury, E. M. and Matthews, H. R., 1980. Exp. Cell Res. 128: 127–132.

    Google Scholar 

  52. Mitchelson, K., Chambers, T., Bradbury, E. M. and Matthews, H. R., 1978. FEBS Lett. 92: 339–342.

    Google Scholar 

  53. Laks, M. S., Harrison, J. J., Schwoch, G. and Jungmann, R. A., 1981. J. Biol. Chem. 256: 8775–8785.

    Google Scholar 

  54. Gray, J. P., Johnson, R. A. and Friedman, D. L., 1980. Arch. Biochem. Biophys. 202: 259–276.

    Google Scholar 

  55. Balhorn, R., Balhorn, M., Morris, H. P. and Chalkley, R., 1972. Cancer Res. 32: 1775–1784.

    Google Scholar 

  56. Marks, D. B., Paik, W. K. and Borun, T. W., 1973. J. Biol. Chem. 248: 5660–5667.

    Google Scholar 

  57. Balhorn, R., Riecke, O. and Chalkley, R., 1971. Biochemistry 10: 3952–3959.

    Google Scholar 

  58. Inglis, R. J., Langan, T. A., Matthews, H. R., Hardie, D. G. and Bradbury, E. M., 1976. Exp. Cell Res. 97: 418–425.

    Google Scholar 

  59. Bradbury, E. M., Inglis, R. J., Matthews, H. R. and Langan, T. A., 1974. Nature 249: 553–556.

    Google Scholar 

  60. Trakht, I. N., Grozdova, I. D., Gulyaev, N. N., Severin, E. S. and Gnuchev, N. V., 1980. Biokhimiya 45: 788–793.

    Google Scholar 

  61. Matsumoto, Y., Hasuda, H., Mita, S., Marunouchi, T. and Yamada, M., 1980. Nature 284: 181–183.

    Google Scholar 

  62. Marunouchi, T., Yasuda, H., Matsumoto, Y. and Tamada, M., 1980. Biochem. Biophys. Res. Commun. 95: 126–131.

    Google Scholar 

  63. Goldknopf, I. L. and Busch, H., 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 864–868.

    Google Scholar 

  64. Busch, H. and Goldknopf, I. L., 1981. Mol. Cell Biochem. 40:173–188.

    Google Scholar 

  65. Walsh, D. A. and Cooper, R. H., 1979. Biochemical Actions of Hormones (Litwack, G. ed.), Vol. 6, pp. 1–175, Academic Press, New York.

  66. Builder, S. E., Beavo, J. A. and Krebs, E. G., 1981. Protein Phosphorylation (Rosen, O. M. and Krebs, E. G., eds.), Vol. 8, pp. 33–44, Cold Spring Harbor Conferences on Cell Proliferation.

  67. Traugh, J. A., Ashby, C. D. and Walsh, D. A., 1974. Methods in Enzymol. 38: 290–298.

    Google Scholar 

  68. Spielvogel, A. M., Mednieks, M. I., Eppenberger, U. and Jungmann, R. A., 1977. Eur. J. Biochem. 73: 199–212.

    Google Scholar 

  69. Palmer, W. K., Castagna, M. and Walsh, D. A., 1974. Biochem. J. 143: 469–471.

    Google Scholar 

  70. Castagna, M., Palmer, W. K. and Walsh, D. A., 1975. Eur. J. Biochem. 55: 193–199.

    Google Scholar 

  71. Johnson, E. M., Hadden, J. W., Inoue, A. and Allfrey, V. G., 1975. Biochemistry 14: 3873–3884.

    Google Scholar 

  72. Jungmann, R. A. and Kranias, E. G., 1977. Int. J. Biochem. 8: 819–830.

    Google Scholar 

  73. Hayashi, H., Nomoto, M. and Iwai, K., 1980. Proc. Japan Acad. Ser. B 56: 579–584.

    Google Scholar 

  74. Harrison, J. J., Schwoch, G., Schweppe, J. S. and Jungmann, R. A., 1982. J. Biol. Chem. 257: 13062–13069.

    Google Scholar 

  75. Mallette, L. E., Neblett, M., Exton, J. H. and Langan, T. A., 1973. J. Biol. chem. 248: 6289–6291.

    Google Scholar 

  76. Mednieks, M. I. and Jungmann, R. A., 1982. Arch. Biochem. Biophys. 213: 127–138.

    Google Scholar 

  77. Jungmann, R. A., Hiestand, P. C. and Schweppe, J. S., 1974. Endocrinology 94: 168–183.

    Google Scholar 

  78. Steiner, A. L., Koide, Y., Earp, H. S., Bechtel, P. J. and Beavo, J. A., 1978. Adv. Cyclic Nucleotide Res. 9: 691–705.

    Google Scholar 

  79. DeVellis, J. and Brooker, G., 1973. Tissue Culture of the Nervous System (Sato, G., ed.), pp. 231–246, Plenum Press, New York.

  80. Bottenstein, J. E. and DeVellis, J., 1978. Life Sci. 23: 821–834.

    Google Scholar 

  81. Derda, D. F., Miles, M. F., Schweppe, J. S. and Jungmann, R. A., 1980. J. Biol. Chem. 255: 11112–11121.

    Google Scholar 

  82. Kumar, S., McGinnis, J. F. and DeVellis, J., 1980. J. Biol. Chem. 255: 2315–2327.

    Google Scholar 

  83. Miles, M. F., Hung, P. and Jungmann, R. A., 1981. J. Biol. Chem. 256: 12545–12552.

    Google Scholar 

  84. Langan, T. A., 1969. J. Biol. Chem. 244: 5763–5765.

    Google Scholar 

  85. Langan, T. A., 1969. Proc. Natl. Acad. Sci. U.S.A. 64: 1276–1283.

    Google Scholar 

  86. Wicks, W. D., Koontz, J. and Wagner, K., 1975. J. Cyclic Nucl. Res. 1: 49–59.

    Google Scholar 

  87. Stein, G. S., Spelsberg, T. C. and Kleinsmith, L. J., 1974. Science 183: 817–824.

    Google Scholar 

  88. Kranias, E. G., Schweppe, J. S. and Jungmann, R. A., 1977. J. Biol. Chem. 252: 6750–6758.

    Google Scholar 

  89. Walton, G. M., Spiess, J. and Gill, G. N., 1982. J. Biol. Chem. 257: 4661–4668.

    Google Scholar 

  90. Keely, S. L., Corbin, J. D. and Park, C. R., 1975. Proc. Natl. Acad. Sci. U.S.A. 72: 1501–1504.

    Google Scholar 

  91. Fletcher, W. H. and Byus, C. V., 1982. J. Cell Biol. 93: 719–726.

    Google Scholar 

  92. Byus, C. V. and Fletcher, W. H., 1982. J. Cell Biol. 93: 727–734.

    Google Scholar 

  93. Corbin, J. D., Keely, S. L. and Park, C. R., 1975. J. Biol. Chem. 250: 218–225.

    Google Scholar 

  94. Miyamoto, E., Petzgold, G. L., Harris, J. S. and Greengard, P., 1971. Biochem. Biophys. Res. Commun. 44: 305–312.

    Google Scholar 

  95. Guidotti, A., Chuang, D. M., Hollenbeck, R. and Costa, E., 1978. Adv. Cyclic Nucleotide Res. 9: 185–197.

    Google Scholar 

  96. Christensen, M., Schweppe, J. S. and Jungmann, R. A., 1979. Exp. Cell Res. 124: 15–24.

    Google Scholar 

  97. Oleinick, N. L., Daniel, J. W. and Brewer, E. N., 1981. Exp. Cell Res. 131: 372–378.

    Google Scholar 

  98. Lovely, J. R. and Threlfall, R. J., 1976. Biochem. Biophys. Res. Commun. 71: 789–795.

    Google Scholar 

  99. Kish, V. M. and Kleinsmith, L. J., 1974. J. Biol. Chem. 249:750–760.

    Google Scholar 

  100. Takeda, M., Yamamura, H. and Ohga, Y. B., 1971. Biochem. Biophys. Res. Commun. 42: 103–110.

    Google Scholar 

  101. Kamiyama, M. and Dastugue, B., 1971. Biochem. Biophys. Res. Commun. 44: 29–36.

    Google Scholar 

  102. Ruddon, R. W. and Anderson, S. L., 1972. Biochem. Biophys. Res. Commun. 46: 1499–1508.

    Google Scholar 

  103. Desjardins, P. R., Liew, C. C. and Gornall, A. G., 1975. Can. J. Biochem. 53: 354–363.

    Google Scholar 

  104. Atmar, V. J., Kuehn, G. D. and Casillas, E. R., 1981. J. Biol. Chem. 256: 8275–8278.

    Google Scholar 

  105. Bohm, J., Keil, G. and Knippers, R., 1977. Eur. J. Biochem. 78: 251–266.

    Google Scholar 

  106. Daniels, G. R., Atmar, V. J. and Kuehn, G. D., 1981. Biochemistry 20: 2525–2532.

    Google Scholar 

  107. Phillips, I. R., Shephard, E. A., Stein, J. L., Kleinsmith, L. and Stein, G. S., 1979. Biochim. Biophys. Acta 565: 326–346.

    Google Scholar 

  108. Mill, J. S., Busch, H. and Durban, E., 1982. Biochem. Biophys. Res. Commun. 109: 1222–1227.

    Google Scholar 

  109. Yutani, Y., Tei, Y., Yukioka, M. and Inoue, A., 1983. Arch. Biochem. Biophys, in press.

  110. Thornburg, W., O'Malley, A. F. and Lindell, T. J., 1978. J. Biol. Chem. 252: 4638–4641.

    Google Scholar 

  111. Dahmus, E., 1981. J. Biol. Chem. 256: 3319–3325.

    Google Scholar 

  112. Dahmus, E., 1976. Biochemistry 15: 1821–1829.

    Google Scholar 

  113. Dahmus, M. E. and Natzle, J., 1977. Biochemistry 16: 1901–1907.

    Google Scholar 

  114. Hathaway, G. M. and Traugh, J. A., 1979. J. Biol. Chem. 254: 762–768.

    Google Scholar 

  115. Thornburg, W. and Lindell, T. J., 1977. J. Biol. Chem. 252: 6660–6665.

    Google Scholar 

  116. Dahmus, M. E., 1981. J. Biol. Chem. 256: 11239–11243.

    Google Scholar 

  117. Kuehn, G. D. and Atmar, V. J., 1982. Fed. Proc. 41: 3078–3083.

    Google Scholar 

  118. Dabauvalle, M. C., Meggio, F., Creuzet, C. and Loeb, J. E., 1980. FEBS Lett. 107: 193–197.

    Google Scholar 

  119. Christmann, J. L. and Dahmus, M. E., 1981. J. Biol. Chem. 256: 3326–3331.

    Google Scholar 

  120. Ohtsuki, K., Shiraishi, H., Yamada, E., Nakamura, M. and Ishida, N., 1980. J. Biol. Chem. 255: 2391–2395.

    Google Scholar 

  121. Goodwin, G. H., Walker, J. M. and Johns, E. W., 1978. The Cell Nucleus IVA (Busch, H., ed.), 000-000 Academic press, New York.

  122. Weintraub, H. and Groudine, M., 1976. Science 193: 848–856.

    Google Scholar 

  123. Weisbrod, S., Groudine, M. and Weintraub, H., 1980. Cell 19:289–302.

    Google Scholar 

  124. Levy-Wilson, B., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 2189–2193.

    Google Scholar 

  125. Saffer, J. D. and Glazer, R. L., 1980. Biochem. Biophys. Res. Commun. 93: 1280–1285.

    Google Scholar 

  126. Paulson, J. R. and Taylor, S. S., 1982. J. Biol. Chem. 257: 6064–6072.

    Google Scholar 

  127. Taylor, S. S., 1982. J. Biol. Chem. 257: 6056–6063.

    Google Scholar 

  128. Losick, R. and Chamberlin, M., 1976. RNA Polymerase, Cold Spring Harbor Laboratory, New York.

    Google Scholar 

  129. Hirsch, J. and Martelo, O. J., 1976. J. Biol. Chem. 251: 5408–5413.

    Google Scholar 

  130. Bell, G. L., Valenzuela, P. and Rutter, W. J., 1977. J. Biol. Chem. 252: 3082–3091.

    Google Scholar 

  131. Rose, K. M., Stetler, D. A. and Jacob, S. T., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 2833–2837.

    Google Scholar 

  132. Duceman, B. W., Rose, K. M. and Jacob, S. T., 1981. J. Biol. Chem. 256: 10755–10758.

    Google Scholar 

  133. Lengyel, P., 1982. Ann. Rev. Biochem. 51: 251–282.

    Google Scholar 

  134. Mitchell, J. A., Augustine, T. A. and Wilson, J. M., 1981. Biochim. Biophys. Acta 657, 257–267.

    Google Scholar 

  135. Atmar, V. J. and Kuehn, G. D., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 5518 5522.

    Google Scholar 

  136. Atmar, V. J., Daniels, G. R. and Kuehn, G. D., 1978. Eur. J. Biochem. 90: 29–37.

    Google Scholar 

  137. Lee, E. J., Larkin, P. C. and Screevalsan, T., 1980. Biochem. Biophys. Res. Commun. 97: 301–308.

    Google Scholar 

  138. Kuehn, G. D., Affolter, U.-U., Atmar, V. J., Seebeck, T., Gubler, U. and Braun, R., 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 2541–2545.

    Google Scholar 

  139. Vogt, V. and Braun, R., 1976. J. Mol. Biol. 106: 567–587.

    Google Scholar 

  140. Seebeck, T., Stalder, J. and Braun, R., 1979. Biochemistry 18:484–490.

    Google Scholar 

  141. Molgaard, H. V., Matthews, H. R. and Bradbury, E. M., 1976. Eur. J. Biochem. 68: 541–549.

    Google Scholar 

  142. Atmar, V. J., Daniels, G. R., Kuehn, G. D. and Braun, R., 1980. FEBS Lett. 114: 205–208.

    Google Scholar 

  143. Chen, C. C., Bruegger, B. B., Kern, C. W., Lin, Y. C., Halpern, R. M. and Smith, R. A., 1977. Biochemistry 16: 4852–4855.

    Google Scholar 

  144. Bieber, L. L. and Boyer, P. D., 1966. J. Biol. Chem. 241: 5375–5383.

    Google Scholar 

  145. Gassner, M., Stehlik, D., Schrecker, O., Hengstenberg, W., Maurer, W. and Ruterjans, H., 1977. Eur. J. Biochem. 75:287–296.

    Google Scholar 

  146. Fujitaki, J. M., Fung, G., Oh, E. Y. and Smith, R. A., 1981. Biochemistry 20: 3658–3664.

    Google Scholar 

  147. Steiner, A. W., Helander, E. R., Fujitaki, J. M., Smith, L. S. and Smith, R. A., 1980. J. Chromatogr. 202: 263–269.

    Google Scholar 

  148. Smith, L. S., Kern, C. W., Halpern, R. M. and Smith, R. A., 1976. Biochem. Biophys. Res. Commun. 71: 459–465.

    Google Scholar 

  149. Zetterqvist, O. and Engstrom, L., 1966. Biochim. Biophys. Acta 113: 520–530.

    Google Scholar 

  150. Wang, T. Y., 1967. J. Biol. Chem. 242, 1220–1226.

    Google Scholar 

  151. Smith, D. L., Bruegger, B. B., Halpern, R. M. and Smith, R. A., 1973. Nature 246: 103–104.

    Google Scholar 

  152. Smith, D. L., Chen, C.-C., Bruegger, B. B., Holtz, S. L., Halpern, R. M. and Smith, R. A., 1974. Biochemistry 13: 3780–3785.

    Google Scholar 

  153. DeLange, R. J., Famborough, D. M., Smith, E. L. and Bonner, J., 1969. J. Biol. Chem. 244: 319–334.

    Google Scholar 

  154. Lewis, P. N., Bradbury, E. M. and Crane-Robinson, C., 1975. Biochemistry 14: 3391–3400.

    Google Scholar 

  155. Langan, T. A., Rall, S. C. and Cole, R. D., 1971. J. Biol. Chem. 246: 1942–1944.

    Google Scholar 

  156. Jones, G. M. T., Rall, S. C. and Cole, R. D., 1974. J. Biol. Chem. 249: 2548–2553.

    Google Scholar 

  157. Bucher, N. L. R. and Malt, R. A., 1971. Regeneration of Liver and Kidney, pp. 38–50, Little, Brown and Company, Boston.

    Google Scholar 

  158. Lehninger, A. L., 1975. Biochemistry, Worth Publ. Inc., New York.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departmentof Biological Chemistry, School of Medicine, University of California, 95616, Davis, CA, U.S.A.

    Harry R. Matthews & Verena D. Huebner

Authors
  1. Harry R. Matthews
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Verena D. Huebner
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matthews, H.R., Huebner, V.D. Nuclear protein kinases. Mol Cell Biochem 59, 81–99 (1984). https://doi.org/10.1007/BF00231306

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00231306

Keywords

Search

Navigation