Summary
Histological and quantitative studies were carried out in dentate nucleus (DN) of 14 human fetuses of gestational ages ranging from 10 weeks to 28 weeks in Nissl stained sections. The dentate nucleus was already well delineated at 11 weeks, but the adult profile was attained only by 27–28 weeks. The magnocellular dorsomedial region and the parvocellular ventrolateral region became apparent at 17–18 weeks. The numerical density of neurons showed a steady decline with advancing gestational age. However, the absolute neuronal count until 19–20 weeks was 367.1 × 103 followed by a count of 249.5 × 103 at 22–23 weeks. The reduction in the count between the two periods was significant and coincided with cell death which was striking between 19 and 23 weeks. The glial cell population continued to increase with advancing gestational age. The occurrence of significant neuronal cell death and its probable role in the developing human DN is reported for the first time.
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References
Braak H, Braak E (1983) Morphological studies of local circuit neurons in the cerebellar dentate nucleus of man. Human Neurobiol 2: 49–57
Brun R (1917) Das Kleinhirn: Anatomie, Physiologie und Entwicklungsgeschichte. Abhandl Neurol Psychiat Schweiz Arch Neurol Psychiat 7: 1–77
Chan Palay V (1977) Cerebellar dentate nucleus. Springer, Berlin, Heidelberg, New York
Cowan WM, Fawcett JW, O'Leary DDM, Stanfield BB (1984) Regressive events in neurogenesis. Science 225: 1258–1265
Daron DH (1960) Morphology of the cerebellar dentate nucleus in a chimpanzee. Anat Rec 138: 81–92
Demole V (1927) Structure et connexions des noyaux dentales du cervelet. Schweiz Arch Neurol Psychiat 20: 271–294
Fix JD, Treff WM (1970) Structural principles of the phylogenetic development of the cerebellar nuclei in primates. Acta Anat 76: 337–351
Hamilton WJ, Boyd JD, Mossmann WH (1972) Human embryology. W Heffer and Sons Ltd, Cambridge
Hassler R (1959) Über die Afferent Bahnen and Thalmuskerne des motorischem Systems des Grosshirns. Arch Psychiat Z Ges Neurol 182: 759–785
Hayaran A, Wadhwa S, Bijlani V (1991) Configurational and volumetric changes of the early prenatal human cerebellar dentate nucleus. Acta Anat 141: 274–281
Hayashi M (1924) Einige wichtige Tatsachen aus der ontogenetischen Entwicklung des menschlichen Kleinhirns. Dent Z Nervenheik 81: 74–82
Heidary H, Tomasch J (1969) Neuron numbers and perikaryon areas in the human cerebellar nuclei. Acta Anat 74: 290–296
Hopker W (1951) Das Altern des nucleus dentatus. Z Alternsforsch 5: 256–277
Jakob A (1928) Das Kleinhirn. In: Mollendorff. Handbuch der mikroskopischen Anatomie des menschen. Springer, Berlin, Heidelberg, New York IV/1 pp 674
Koster S (1926) Two cases of hypoplasia ponto-cerebellaris. Acta Psychiat 1: 47–83
Murofushi K (1974) Normal development and dysgenesias of the dentate nucleus and inferior olive. Acta Neuropath (Berl) 27: 317–328
Owaki S (1958) Development of the dentate nucleus. Med Biol 45: 151–155
Rakic P, Sidman RL (1970) Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. J Comp Neurol 139: 473–500
Steindler DA, Cooper NGF (1987) Glial and glycoconjugate boundaries during postnatal development of the central nervous system. Dev Brain Res 36: 27–38
Tolbert LP, Oland LA (1989) A role for glia in the development of organized neuropilar structures. TINS 12 2: 70–75
Verbitzkaya JB (1969) Some aspects of the ontophylogenesis of the cerebellum. In: Llinas R (ed) Neurobiology of cerebellar evolution and development. American Medical Association, Chicago, pp 859–874
Vogt H, Astwazaturow M (1912) Über ageborene Kleinhirnerkrankungen mit Beiträgen zur Entwicklungsgeschichte des Kleinhirns. Arch Psychiat Nervenkrankh 49: 75–203
Wadhwa S, Gopinath G, Bijlani V (1985) Nissl and Golgi analysis of the developing human cerebellar nuclei in the early prenatal period. Ind J Med Res 81: 193–201
Weibel ER (1979) Stereological methods. Academic Press, London, vol 1
Yamaguchi K, Goto N, Yamamoto YT (1989) Development of human cerebellar nuclei. Acta Anat 136: 61–68
Zecevic N, Mihajlovic P (1982) Development of the human dentate nucleus: a Golgi and Nissl study. Neuroscience 7: S233
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Hayaran, A., Wadhwa, S., Gopinath, G. et al. Developing dentate nucleus in man: a qualitative and quantitative study. Exp Brain Res 89, 640–648 (1992). https://doi.org/10.1007/BF00229888
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DOI: https://doi.org/10.1007/BF00229888