Abstract
In the in vitro hippocampal slice, novel interactions of a β-adrenergic agonist (l-isoproterenol) and neuropeptide (cholecystokinin 8-S) differentially produce long-lasting modifications in the dentate gyrus. When co-applied, a low concentration of l-isoproterenol (50–75 nM) and cholecystokinin 8-S (1.0 μM) produce long-lasting depression of evoked action potentials (i.e., population spikes). In contrast, the same concentration of l-isoproterenol followed by a 30-min wash with artificial cerebrospinal fluid and application of cholecystokinin 8-S produces long-lasting potentiation of evoked action potentials. In neither condition are there corresponding modifications of excitatory post-synaptic potentials. These results indicate that l-isoproterenol and cholecystokinin 8-S temporally interact to differentially produce depression or potentiation of granule cell activation. In contrast to long-lasting modifications produced by continuous application of 1.0 μM l-isoproterenol, in which both evoked action potentials and excitatory post-synaptic potentials are affected, the present novel paradigm may modify an extra-synaptic locus.
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Dahl, D., Li, J. Long-lasting potentiation and depression by novel isoproterenol and cholecystokinin 8-S interactions in the dentate gyrus. Exp Brain Res 100, 155–159 (1994). https://doi.org/10.1007/BF00227288
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DOI: https://doi.org/10.1007/BF00227288