Abstract
A new approach based on nonlinear regression for the mapping of quantitative trait loci (QTLs) using complete genetic marker linkage maps is advanced in this paper. We call the approach joint mapping as it makes comprehensive use of the information from every marker locus on a chromosome. With this approach, both the detection of the existence of QTLs and the estimation of their positions, with corresponding confidence intervals, and effects can be realized simultaneously. This approach is widely applicable because only moments are used. It is simple and can save considerable computer time. It is especially useful when there are multiple QTLs and/or interactions between them on a chromosome.
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Communicated by A. L. Kahler
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Wu, W.R., Li, W.M. A new approach for mapping quantitative trait loci using complete genetic marker linkage maps. Theoret. Appl. Genetics 89, 535–539 (1994). https://doi.org/10.1007/BF00222444
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DOI: https://doi.org/10.1007/BF00222444