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The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18

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Summary

Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against a keratinocyte cell surface glycoprotein, the PV antigen (PVA). This latter protein is a member of the desmoglein subfamily of the cadherin superfamily of cell-cell adhesion molecules, present in the desmosome type of intercellular junction. The other two known desmogleins are DGI, which is a target antigen in another autoantibody-mediated blistering disease of the epidermis, pemphigus foliaceous, and HDGC, which is expressed in the basal layer of the epidermis and in the simple epithelium of, for example, the colon. Genes coding for DGI (DSG1) and HDGC (DSG2) have previously been assigned to human chromosome 18. We now present evidence, using a polymerase chain reaction assay, that DSG3, the gene coding for PVA, is assigned to the same chromosome.

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Authors and Affiliations

  1. Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, NW7 1AA, Mill Hill, London, UK

    Joachim Arnemann & Roger S. Buxton

  2. Human Genetic Resources, Imperial Cancer Research Fund, Clare Hall Laboratories, EN6 3LD, Potters Bar, Hertfordshire, UK

    Nigel K. Spurr

Authors
  1. Joachim Arnemann
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  2. Nigel K. Spurr
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  3. Roger S. Buxton
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Arnemann, J., Spurr, N.K. & Buxton, R.S. The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18. Hum Genet 89, 347–350 (1992). https://doi.org/10.1007/BF00220557

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  • DOI: https://doi.org/10.1007/BF00220557

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