Summary
Chronic experiments were conducted on male albino rats for a histochemical study of certain oxidation-reduction enzymes (glutamic dehydrogenase, lactic dehydrogenase, glucose-6-phosphate dehydrogenase, glycerophosphate dehydrogenase, and succinic dehydrogenase) in tanycytes and arcuate nucleus nerve cells of the medial basal hypothalamus in increased hypophyseal adrenocorticotrophic function (as a result of bilateral adrenalectomy) and in suppression of that function (induced by chronic administration of dexamethasone).
Two, three, and four weeks following bilateral adrenalectomy the activity of the studied enzymes in the tanycytes was reduced. During chronic administration of 5 μg/100g dexamethasone the activity of lactic dehydrogenase, glycerophosphate dehydrogenase, and succinic dehydrogenase in the tanycytes increased. Chronic administration of 100 μg/100 g of dexamethasone was associated with a toxic effect of the drug (sharp reduction in the weight of the adrenals, retarded gain in body weight, deterioration in the animals' general condition).
After neither procedure were consistent changes found in the arcuate nucleus nerve cells.
The results obtained indicate that there is a negative correlation between tanycyte metabolism and hypophyseal adrenocorticotrophic function.
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Akmayev, I.G., Fidelina, O.V. Morphological aspects of the hypothalamic-hypophyseal system. Cell Tissue Res. 152, 403–410 (1974). https://doi.org/10.1007/BF00223957
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DOI: https://doi.org/10.1007/BF00223957