Abstract
Modulation of presynaptic inhibition of Ia afferents projecting monosynaptically to soleus motoneurones was investigated during human gait. Changes in presynaptic inhibition of Ia afferents were deduced from alterations in the amount of heteronymous soleus H-reflex facilitation evoked by a constant femoral nerve stimulation. It has been shown that this facilitation is mediated through a monosynaptic Ia pathway and that during its first 0.5 ms it is still uncontaminated by any polysynaptic effect and can be used to assess ongoing presynaptic inhibition of Ia terminals to soleus motoneurones. During gait, heteronymous facilitation was reduced with respect to its control value (rest during sitting) and modulated during the step cycle: it reached its maximum at mid-stance and decreased to near zero by the end of stance. At the same time the H-reflex amplitude was to some extent similarly modulated. It is argued that this decrease in heteronymous Ia facilitation and in H-reflex amplitude reflects an increased, ongoing presynaptic inhibition of Ia terminals projecting onto soleus motoneurones, which could be from central and/or peripheral origin. D1 inhibition, i.e. the late and long-lasting inhibition of the soleus H-reflex evoked by a train of stimuli to the common peroneal nerve, was used as another method to assess presynaptic inhibition. This D1 inhibition was decreased during gait, and it is argued that this decrease might reflect an occlusion in presynaptic pathways or increased presynaptic inhibition of pathways mediating the conditioning volley.
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References
Baev KV (1980) Polarization of primary afferent terminals in the lumbar spinal cord during fictitious locomotion. Neurophysiology 12:305–311
Berardelli A, Day BL, Marsden CD, Rothwell JC (1987) Evidence favouring presynaptic inhibition between antagonist muscle afferents in the human forearm. J Physiol (Lond) 391:71–83
Capaday C, Lavoie BA (1995) Studies of presynaptic inhibition in the stretch reflex pathway of the human and the cat. In: Taylor et al. (eds), Alpha and gamma motor systems. Plenum, New York. pp. 537–540
Capaday C, Stein RB (1986) Amplitude modulation of the soleus H-reflex in the human during walking and standing. J Neurosci 6:1308–1313
Capaday C, Stein RB (1987) Difference in the amplitude of the human soleus H-reflex during walking and running. J Physiol (Lond) 392:513–522
Capaday C, Lavoie BA, Comeau F (1995) Differential effects of a flexor nerve input on the human soleus H-reflex during standing versus walking. Can J Physiol Pharmacol 73:436–449
Crenna P, Frigo C (1987) Excitability of the soleus H-reflex arc during walking and stepping in man. Exp Brain Res 66:49–60
Crone C, Hultborn H, Mazières L, Morin C, Nielsen J, Pierrot-Deseilligny E (1990) Sensitivity of monosynaptic test reflexes to facilitation and inhibition as a function of the test reflex size: a study in man and the cat. Exp Brain Res 81:35–45
Dietz V, Quintern JB, Berger W (1984) Corrective reactions to stumbling in man: functional significance of spinal and trans-cortical reflexes. Neurosci Lett 44:133–135
Dietz V, Faist M, Pierrot-Deseilligny E (1990) Amplitude modulation of the quadriceps H-reflex in the human during the early stance phase of gait. Exp Brain Res 79:221–224
Dueñas SH, Rudomin P (1988) Excitability changes of ankle extensor group Ia and Ib fibres during fictive locomotion in the cat. Exp Brain Res 70:15–25
El-Tohamy A, Sedgwick EM (1983) Spinal inhibition in man: depression of the soleus H reflex by stimulation of the nerve to the antagonist muscle. J Physiol (Lond) 337:497–508
Frank K, Fuortes MGF (1957) Presynaptic and postsynaptic inhibition of monosynaptic reflexes. Fed Proc 16:39–40
Gossard JP, Rossignol S (1990) Phase-dependent modulation of dorsal root potentials evoked by peripheral nerve stimulation during fictive locomotion in the cat. Brain Res 537:1–13
Gossard JP, Cabelguen JM, Rossignol S (1989) Rhythmic fluctuations of membrane potential and antidromic discharges of identified muscle primary afferents during fictive locomotion in the cat. Soc Neurosci Abstr 15:393
Gracies JM, Pierrot-Deseilligny E, Robain G (1994) Evidence for further recruitment of group I fibres with high stimulus intensities when using surface electrodes in man. Electroencephalogr Clin Neurophysiol 93:353–357
Hultborn H, Meunier S, Morin C, Pierrot-Deseilligny E (1987a) Assessing changes in presynaptic inhibition of Ia fibres: a study in man and the cat. J Physiol (Lond) 389:729–756
Hultborn H, Meunier S, Pierrot-Deseilligny E, Shindo M (1987b) Changes in presynaptic inhibition of Ia fibres at the onset of voluntary contraction in man. J Physiol (Lond) 389:757–772
Katz R, Meunier S, Pierrot-Deseilligny E (1988) Changes in presynaptic inhibition of Ia fibres in man while standing. Brain 111;417–437
Kernell D, Hultborn H (1990) Synaptic effects on recruitment gain: a mechanism of importance for the input-output relations of motoneurone pools? Brain Res 507:176–179
Lev-Tov A, Pinco M (1992) In vitro studies of prolonged depression in the neonatal rat spinal cord. J Physiol (Lond) 447:149–69
Llewellyn M, Prochazka A, Vincent S (1987) Transmission of human tendon jerk reflexes during stance and gait. J Physiol (Lond) 382:82 p
Llewellyn M, Yang JF, Prochazka A (1990) Human H-reflexes are smaller in difficult beam walking than in normal treadmill walking. Exp Brain Res 83:22–28
Meunier S, Morin C (1989) Changes in presynaptic inhibition of Ia fibres to soleus MNs during voluntary dorsiflexion of the foot. Exp Brain Res 76:510–518
Meunier S, Pierrot-Deseilligny E (1989) Gating of the afferent volley of the monosynaptic stretch reflex during movement in man. J Physiol (Lond) 419:753–763
Misiaszek JE, Barclay JK, Brooke JD (1995) Inhibition of canine H reflexes during locomotor-like rotation about the knee arises from muscle mechanoreceptors in quadriceps. J Neurophysiol 73:2499–2506
Mizuno Y, Tanaka R, Yanagisawa N.(1971) Reciprocal group I inhibition of triceps surae motoneurones in man. J Neurophysiol 34:1010–1017
Morin C, Katz R, Mazières L, Pierrot-Deseilligny E (1982) Comparison of soleus H reflex facilitation at the onset of soleus contractions produced voluntarily and during the stance phase of human gait. Neurosci Lett 33:47–53
Nielsen J, Kagamihara Y (1993) Differential projection of the sural nerve of early and late recruited human tibialis anterior motor units: change of recruitment gain. Acta Physiol Scand 147:385–401
Nielsen J, Petersen N (1994) Is presynaptic inhibition distributed to corticospinal fibres in man ? J Physiol (Lond) 477:47–58
Rudomin P (1990) Presynaptic inhibition of muscle spindle and tendon organ afferents in mammalian spinal cord. Trends Neurosci 13:499–505
Rudomin P, Jimenez I, Enriquez M (1991) Effects of stimulation of group I afferents from flexor muscles on heterosynaptic facilitation of monosynaptic reflexes produced by Ia and descending inputs: a test for presynaptic inhibition. Exp Brain Res 85:93–102
Schmidt RF (1971) Presynaptic inhibition in the vertebrate central nervous system. Ergebn Physiol 63:20–101
Suntherland DH, Cooper L, Daniel D (1980) The role of the ankle plantar flexors in normal walking. J Bone Joint Surg 62:354–363
Tanaka R (1974) Reciprocal Ia inhibition during voluntary movements in man. Exp Brain Res 21:529–540
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Faist, M., Dietz, V. & Pierrot-Deseilligny, E. Modulation, probably presynaptic in origin, of monosynaptic Ia excitation during human gait. Exp Brain Res 109, 441–449 (1996). https://doi.org/10.1007/BF00229628
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DOI: https://doi.org/10.1007/BF00229628