Summary
Vascular disorders comprise a wide range of diverse disease entities. Correspondingly, vessels, and even more so the endothelia which line them, show a remarkable extent of heterogeneous differentiation, e.g. between the blood vascular and lymphatic systems, along the length of the vascular trees, and in the microvascular beds of various organs. The most important morphologic criterion to discriminate between endothelia is continuity (continuous endothelial cell layer and well-formed basement membrane) versus discontinuity (intra- or intercellular gaps and/or reduced or missing basement membrane). Most blood vascular endothelia are of the continuous type, while most sinusoidal and lymphatic endothelia are discontinuous by these criteria. Antigen expression corroborates these morphologic data in that CD31, CD34, and 11710 antigen are exclusively expressed in continuous endothelia, while MS-1 antigen is preferentially expressed in non-continuous sinusoidal endothelia. In contrast, no specific marker has as yet been described for lymphatic endothelia. Endothelial heterogeneity substantially contributes to the pathogenesis of vascular disorders. For example, in patients with acquired immunodeficiency syndrome the same infectious agent may cause either bacillary angiomatosis (a lobular capillary proliferation) or peliosis (sinusoidal dilatation, endothelial denudation, and development of blood-filled cysts) depending on whether the affected organs have predominantly continuous endothelia or noncontinuous sinusoidal endothelia. Moreover, in Kaposi's sarcoma, it is still an open question of whether the lesion is derived from blood vascular or lymphatic endothelia (Kaposi's sarcoma cells in situ do not express the von Willebrand factor+, PAL-E+, 11710+ phenotype of mature, resting blood vascular endothelia). It is also unresolved how endothelia of either type may be differentially induced to dedifferentiate and how they are recruited into the lesion. Clearly, knowledge about endothelial heterogeneity is still too incomplete to identify the actual mechanisms and molecules that govern the pathogenesis of vascular disorders (including still others than those mentioned here such as atherosclerosis, diabetic angiopathy, and rheumatoid arthritis) affecting distinct endothelia. Further efforts in antigenic phenotyping and in cell and molecular biology of heterogeneously differentiated endothelia should be made to improve this state of affairs.
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Abbreviations
- vWF:
-
von Willebrand factor
- PECAM-1:
-
platelet-endothelial cell adhesion molecule-1
- CD:
-
cluster of differentiation
- AIDS:
-
acquired immunodeficiency syndrome
- HIV:
-
human immunodeficiency virus
- ELAM-1:
-
endothelialleukocyte adhesion molecule-1
- VCAM-1:
-
vascular adhesion molecule-1
- MAb:
-
monoclonal antibody
References
Center for Disease Control Task Force on Kaposi's sarcoma and opportunistic infections (1982) Special report, epidemiological aspects of the current outbreak of Kaposi's sarcoma and opportunistic infections. N Engl J Med 306:248–252
Ackerman NB, Hechmer PA (1978) Studies on the capillary permeability of experimental liver metastases. Surg Gynecol Obstet 146:884–888
Adany R, Glukhova MA, Kabakov AY, Muszbek L (1988) Characterization of connective tissue cells containing factor XIII subunit a. J Clin Pathol 41:49–56
Alles JU, Bosslet K (1986) Immunohistochemical and immunochemical characterization of a new endothelial cell-specific antigen. J Histochem Cytochem 34:209–214
Asch AS, Barnwell J, Silverstein RL, Nachman RL (1987) Isolation of the thrombospondin membrane receptor. J Clin Invest 79:1054–1061
Auerbach R, Alby L, Grieves J, Joseph J, Lindgren C, Morrisey LW, Sidky YA, Tu M, Watt SL (1982) Monoclonal antibody against angiotensin-converting and human endothelial cells. Proc Natl Acad Sci USA 79:7891–7895
Beckstead JH, Wood GS, Fletcher V (1985) Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium. Am J Pathol 119:294–300
Beral V, Peterman TA, Berkelman RL, Jaffe HW (1990) Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 335:123–128
Berens von Rautenfeld D, Lubach D, Wenzel-Hora B, Klanke J, Hunneshagen C (1987) New techniques of demonstrating lymph vessels in skin biopsy specimens and intact skin with the scanning electron microscope. Arch Dermatol Res 279:327–334
Beschorner WE, Civin CI, Strauss LC (1985) Localization of hemopoietic progenitor cells in tissue with the anti-My-10 monoclonal antibody. Am J Pathol 119:1–4
Biberfeld P, Gendelman R, Hoffman J, Nakamura S, Sakurada S, Gill P, Kaplan M, Salahuddin Z, Gallo RC (1990) Characterization of cultured AIDS-Kaposi's sarcoma-derived cells (AIDS-KS). AIDS Res Hum Retroviruses 6:110
Billroth T (1861) Zur normalen und pathologischen Anatomie der menschlichen Milz. Archiv Pathol Anat 20:409–425
Bjoerkman SE (1947) The splenic circulation. Acta Med Scand [Suppl] 191:1–89
Bloom AA, Giddings JC, Wilks CJ (1973) Factor VIII on the vascular intima: possible importance in hemostasis and thrombosis. Nature 241:217–219
Buckley PJ, Dickson SA (1984) Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells. Am J Clin Pathol 82:167–172
Buckley PJ, Dickson SA, Walker WS (1985) Human splenic sinusoidal lining cells express antigens associated with monocytes, macrophages, endothelial cells, and T lymphocytes. J Immunol 134:2310–2315
Butcher EC (1990) Cellular and molecular mechanisms that direct leucocyte traffic. Am J Pathol 136:3–11
Cerio R, Griffiths CEM, Cooper KD, Nickoloff BJ, Headington JT (1989) Characterization of factor XIIa positive dermal dendritic cells in normal and inflamed skin. Br J Dermatol 121:421–431
Clifton EE, Wolstenholme JT (1949) Hypervolemia and associated changes in mice bearing a transplanted granulosa cell tumor. Cancer Res 9:331–335
Cockerell CJ, Le Boit PE (1990) Bacillary angiomatosis: a newly characterized, pseudoneoplastic, infectious, cutaneous vascular disorder. J Am Acad Dermatol 22:501–512
Delli-Bovi P, Donti E, Knowles DM II, Friedman-Kien AE, Luciw PA, Dina D, Dalla-Favera R, Basilico C (1986) Presence of chromosomal abnormalities and lack of AIDS retrovirus DNA sequences in AIDS-associated Kaposi's sarcoma. Cancer Res 46:6333–6338
Dictor M, Andersson C (1988) Lymphaticovenous differentiation in Kaposi's sarcoma. Am J Pathol 130:411–417
Dorfman RF (1988) Kaposi's sarcoma: evidence supporting its origin from the lymphatic system. Lymphology 21:45–52
Drenckhahn D, Wagner J (1986) Stress fibers in the splenic sinus endothelium in situ: molecular structure, relationship to the extracellular matrix, and contractility. J Cell Biol 102:1738–1747
Duijvestijn AM, Horst E, Pals ST, Rouse BN, Steere AC, Picker LJ, Meijer CJLM, Butcher EC (1988) High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452. Am J Pathol 130:147–155
Eisenstein BI (1990) New opportunistic infections — more opportunities. N Engl J Med 323:1625–1627
Ensoli B, Nakamura S, Salahuddin SZ, Biberfeld P, Larsson L, Beaver B, Wong-Staal F, Gallo RC (1989) AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science 243:223–226
Ensoli B, Barillari G, Salahuddin SZ, Gallo RC, WongStaal F (1990) Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature 345:84–86
Fear JD, Jackson P, Gray C, Miloszewski KJA, Losowsky MS (1984) Localization of factor XIII in human tissues using an immunoperoxidase technique. J Clin Pathol 37:560–563
Fina L, Molgaard HV, Robertson D, Bradley NJ, Monaghan P, Delia D, Sutherland DR, Baker MA, Greaves MF (1990) Expression of the CD34 gene in vascular endothelial cells. Blood 75:2417–2426
Friedman-Kiev AE, Saltzman BR (1990) Clinical manifestation of classical, endemic African, and epidemic AIDS-associated kaposi's sarcoma. J Am Acad Dermatol 22:1237–1250
Garcia FU, Wojta J, Broadley KN, Davidson JM, Hoover RL (1990) Bartonella bacilliformis stimulates endothelial cells in vitro and is angiogenic in vivo. Am J Pathol 136:1125–1135
Garcia RL, Khan MK, Berlin RB (1982) Peliosis of the spleen with rupture. Hum Pathol 13:177–179
Geisler W (1931) Über die sogenannte Peliosis der Leber. Virchows Arch Path Anat 280:565–578
Gerli R, Ibba L, Fruschelli C (1990) A fibrillar elastic apparatus around human lymph capillaries. Anat Embryol 181:281–286
Goerdt S, Steckel F, Schulze-Osthoff K, Hagemeier H-H, Macher E, Sorg C (1989) Characterization and differential expression of an endothelial cell-specific surface antigen in continuous and sinusoidal endothelia, in skin vascular lesions and in vitro. Exp Cell Biol 57:185–192
Goerdt S, Walsh LJ, Murphy GF, Pober JS (1991) Identification of a novel high molecular weight protein antigen preferentially expressed by sinusoidal endothelial cells in normal human tissues. J Cell Biol 113:1425–1437
Guarner J, Unger ER (1990) Association of Epstein-Barr virus in epithelioid angiomatosis of AIDS patients. Am J Surg Pathol 14:956–960
Hamilton FT, Lubitz JM (1952) Peliosis hepatis. AMA Arch Pathol 54:564–572
Herring BD (1963) Kaposi's sarcoma in the negro. JAMA 185:540–542
Holden CA (1989) Histogenesis of Kaposi's sarcoma and angiosarcoma of the face and scalp. J Invest Dermatol 93:119S-124S
Holthoefer H, Virtanen I, Kariniemi A-L, Hormia M, Lindner E, Miettinen A (1982) Ulex europaeus I lectin as a marker for vascular endothelium in human tissues. Lab Invest 47:60–66
Jaffe EA, Nachmann RL, Becker CG (1972) Culture of human endothelial cells derived from umbilical cord veins. J Clin Invest 51:46A (Abstr)
Jefferies WA, Brandon MR, Hunt SV, Williams AF, Gatter KC, Mason DY (1984) Transferrin receptor on endothelium of brain capillaries. Nature 312:162–163
Jimenez-Acosta F, Pardo RJ, Cohen RJ, Gould EW, Penneys NS (1990) Bacillary angiomatosis of acquired immunodeficiency syndrome: case report and literature review. J Am Acad Dermatol 22:525–529
Kaposi M (1872) Idiopathisches multiples Pigmentsarkom der Haut. Arch Derm Syph 4:265–273
Kent G, Thompson JR (1961) Peliosis hepatis. Arch Pathol 72:66–72
King JT, Puchtler H, Sweat F (1968) Ring-fibers in human spleens. Arch Pathol 85:237–245
Knowles DM II, Tolidjian B, Marboe C, D'Agati V, Grimes M, Chess L (1984) Monoclonal anti-human monocyte antibodies OKM1 and OKM5 possess distinctive tissue distributions including differential reactivity with vascular endothelium. J Immunol 132:2170–2173
Lacson A, Berman LD, Neiman RS (1979) Peliosis of the spleen. Am J Clin Pathol 71:586–590
Le Boit PE (1990) The expanding spectrum of a new disease, bacillary angiomatosis. Arch Dermatol 126:808–811
Lo S-C, Liotta LA (1985) Vascular tumors produced by NIH/3T3 cells transfected with human AIDS Kaposi's sarcoma DNA. Am J Pathol 118:7–13
Maher JJ, McGuire RF (1990) Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 86:1641–1648
Manasek FJ (1971) The ultrastructure of embryonic myocardial blood vessels. Develop Biol 26:42–54
Mangubi-Kudrjavtzewa A (1909) Über den Ban der venösen Sinus der Milz des Menschen und des Rhesusaffen. Anatomische Hefte 39:697–736
Maruyama I, Bell CE, Majerus PW (1985) Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol 101:363–371
McNutt NS, Fletcher V, Conant MA (1983) Early lesions of Kaposi's sarcoma in homosexual men. Am J Pathol 111:62–77
Meloan SN, Sweat-Waldrop F, Puchtler H, Valentine LS (1972) Cross-striated myo-endothelial cells in splenic venous sinuses. J Reticuloendothel Soc 11:566–578
Miles SA, Rezai AR, Salazar-Gonzalez JF, van der Meyden M, Stevens RH, Logan DM, Mitsuyasu RT, Taga T, Hirano T, Kishimoto T, Martinez-Maza O (1990) AIDS Kaposi sarcoma derived cells produce and respond to interleukin 6. Proc Natl Acad Sci USA 87:4068–4072
Moe RE (1963) Fine structure of the reticulum and sinuses of lymph nodes Am J Anat 112:311–335
Muller WA, Ratti CM, McDonnell SL, Cohn ZA (1989) Ahuman endothelial cell restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med 170:399–414
Naeim F, Cooper PH, Semion AA (1973) Peliosis hepatis: possible etiologic role of anabolic steroids. Arch Pathol 95:284–285
Nagura H, Koshikawa T, Fukuda Y, Asai J (1986) Hepatic vascular endothelial cells heterogeneously express surface antigens associated with monocytes, macrophages and T lymphocytes. Virchows Arch [A] 409:407–416
Nakamura S, Salahuddin SZ, Biberfeld P, Ensoli B, Markham PD, Wong-Staal F, Gallo RC (1988) Kaposi's sarcoma cells: long-term culture with growth factor from retrovirus-infected CD4+ T cells. Science 242:426–430
Nawroth PP, Handley DA, Esmon CT, Stern DM (1986) Interleukin-1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci USA 83:3460–3464
Nemes Z, Thomazy V (1986) Identification of histiocytic reticulum cells by the immunohistochemical demonstration of factor XIII (F-XIIla) in human lymph nodes. J Pathol 149:121–132
Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (1990) PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 247:1219–1222
Nickoloff BJ, Griffiths CEM (1989) Factor XIIIa-expressing dermal dendrocytes in AIDS-associated cutaneous Kaposi's sarcomas. Science 243:1736–1737
Nishio S, Ohta M, Abe M, Kitamura K (1983) Microvascular abnormalities in ethylnitrosurea (ENU)-induced rat brain tumors: structural basis for altered blood-brain barrier function. Acta Neuropathol 59:1–10
Ostrowski ML, Siddiqui T, Barnes RE, Howton MJ (1990) Vascular transformation of lymph node sinuses. Arch Pathol Lab Med 114:656–660
Penn I (1979) Kaposi's sarcoma in organ transplant recipients. Transplantation 27:8–11
Perkocha LA, Geaghan SM, Yen TSB, Nishimura SL, Chan SP, Garcia-Kennedy R, Honda G, Stoloff AC, Klein HZ, Goldman RL, Meter Van S, Ferrel LD, Le Boit PE (1990) Clinical and pathological features of bacillary peliosis hepatis in association with human immunodeficiency virus infection. N Engl J Med 323:1581–1586
Petrovic LM, Burroughs A, Scheuer PJ (1989) Hepatic sinusoidal endothelium: Ulex lectin binding. Histopathology 14:233–243
Pinkus GS, Warhol MJ, O'Connor EM, Etheridge CL, Fujiwara K (1986) Immunohistochemical localization of smooth muscle myosin in human spleen, lymph node, and other lymphoid tissues. Am J Pathol 123:440–453
Pober JS, Cotran RS (1990) The role of endothelial cells in inflammation. Transplantation 50:537–544
Pober JS, Collins T, Gimbrone Jr MA, Cotran RS, Gitlin JD, Fiers W, Krensky AM, Clayberger C, Burakoff SJ, Reiss CS (1983) Lymphocytes recognize human vascular endothelial cell and dermal fibroblast la antigen induced by recombinant immune interferon. Nature 305:726–729
Poetsch B, Grulich-Henn J, Roessing R, Wille D, Mueller-Berghaus G (1990) Identification of endothelial and mesothelial cells in human omental tissue and in omentum-derived cultured cells by specific cell markers. Lab Invest 63:841–852
Postnett DN, Marboe C, Knowles II DM, Jaffe EA, Kunkel HG (1984) A membrane antigen (HC 1) selectively present on hairy cell leukemia cells, endothelial cells, and epidermal basal cells. J Immunol 132:2700–2702
Rappersberger K, Tschachler E, Zonzits E, Gillitzer R, Hatzakis A, Kaloterakis A, Mann DL, Popow-Kraupp T, Biggar RJ, Berger R, Stratigos J, Wolff K, Stingl G (1990) Endemic Kaposi's sarcoma in human immunodeficiency virus type 1-seronegative persons: demonstration of retrovirus-like particles in cutaneous lesions. J Invest Dermatol 95:371–381
Raviola E, Karnovsky MJ (1972) Evidence for a blood thymus barrier using electron opaque tracers. J Exp Med 136:466–498
Relman DA, Loutit JS, Schmidt TM, Falkow S, Tompkins LS (1990) The agent of bacillary angiomatosis. J Engl J Med 323:1532–1580
Risau W, Hallmann R, Albrecht U, Henke-Fahle S (1986) Brain induces the expression of an early cell surface marker for blood-brain barrier-specific endothelium. EMBO J 5:3179–3183
Ross R (1988) Endothelial injury and atherosclerosis. In: Simionescu N, Simionescu M (eds) Endothelial cell biology in health and disease. Plenum Press, New York, pp 371–384
Roth WK, Werner S, Risau W, Remberger K, Hofschneider PH (1988) Cultured, AIDS-related Kaposi's sarcoma cells express endothelial cell markers and are weakly malignant in vitro. Int J Cancer 42:767–773
Ruebner BH, Watanabe K, Wand JS (1970) Lytic necrosis resembling peliosis hepatis produced by lasiocarpine in the mouse liver. Am J Pathol 60:247–257
Ruiter DJ, Schlingemann RO, Rietveld FJR, de Waal RMW (1989) Monoclonal antibody-defined human endothelial antigens as vascular markers. J Invest Dermatol 93:25S-32S
Rutgers JL, Wieczorek R, Bonetti F, Kaplan KL, Posnett DN, Friedman-Kiev AE, Knowles II DM (1986) The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma. Am J Pathol 122:493–499
Ryan TJ (1989) Structure and function of lymphatics. J Invest Dermatol 93:18S-24S
Salahuddin SZ, Nakamura S, Biberfeld P, Kaplan MH, Markham PD, Larsson L, Gallo RC (1988) Angiogenic properties of Kaposi's sarcoma-derived cells after longterm culture in vitro. Science 242:430–433
Sankey EA, More L, Dhillon AP (1990) QBEnd/10: a new immunostain for the routine diagnosis of Kaposi's sarcoma. J Pathol 161:267–271
Schlingemann RO, Dingjan GM, Emeis JJ, Blok J, Warnaar SO, Ruiter DJ (1985) Monoclonal antibody PAL-E specific for endothelium. Lab Inves 52:71–76
Schlingemann RO, Rietveld FJR, de Waal RMW, Bradley NJ, Skene AI, Davies AJS, Greaves MF, Denekamp J, Ruiter DJ (1990) Leucocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma. Lab Invest 62:690–696
Schmidt EE, MacDonald IC, Groom AC (1983) Circulatory pathways in the sinusal spleen of the dog, studied by scanning electron microscopy of corrosion casts. J Morphol 178:111–123
Schmidt EE, MacDonald IC, Groom AC (1983) The intermediate circulation in the non-sinusal spleen of the cat, studied by scanning electron microscopy of corrosion casts. J Morphol 178:125–138
Schmidt EE, MacDonald IC, Groom AC (1985) Microcirculation in mouse spleen (non-sinusal), studied by means of corrosion casts. J Morphol 186:17–29
Schmidt EE, MacDonald IC, Groom AC (1985) Microcirculation in rat spleen (sinusal), studied by means of corrosion casts, with particular reference to the intermediate pathways. J Morphol 186:1–16
Schoefl GI (1963) Studies on inflammation: III. Growing capillaries: their structure and permeability. Virchows Arch [A] 337:97–141
Schulze H-J, Ruetten A, Mahrle G, Steigleder GK (1987) Initial lesions of HIV-related Kaposi's sarcoma - a histological, immunohistological, and ultrastructural study. Arch Dermatol Res 279:499–503
Sciot R, de Vos R, van Eyken P, van der Steen K, Moerman P, Desmet VJ (1989) In situ localization of melanotransferrin (melanoma associated antigen P97) in human liver. A light- and electron microscopic immunohistochemical study. Liver 9:110–119
Scoazec J-I, Marche C, Girard P-M, Houtmann J, Durand-Schneider A-M, Saimont A-G, Benhamou J-P, Feldmann G (1988) Peliosis hepatis and sinusoidal dilatation during infection by the human immunodeficiency virus (HIV). Am J Pathol 131:38–47
Scully PA, Steinman HK, Kennedy C, Trueblood K, Frisman DM, Voland JR (1988) AIDS-related Kaposi's sarcoma displays differential expression of endothelial surface antigens. Am J Pathol 130:244–251
Slater LN, Welch DF, Hensel D, Coody DW (1990) A newly recognized fastidious gram-negative pathogen as a cause of fever and bacteremia. N Engl J Med 323:1587–1593
Snook T (1950) A comparative study of the vascular arrangements in mammalian spleens. Am J Anat 87:31–78
Sternberger NH, Sternberger LA (1987) Blood-brain barrier protein recognized by monoclonal antibody. Proc Natl Acad Sci USA 84:8169–8173
Stoeckenius W (1958) Elektronenmikroskopische Untersuchungen am Reticulum der Milz. Verb Dt Ges Path 42:351–353
Stoler MH, Bonfigho TA, Steigbigel RT, Pereira A (1983) An atypical subcutaneous infection associated with acquired immunodeficiency syndrome. Am J Clin Pathol 80:714–718
Tada T, Wakabayashi T, Kishimoto H (1983) Peliosis of the spleen. Am J Clin Pathol 79:708–713
Taxy JB (1978) Peliosis: a morphologic curiosity becomes an iatrogenic problem. Hum Pathol 9:331–340
Turner RR, Beckstead JH, Warnke RA, Wood GS (1987) Endothelial cell phenotypic diversity. Am J Clin Pathol 87:569–575
Vogel J, Hinrichs SH, Reynolds RK, Luciw PA, Jay G (1988) The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. Nature 335:606–611
Wagner DD, Marder VJ (1984) Biosynthesis of vW protein by human endothelial cells: processing steps and their intracellular localization. J Cell Biol 99:2123–2130
Wagner DD, Olmsted JB, Marder VJ (1982) Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J Cell Biol 95:355–360
Walford N, van der Wouw PA, Das PK, ten Velden JJAM, Hulsebosch HF (1990) Epithelioid angiomatosis in the acquired immunodeficiency syndrome: morphology and differential diagnosis. Histopathology 16:83–88
Walsh LL Goerdt S, Pober JS, Sueki H, Murphy GF (1991) MS-1 sinusoidal endothelial antigen is expressed by factor XIIIa+, HLA-DR+ dermal perivascular dendritic cells. Lab. Invest (in press)
Ward JD, Hatfield MG, Becker DP, Lovings ET (1974) Endothelial fenestrations and other vascular alterations in primary melanoma of the central nervous system. Cancer 34:1982–1991
Weber K, Braun-Falco O (1973) Ultrastructure of blood vessels in human granulation tissue. Arch Dermatol Forsch 248:29–44
Weibel ER, Palade GE (1962) New cytoplasmic components in arterial endothelia. J Cell Biol 23:101–112
Weiss L (1988) Cells and tissues. A textbook of histology. Urban and Schwarzenberg, Vienna
White GE, Gimbrone MA Jr, Fujiwara K (1983) Factors influencing the expression of stress fibers in vascular endothelial cells in situ. J Cell Biol 97:416–424
Wolstenholme JT, Gardner WU (1950) Sinusoidal dilatation occurring in livers of mice with a transplanted testicular tumor. Proc Soc Exp Biol Med 74:659–661
Yamada K, Ushio Y, Hayakawa T, Kato A, Yamada N (1982) Quantitative autoradiographic measurements of blood-brain barrier permeability in the rat glioma model. J Neurosurg 57:394–398
Yanoff M, Rawson AJ (1964) Peliosis hepatis. Arch Pathol 77:159–165
Zak FG (1950) Peliosis hepatis. Am J Pathol 26:1–10
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Goerdt, S., Sorg, C. Endothelial heterogeneity and the acquired immunodeficiency syndrome: a paradigm for the pathogenesis of vascular disorders. Clin Investig 70, 89–98 (1992). https://doi.org/10.1007/BF00227347
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DOI: https://doi.org/10.1007/BF00227347