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Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension

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Abstract

There is evidence that cardiac hypertrophy in spontaneously hypertensive rats (SHR) occurs before the development of hypertension. 1,2-Diacylglycerol, which is thought to be a second messenger activating protein kinase C, is also produced in excess in SHR hearts at 4 weeks of age, before established hypertension. We determined myocardial 1,2-diacylglycerol content in SHR with and without prazosin and enalapril from 3 to 4 weeks of age. Hearts from untreated SHR had greater RNA and DNA synthesis and greater relative weights at 4 weeks of age than those from Wistar-Kyoto (WKY) rats. There was no difference in triglyceride content or phospholipid species between WKY rats and untreated SHR, except for a higher cholesterol content in SHR. Treatment of SHR with enalapril, but not prazosin, lowered not only 1,2-diacylglycerol content but also RNA synthesis to the levels of WKY rats. Moreover, fatty acids involved in 1,2-diacylglycerol were altered by enalapril despite the lack of a difference between WKY rats and untreated SHR. Prazosin did not have any effect on 1,2-diacylglycerol fatty acid composition. Enalapril may decrease cardiac hypertrophy in SHR by lowering myocardial 1,2-diacylglycerol production.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, 466, Showa-ku, Nagoya, Japan

    Kenji Okumura, Junichiro Kondo, Mitsuhiko Yoshino, Kyosuke Ishikawa, Hiroshi Asano, Hidekazu Hashimoto & Takayuki Ito

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  1. Kenji Okumura
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  2. Junichiro Kondo
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  3. Mitsuhiko Yoshino
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  4. Kyosuke Ishikawa
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  5. Hiroshi Asano
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  6. Hidekazu Hashimoto
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  7. Takayuki Ito
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Okumura, K., Kondo, J., Yoshino, M. et al. Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension. Mol Cell Biochem 112, 15–21 (1992). https://doi.org/10.1007/BF00229638

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  • DOI: https://doi.org/10.1007/BF00229638

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