Abstract
We examined single-unit activity in the inferior prefrontal cortex during a visual go/no-go discrimination task under maintained visual fixation. The monkeys had to base their response on either the color, shape, or position of a discriminative cue, and the relevant task condition was indicated by the color of the fixation spot. We analyzed the spatial selectivity of 128 go/no-go neurons showing a marked differential cue-period activity that depended on whether the stimulus signaled a go or no-go response. Most of these neurons (n = 106, 83%) showed asymmetry between their responses to stimuli in the contralateral and ipsilateral visual fields. Seventy-seven of these neurons had a contralateral preferential field, and 29 had an ipsilateral preferential field. These results show that in many inferior prefrontal neurons a degree of differentiation in their responses to go and no-go stimuli depends on the cue positions, and that the coding of behavioral meaning is carried out mainly in the contralateral hemisphere.
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References
Barbas H, Pandya DN (1989) Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey. J Comp Neurol 286:353–375
Boch RA, Goldberg ME (1989) Participation of prefrontal neurons in the preparation of visually guided eye movements in the rhesus monkey. J Neurophysiol 61:1064–1084
Boussaoud D, Desimone R, Ungerleider LG (1991) Visual topography of area TEO in the macaque. J Comp Neurol 306:554–575
Cavada C, Goldman-Rakic PS (1989) Posterior parietal cortex in rhesus monkey. II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe. J Comp Neurol 287:422–445
Funahashi S, Bruce CJ, Goldman-Rakic PS (1990) Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms. J Neurophysiol 63:814–831
Funahashi S, Bruce CJ, Goldman-Rakic PS (1993) Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic “scotomas”. J Neurosci 13:1479–1497
Goldberg ME, Bushnell MC (1981) Behavioral enhancement of visual responses in monkey cerebral cortex. II. Modulation in frontal eye fields specifically related to saccades. J Neurophysiol 46:773–787
Gross CG, Rocha-Miranda CE, Bender DB (1972) Visual properties of neurons in inferotemporal cortex of the macaque. J Neurophysiol 35:96–111
Komatsu H (1982) Prefrontal unit activity during a color discrimination task with GO and NO-GO responses in the monkey. Brain Res 244:269–277
Mikami A, Ito S, Kubota K (1982) Visual response properties of dorsolateral prefrontal neurons during visual fixation task. J Neurophysiol 47:593–605
Quintana J, Yajeya J, Fuster JM (1988) Prefrontal representation of stimulus attributes during delay tasks. I. Unit activity in cross-temporal integration of sensory and sensory-motor information. Brain Res 474:211–221
Sakagami M, Niki H (1994) Encoding of behavioral significance of visual stimuli by primate prefrontal neurons: relation to relevant task conditions. Exp Brain Res 97:423–436
Suzuki H, Azuma M (1983) Topographic studies on visual neurons in the dorsolateral prefrontal cortex of the monkey. Exp Brain Res 53:47–58
Ungerleider LG, Gaffan D, Pelak VS (1989) Projections from infero-temporal cortex to prefrontal cortex via the uncinate fascicle in rhesus monkeys. Exp Brain Res 76:473–484
Walker AE (1940) A cytoarchitectural study of the prefrontal area of the macaque monkey. J Comp Neurol 73:59–86
Watanabe M (1986) Prefrontal unit activity during delayed conditional go/no-go discrimination in the monkey. I. Relation to the stimulus. Brain Res 382:1–14
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Sakagami, M., Niki, H. Spatial selectivity of go/no-go neurons in monkey prefrontal cortex. Exp Brain Res 100, 165–169 (1994). https://doi.org/10.1007/BF00227290
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DOI: https://doi.org/10.1007/BF00227290