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An autoradiographic study of satellite cell differentiation into regenerating myotubes following transplantation of muscles in young rats

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Summary

Satellite cells were traced autoradiographically during the regeneration of skeletal muscle in young Sprague-Dawley rats. Approximately 31% of the satellite cells in uninjured muscles appeared labelled after three injections of tritiated thymidine; none of the myonuclei were labelled in the same muscles. Four to six days after transplanting the radioactive muscles to non-radioactive littermates, regenerating myotube nuclei in the host appeared labelled. Thus, this study confirms that satellite cells in young rats can differentiate into multinucleated myotubes following muscle injury.

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Authors and Affiliations

  1. Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, California, USA

    Mikel H. Snow Ph.D.

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  1. Mikel H. Snow Ph.D.
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Supported by NIH grant No. 5 S01-RR05356-13

I wish to acknowledge the excellent technical assistance of Ms. Amy Erisman

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Snow, M.H. An autoradiographic study of satellite cell differentiation into regenerating myotubes following transplantation of muscles in young rats. Cell Tissue Res. 186, 535–540 (1978). https://doi.org/10.1007/BF00224941

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  • DOI: https://doi.org/10.1007/BF00224941

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