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Of palindromes and peptides

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Abstract

On the average, 30% of the residues in a protein are members of peptidic palindromes, tripeptidic and longer. This percentage may go up to 50% in histones and certain other DNA binding proteins. The longest peptidic palindrome encountered thus far was 14 residues in length. However, there is every reason to expect even longer peptidic palindromes in other proteins not yet analyzed.

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References

  • Albig W, Kardalinou E, Drabent B, Mimmer A, Doenecke D (1991) Isolation and characterization of two H1 histone genes within clusters of core histone genes. Genomics 10:940–948

    Google Scholar 

  • Allard JW, Sigal IS, Dixon RAF (1987) Sequence of the gene encoding the human M1 muscarinin acetylcholine receptor. Nucleic Acids Res 15:10604

    Google Scholar 

  • Cheng G, Nandy A, Clerk S, Skoultchi AI (1989) Different 3′-end processing produces two independently regulated mRNAs from a single H1 histone gene. Proc Natl Acad Sci USA 86:7002–7006

    Google Scholar 

  • Chérif-Zahar B, Bloy C, Le Van Kim C, Blanchard D, Bailly P, Hermand P, Salmon C, Cartron J-P, Colin Y (1990) Molecular cloning and protein structure of a human blood group Rh poly-peptide. Proc Natl Acad Sci USA 87:6243–6247

    Google Scholar 

  • Cole KD, Kandala JC, Kremer E, Kistler WS (1990) Isolation of a genomic clone encoding the rat histone variant HID gene. Gene 89:265–269

    Google Scholar 

  • Dayhoff MO (1972) Atlas of protein sequence and structure, vol 5. The National Biomedical Foundation, Silver Spring, Md

    Google Scholar 

  • Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Buron ZF (1992) A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. Nature 355:464–467

    Google Scholar 

  • Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (1986) Sequence and expression of human estrogen receptor complementary DNA. Science 231:1150–1154

    CAS  PubMed  Google Scholar 

  • Nathans J, Thomas D, Hogness DS (1986) Molecular genetics of human color vision: the genes encoding glue, green, and red pigments. Science 232:193–202

    CAS  PubMed  Google Scholar 

  • Ohno S (1989) Intrinsic evolution of proteins: The role of peptidic palindromes. Rev Biol (Biology Forum) 82:341–343

    Google Scholar 

  • Ohno S (1991) To be or not to be a responder in T cell responses: ubiquitous oligopeptides in all proteins. Immunogenetics 34:215–221

    Google Scholar 

  • Ratner L, Haseltine W, Patarca R, Livak KJ, Starcich B, Josephs SF, Doran ER, Rafalski JA, Whitehorn EA, Baumeister K, Ivanoff L, Petteway SR Jr, Pearson ML, Lautenberger JA, Papas TS, Ghrayeb J, Chang NT, Gallo RC, Wong-Staal F (1985) Complete nucleotide sequence of the Aids virus, HTLV-III. Nature 313:277–284

    Google Scholar 

  • Rebbe NF, Hickman WS, Ley TJ, Stafford DW, Hickman SN (1989) Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. J Biol Chem 264:15006–15011

    Google Scholar 

  • Roqvist R, Kurnik M, Wolf-Watz H (1988) Increased virulence of Yersinia pseudotuberculosis by two independent mutations. Nature 334:522–525

    Article  CAS  PubMed  Google Scholar 

  • Tanabe T, Takeshima H, Mikami A, Flockerzi V, Takahashi H, Kanagawa K, Kojima M, Matsuo H, Hirose T, Numa S (1987) Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 328:313–318

    Google Scholar 

  • Verhoeyen M, Fang R, Jou WM, Devous R, Huylebroeck D, Saman E, Fiers W (1980) Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75. Nature 286:771–776

    Google Scholar 

  • Weeda G, Van Ham RCA, Vermeulen W, Bootsma D, Der Eb AJ, Hoeijmakers JHJ (1990) Identification of the molecular defect involving the human repair disorders xeroderma pig-mentosum and Cockayne's syndrome in the ERCC-3-encoding a presumed DNA repair helicase. Mol Cell Biol 10:2570–2581

    Google Scholar 

  • Winter G, Fields S (1981) The structure of the gene encoding the nucleoprotein of human influenza virus A/PR/8/34. Virology 114:423–428

    Google Scholar 

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This article is dedicated to Professor Ulrich Wolf in honor of his 60th birthday

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Ohno, S. Of palindromes and peptides. Hum Genet 90, 342–345 (1992). https://doi.org/10.1007/BF00220455

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  • DOI: https://doi.org/10.1007/BF00220455

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